Abstract
UNTIL recently, orthotopic transplantation of heterologous normal tissue could not be achieved in mammals. In 1956 it was demonstrated independently by Nowell et al. 1, Ford et al. 2 and Vos et al. 3 that a persistent proliferation of rat hæmatopoietic cells occurs in mice which survive a lethal total body dose of X-rays as the result of the administration of rat bone-marrow. More than one year after the transplantation in some of these mice all the erythrocytes and granulocytes were found to be of rat origin4.
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References
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Ford, L. E., Hamerton, J. L., Barnes, B. W. H., and Loutit, J. F., Nature, 177, 452 (1956).
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ZAALBERG, O., Vos, O. & VAN BEKKUM, D. Surviving Rat Skin Grafts in Mice. Nature 180, 238–239 (1957). https://doi.org/10.1038/180238b0
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DOI: https://doi.org/10.1038/180238b0
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