Maintaining sufficient levels of plant nutrients in the soil and controlling certain heavy metals, which can be toxic to the environment, are critical to ensure sustainable agricultural production. The study aimed to assess the linkage of crop-specific agricultural practices established by farmers in the Kvemo Kartli region (Georgia) with metal accumulation in soils of agricultural lands being subject to influence from polluted irrigation water in the past. In particular, we tried to identify the primary sources of micro-nutrients, including iron (Fe), copper (Cu), manganese (Mn), nickel (Ni), and zinc (Zn), and toxic elements such as cadmium (Cd) and lead (Pb), and the share of the contaminated irrigation water and other factors related to agricultural practices under different land uses, such as intensive and extensive arable farming, vineyards, orchards, and permanent pastures having the least disturbed soil. Based on principal component analysis, five primary sources were identified and categorized according to farmer interviews and previous studies conducted in the region. The results showed that increased concentrations of plant-available Cu, Zn, Cd, and Pb were mainly associated with irrigation water and intensive use of fungicides; Fe, Mn, and Ni were closely linked to several factors, such as the mineralogical composition of soils, minerals, and organic fertilizers inputs; and atmospheric deposition from diffuse sources, where exhausts from transport are probably the primary source. During our study, we attempted to differentiate irrigation water inputs from fungicides using simulation based on irrigation patterns and irrigation water quality on the one hand and fungicide application rates and their metal contents on the other. The simulation revealed that the intensive application of fungicides, especially in vineyards, is more significant in enriching soils with Cu and Zn than irrigation water. Identification of factorial dependences was supported by statistical analysis and application of several contamination assessment methods: contamination factor (CF), pollution load index (PLI), single-factor pollution index (PI), Nemerow’s comprehensive pollution index (PIN), enrichment factor (EF), and geo-accumulation index (Igeo). Applied environmental indices indicate that the soils under the former and existing vineyards are the most enriched with Cu and Zn, highlighting the significance of agricultural practices on heavy metal accumulations in the soils of agricultural lands. Full article

A thermodynamic constitutive damage model for plain concrete, and other quasi-brittle aging materials, under creep relaxation is developed. The model accounts for the anisotropic damage induced through a second-order tensor damage variable. The aging viscoelasticity of the material is considered through the theory of solidification for aging solidifying materials. The material is considered a viscoelastic-damageable material. The Helmholtz free energy, utilized in the formulation, is treated based on the representation theorem of coupled damage strain tensors and Volterra integral equations. The model can analyze time-dependent damage (tertiary creep) under constant loading and can account for damage due to cyclic creep. Theoretical case studies are considered to illustrate the applicability of the model. The determination of the functions and constants, representing the material behavior, as well as any experimental companion is proposed for further research. Full article

Background: Implanted titanium skull plates (TSPs) in cranioplasty are used to replace or reconstruct areas of the skull that have been damaged or removed due to trauma, surgery, or other medical conditions. However, the presence of a TSP in the head may influence the distribution of the electric field induced during transcranial magnetic stimulation (TMS) procedures. The purpose of this study was to determine how the presence of TSP would interfere with TMS-induced cortical electric fields. Methods: The TMS with a figure-of-eight coil was applied to a realistic head model with TSPs. The distribution of the induced electric field in head tissues was calculated by employing the impedance method, and the results were compared with that of a normal head without TSP. Results: Simulation results show that the distribution of the induced electric field has changed greatly for the head model with TSP. The maximum value of the induced electric field in head tissues was present under one of the circular coil wings rather than in the tissues beneath the junction of the two wings of the Fo8 coil. Conclusions: The induced electric field in deep brain regions was increased for the head model with TSP, which could potentially lead to deep brain stimulation. Since the presence of metallic TSP can greatly influence the distribution of the induced electric field in TMS applications, it is important to adjust the treatment scheme when considering TMS for individuals with cranial titanium plates. Full article

Background and Objectives: Worldwide, preterm birth (PTB) stands as the primary cause of mortality among children under 5 years old. Socioeconomic factors significantly impact pregnancy outcomes, influencing both maternal well-being and newborn health. Understanding and addressing these socioeconomic factors is essential for developing effective public health interventions and policies aimed at improving pregnancy outcomes. This study aims to analyse the relationship between socioeconomic factors (education level, marital status, place of residence and nationality) and PTB in Latvia, considering mother’s health habits, health status, and pregnancy process. Materials and Methods: A cross-sectional study was conducted using data from the Medical Birth Register (MBR) of Latvia about women with singleton pregnancies in 2022 (n = 15,431). Data analysis, involving crosstabs, chi-square tests, and multivariable binary logistic regression, was performed. Adjusted Odds ratios (aOR) with 95% confidence intervals (CI) were estimated. Results: Lower maternal education was statistically significantly associated with increased odds of PTB. Mothers with education levels below secondary education had over two times higher odds of PTB (aOR = 2.07, p < 0.001, CI 1.58–2.70) and those with secondary or vocational secondary education had one and a half times higher odds (aOR = 1.58, p < 0.001, CI 1.33–1.87) after adjusting for other risk factors. Study results also showed the cumulative effect of socioeconomic risk factors on PTB. Additionally, mothers facing two or three socioeconomic risk factors in Latvia exhibited one and a half times higher odds of PTB (aOR = 1.59, p = 0.021). Conclusions: The study highlights the cumulative impact of socioeconomic risk factors on PTB, with higher maternal education demonstrating the highest protective effect against it. This underscores the importance of education in promoting optimal foetal development. Since the influence of socioeconomic factors on PTB is not a widely studied issue in Latvia, further research is needed to improve understanding of this complex topic. Full article

