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The potential use of raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers

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Abstract

Scanning near-infrared Raman microscopy has been used to map aerosol particulate deposits produced from pressurized metered-dose inhalers (pMDI). A commercially available combination asthma therapy pMDI (Ventide, Allen and Hanbury, UK), containing salbutamol and beclometasone dipropionate, was analyzed by conventional in vitro quantitative analysis and scanning Raman microscopy. Raman maps, taken from Andersen cascade impactor plate stages 3 and 5 (over 100 × 100 μm areas) suggested good correlation with chemical analysis of the respective stages. Scanning Raman microscopy allows visual differentiation between formulation components (not possible using conventional imaging techniques), while potentially allowing chemical quantification.

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Authors and Affiliations

  1. Pharmaceutical Technology Research Group, Department of Pharmacy and Pharmacology, University of Bath, BA2 7AY, Bath, UK

    D. Fraser Steele, Paul M. Young, Robert Price, Stephen Edge & David Lewis

  2. Spectroscopy products Division, Renishaw plc, GL12 7DW, Old Town, Wotton-under-Edge, Gloucestershire, UK

    Timothy Smith

Authors
  1. D. Fraser Steele
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  2. Paul M. Young
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  3. Robert Price
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  4. Timothy Smith
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  5. Stephen Edge
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  6. David Lewis
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Corresponding author

Correspondence to Paul M. Young.

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Published: October 29, 2004.

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Steele, D.F., Young, P.M., Price, R. et al. The potential use of raman mapping to investigate in vitro deposition of combination pressurized metered-dose inhalers. AAPS J 6, 32 (2004). https://doi.org/10.1208/aapsj060432

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  • DOI: https://doi.org/10.1208/aapsj060432

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