Abstract
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient in ET-1. These ET-1-/- homozygous mice die of respiratory failure at birth and have morphological abnormalities of the pharyngeal-arch-derived craniofacial tissues and organs. ET-1+/- heterozygous mice, which produce lower levels of ET-1 than wild-type mice, develop elevated blood pressure. These results suggest that ET-1 is essential for normal mouse development and may also play a physiological role in cardiovascular homeostasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Yanagisawa, M. et al. Nature 332, 411–415 (1988).
Inoue, A. et al. Proc. natn. Acad. Sci. U.S.A. 86, 2863–2867 (1989).
Komuro, I. et al. FEBS Lett. 238, 249–252 (1988).
De Nucci, G. D. R. et al. Proc. natn. Acad. Sci. U.S.A. 85, 9797–9800 (1988).
Fukuda, Y. et al. Biochem. biophys. Res. Commun. 155, 167–172 (1988).
Morishita, R., Higaki, J. & Ogihara, T. Biochem. biophys. Res. Commun. 160, 628–632 (1989).
Rakugi, H. et al. Biochem. biophys. Res. Commun. 155, 1244–1247 (1988).
Yanagisawa, M. & Masaki, T. Trends pharmac. Sci. 10, 374–378 (1989).
Mansour, S. L., Thomas, K. R. & Capecchi, M. R. Nature 336, 348–352 (1988).
Bloch, K. D. et al. J. biol. Chem. 264, 10851–10857 (1989).
Inoue, A. et al. J. biol. Chem. 264, 14954–14959 (1989).
Azuma, S. & Toyoda, Y. Jap. J. anim. Reprod. 37, 37–43 (1991).
Giaid, A. et al. Proc. natn. Acad. Sci. U.S.A. 86, 7634–7638 (1989).
Koseki, C., Imai, M., Hirata, Y., Yanagisawa, M. & Masaki, T. Neurosci. Res. 6, 581–585 (1989).
Spyer, K. M. et al. J. cardiovasc. Pharmac. 17, S385–S389 (1991).
Kuwaki, T., Cao, W.-H., Unekawa, M., Terui, M. & Kumada, M. J. Auton. Nerv. Syst. 36, 149–158 (1991).
Kuwaki, T., Koshiya, N., Terui, M. & Kumada, M. Neurochem. Int. 18, 519–524 (1991).
Kuwaki, T., Cao, W.-H., Yamamoto, M., Terui, N. & Kumada, M. J. cardiovasc. Pharmac. 17, S343–S345 (1991).
Noden, D. M. Brain behav. Evol. 38, 190–225 (1991).
Lumsden, A. G. S. Development 103S, 155–169 (1988).
Johnston, M. C. & Bronsky, P. T. J. Craniofac. Genet. dev. Biol. 11, 277–291 (1991).
Gurdon, J. B. Cell 68, 185–199 (1992).
Vainio, S., Karavanova, I., Jowett, A. & Thesleff, I. Cell 75, 45–58 (1993).
Chisaka, O. & Capecchi, M. R. Nature 350, 473–479 (1991).
Lufkin, T., Dieruch, A., LeMeur, M., Mark, M. & Chambon, P. Cell 66, 1105–1119 (1991).
Chisaka, O., Musci, T. S. & Capecchi, M. R. Nature 355, 516–520 (1992).
Lammer, E. J. et al. New Engl. J. Med. 313, 837–841 (1985).
Kay, E. D. Teratology 35, 105–117 (1987).
Acampora, D. et al. Nucleic Acids Res. 17, 10385–10402 (1989).
McKenzie, J. Arch. Dis. Childh. 33, 477–486 (1958).
Noden, D. M. J. Craniofac. Genet. dev. Biol. 2 (Suppl.), 15–31 (1986).
Yasujima, M. et al. Am. J. Hypertens. 3, 635–637 (1990).
Mortensen, L. H., Pawloski, C. M., Kanagy, N. L. & Fink, G. D. Hypertension 15, 729–733 (1990).
Yokokawa, K. et al. Ann. Intern. Med. 114, 213–215 (1991).
Luesher, T. F., Boulanger, C. M., Dohi, Y. & Yang, Z. Hypertension 19, 117–130 (1992).
Takagi, Y. et al. Am. J. Hypertens. 4, 389–391 (1991).
Kuwaki, T. et al. Jap. J. Physiol. 40, 827–841 (1990).
Ouchi, Y. et al. Am. J. Physiol. 256, H1747–H1751 (1989).
Kumada, M., Terui, N. & Kuwaki, T. Progr. Neurobiol. 35, 331–361 (1990).
Cao, W.-H. et al. J. cardiovasc. Pharmac. 22 (suppl. 8), 5196–5198 (1993).
Mosqueda-Garcia, R., Inagami, T., Appalsamy, M., Sugiura, M. & Robertson, R. M. Circ. Res. 72, 20–35 (1992).
Saida, K., Mitsui, Y. & Ishida, N. J. biol. Chem. 264, 14613–14616 (1989).
Sukuki, N., Matsumoto, H., Kitada, C., Masaki, T. & Fujino, M. J. immun. Meth. 118, 245–250 (1989).
Matsumoto, H., Suzuki, N., Onda, H. & Fujino, M. Biochem. biophys. Res. Commun. 164, 74–80 (1989).
McLoad, M. J. Teratology 22, 299–301 (1980).
Kromillar, J. E., Upholt, W. B. & Kollar, E. J. Devl Biol. 147, 485–488 (1991).
Wilkinson, D. in In Situ Hybridisation: a Practical Approach (ed. Wilkinson, D.) 75–84 (IRL, Oxford, 1992).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kurihara, Y., Kurihara, H., Suzuki, H. et al. Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1. Nature 368, 703–710 (1994). https://doi.org/10.1038/368703a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/368703a0
This article is cited by
-
Sleep Apnea and Hypertension
High Blood Pressure & Cardiovascular Prevention (2022)
-
Relationship between endothelin and nitric oxide pathways in the onset and maintenance of hypertension in children and adolescents
Pediatric Nephrology (2022)
-
Endothelial ERG alleviates cardiac fibrosis via blocking endothelin-1-dependent paracrine mechanism
Cell Biology and Toxicology (2021)
-
Production of genetically engineered mice with higher efficiency, lower mosaicism, and multiplexing capability using maternally expressed Cas9
Scientific Reports (2020)
-
Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke
Journal of Neuroinflammation (2019)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.