A very important class of models widely used nowadays to describe and predict, at least in stochastic terms, the behavior of many-particle systems (where the word “particle” is not meant in the purely mechanical sense: particles can be cells of a living tissue, or cars in a traffic flow, or even members of an animal or human population) is the Kinetic Theory for Active Particles, i.e., a scheme of possible generalizations and re-interpretations of the Boltzmann equation. Now, though in the literature on the subject this point is systematically disregarded, this scheme is based on Markov Chains, which are special stochastic processes with important properties they share with many natural processes. This circumstance is here carefully discussed not only to suggest the different ways in which Markov Chains can intervene in equations describing the stochastic behavior of any many-particle system, but also, as a preliminary methodological step, to point out the way in which the notion of a Markov Chain can be suitably generalized to this aim. As a final result of the discussion, we find how to develop new very plausible and likely ways to take into account possible effects of the external world on a non-isolated many-particle system, with particular attention paid to socio-economic problems. Full article

We develop a framework for creating distortion functions that are used to construct new bivariate copulas. It is achieved by transforming non-negative random variables with Lomax-related distributions. In this paper, we apply the distortions to the base copulas of independence, Clayton, Frank, and Gumbel copulas. The properties of the tail dependence coefficient, tail order, and concordance ordering are explored for the new families of distorted copulas. We conducted an empirical study using the daily net returns of Amazon and Google stocks from January 2014 to December 2023. We compared the popular Clayton, Gumbel, Frank, and Gaussian copula models to their corresponding distorted copula models induced by the unit-Lomax and unit-inverse Pareto distortions. The new families of distortion copulas are equipped with additional parameters inherent in the distortion function, providing more flexibility, and are demonstrated to perform better than the base copulas. After analyzing the data, we have found that the joint extremes of Amazon and Google stocks are more likely for high daily net returns than for low daily net returns. Full article

Microalgae have considerable potential as a renewable feedstock for biochemical and bioethanol production that can be employed in processes associated with carbon capture. Large-scale microalgae cultivations are often non-axenic and are often cohabited by bacteria. A better understanding of the influence of cohabiting bacteria on microalgae productivity is required to develop sustainable synthetic co-culture processes at scale. Nutrient limitation is a frequently employed strategy in algal cultivations to accumulate energy reserves, such as lipids and carbohydrates. Here, a non-axenic culture of an estuarine green microalga, Chlorella vulgaris CCAP 211/21A, was studied under nutrient replete and deplete conditions to assess how changes in nutrient supply influenced the cohabiting bacterial population and its association with intracellular carbohydrate accumulations in the alga. Nutrient limitation resulted in a maximum carbohydrate yield of 47%, which was 74% higher than that in nutrient replete conditions. However, the latter condition elicited a 2-fold higher carbohydrate productivity. Three cohabiting bacterial isolates were cultivable from the three culture conditions tested. These isolates were identified using the 16S rRNA gene sequence to belong to Halomonas sp. and Muricauda sp. The composition of the bacterial population varied significantly between the growth conditions and time points. In all cases and at all time points, the dominant species was Halomonas isolates. Nutrient depletion resulted in an apparent loss of Muricauda sp. This finding demonstrates that nutrient supply can be used to control cohabiting bacterial populations in algal cultures, which will enable the development of synthetic co-culture strategies for improving algae productivity. Full article

