Abstract
WITH the demonstration1 that the main internucleotidic linkage in ribonucleic acids is b : 5′, it is clear that a final decision between 2′ : 5′ and 3′ : 5′ as possible linkage positions2 can be reached by determining the location of the phosphoryl group in the isomeric a and b nucleotides obtained by alkaline hydrolysis of ribonucleic acids3. Brown and Todd4 showed that these nucleotides are the 2′- and 3′-phosphates of the corresponding nucleosides, although not necessarily respectively.
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References
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Brown, D. M., Dekker, C. A., and Todd, A. R., J. Chem. Soc., 2715 (1952).
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Corby, N. S., Kenner, G. W., and Todd, A. R., J. Chem. Soc., 3669 (1952).
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BROWN, D., FASMAN, G., MAGRATH, D. et al. Structure of Adenylic Acids a and b . Nature 172, 1184–1185 (1953). https://doi.org/10.1038/1721184a0
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DOI: https://doi.org/10.1038/1721184a0
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