A missing link in glycolysis

Latest research

1. 1. Medicine
   2. Stem Cells and Regenerative Medicine

   Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

   Daniel Chen, Polyxeni Philippidou ... Helen C. Miranda
2. 1. Microbiology and Infectious Disease

   Mycobacterium tuberculosis PhoP integrates stress response to intracellular survival by regulating cAMP level

   Hina Khan, Partha Paul ... Dibyendu Sarkar
3. 1. Cell Biology
   2. Physics of Living Systems

   Partitioning to ordered membrane domains regulates the kinetics of secretory traffic

   Ivan Castello-Serrano, Fred A. Heberle ... Ilya Levental
4. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Context-Aware Amino Acid Embedding Advances Analysis of TCR-Epitope Interactions

   Pengfei Zhang, Seojin Bang ... Heewook Lee
5. 1. Cell Biology
   2. Plant Biology

   ATG6 interacting with NPR1 increases Arabidopsis thaliana resistance to Pst DC3000/avrRps4 by increasing its nuclear accumulation and stability

   Baihong Zhang, Shuqin Huang ... Wenli Chen
6. 1. Neuroscience

   CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction

   Natalia F. Mendes, Ariane M. Zanesco ... Licio A. Velloso
7. 1. Microbiology and Infectious Disease

   Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection

   Kavidha Reddy, Guinevere Q. Lee ... Thumbi Ndung’u
8. 1. Cancer Biology
   2. Cell Biology

   Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

   Timothy J Walker, Eduardo Reyes-Alvarez ... Lois M Mulligan

   TMEM127 depletion alters membrane dynamics, promoting cell surface accumulation and constitutive activity of growth factor receptors, and ultimately providing a novel paradigm for oncogenesis through aberrant receptor localization and signaling.
9. 1. Evolutionary Biology

   Synthetic analysis of trophic diversity and evolution in Enantiornithes with new insights from Bohaiornithidae

   Case Vincent Miller, Jen A Bright ... Michael Pittman

   Enantiornithine birds reached similar dietary diversity to modern birds in a similar amount of time many millions of years earlier, but how exactly they did that requires further research.
10. 1. Neuroscience

    Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs

    Yu-Feng Xie, Jane Yang ... Steven A Prescott

    Because nociceptors can achieve similar excitability using different sodium channel subtypes, it is difficult to know which channels are being used yet this information is critical for predicting if subtype-selective drugs will reduce pain.