Cold plasma (CP) is an ionised gas containing excited molecules and ions, radicals, and free electrons, and which emits electric fields and UV radiation. CP is potently antimicrobial, and can be applied safely to biological tissue, birthing the field of plasma medicine. Reactive oxygen and nitrogen species (RONS) produced by CP affect biological processes directly or indirectly via the modification of cellular lipids, proteins, DNA, and intracellular signalling pathways. CP can be applied at lower levels for oxidative eustress to activate cell proliferation, motility, migration, and antioxidant production in normal cells, mainly potentiated by the unfolded protein response, the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)-activated antioxidant response element, and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway, which also activates nuclear factor-kappa B (NFκB). At higher CP exposures, inactivation, apoptosis, and autophagy of malignant cells can occur via the degradation of the PI3K/Akt and mitogen-activated protein kinase (MAPK)-dependent and -independent activation of the master tumour suppressor p53, leading to caspase-mediated cell death. These opposing responses validate a hormesis approach to plasma medicine. Clinical applications of CP are becoming increasingly realised in wound healing, while clinical effectiveness in tumours is currently coming to light. This review will outline advances in plasma medicine and compare the main redox and intracellular signalling responses to CP in wound healing and cancer. Full article

Alcoholism presents a significant health concern with notable socioeconomic implications. Alcohol withdrawal syndrome (AWS) can manifest when individuals cease or drastically reduce their alcohol consumption after prolonged use. Non-alcoholic fatty liver disease (NAFLD) is characterized by substantial lipid accumulation in the liver cells of individuals with no history of alcohol consumption. There is evidence suggesting an association between cognitive impairment and both conditions. This study aimed to evaluate cognitive impairment in patients with NAFLD and AWS using the Mini-Mental State Examination (MMSE). This study involved 120 patients admitted to two hospitals in Craiova, Romania. Results indicated that patients with NAFLD did not exhibit cognitive impairment as measured by MMSE (Mean = 29.27, SD = 0.785). Conversely, patients with AWS showed more pronounced cognitive dysfunction, with a mean MMSE score at admission of 16.60 ± 4.097 and 24.60 ± 2.832 after 2 weeks under treatment with Vitamins B1 and B6 and Cerebrolysin. Additionally, our findings suggested that cognitive dysfunction among alcohol consumers was correlated with the severity of clinical symptoms, as demonstrated by the severity of tremors in our study. The two-week period under treatment and alcohol withdrawal was insufficient for cognitive function to return to normal levels. Observational studies on longer periods of time are advised. Full article

As artificial intelligence (AI) integrates within the intersecting domains of healthcare and computational biology, developing interpretable models tailored to medical contexts is met with significant challenges. Explainable AI (XAI) is vital for fostering trust and enabling effective use of AI in healthcare, particularly in image-based specialties such as pathology and radiology where adjunctive AI solutions for diagnostic image analysis are increasingly utilized. Overcoming these challenges necessitates interdisciplinary collaboration, essential for advancing XAI to enhance patient care. This commentary underscores the critical role of interdisciplinary conferences in promoting the necessary cross-disciplinary exchange for XAI innovation. A literature review was conducted to identify key challenges, best practices, and case studies related to interdisciplinary collaboration for XAI in healthcare. The distinctive contributions of specialized conferences in fostering dialogue, driving innovation, and influencing research directions were scrutinized. Best practices and recommendations for fostering collaboration, organizing conferences, and achieving targeted XAI solutions were adapted from the literature. By enabling crucial collaborative junctures that drive XAI progress, interdisciplinary conferences integrate diverse insights to produce new ideas, identify knowledge gaps, crystallize solutions, and spur long-term partnerships that generate high-impact research. Thoughtful structuring of these events, such as including sessions focused on theoretical foundations, real-world applications, and standardized evaluation, along with ample networking opportunities, is key to directing varied expertise toward overcoming core challenges. Successful collaborations depend on building mutual understanding and respect, clear communication, defined roles, and a shared commitment to the ethical development of robust, interpretable models. Specialized conferences are essential to shape the future of explainable AI and computational biology, contributing to improved patient outcomes and healthcare innovations. Recognizing the catalytic power of this collaborative model is key to accelerating the innovation and implementation of interpretable AI in medicine. Full article

This exploratory and analytical research examines secondary sources to propose a résumé of professional roles for journalists to revitalize their roles within social and political coexistence. It aims to bridge the gap between theoretical concepts and practical applications, enhancing journalists’ impact on public discourse and informed decision-making. Empirical research will guide these roles’ implementation in real-world journalistic practices. Twelve explanatory and constructive journalistic roles are formulated, whose relevance and application are enhanced in societies undergoing crisis situations or serious difficulties and are at risk of rupture in coexistence. In conclusion, the role of journalists in the current circumstances of crises in democratic societies requires them to not only report on events but also provide context, analysis, and solutions to the complex issues faced by society. Journalistic functions such as contextualization, public interest promotion, dialogue, and motivation are considered fundamental beyond constructive journalism or solutions journalism. Full article

Heart failure with preserved ejection fraction (HFpEF) is a major health concern. There is a growing recognition of the causal interplay between arterial stiffness and HFpEF. We recently reported that phosphate retention is a trigger for arterial stiffness. This study focuses on whether arterial stiffness due to phosphate retention could be a predictor for HFpEF. Methods: The subjects of this study were 158 patients (68 males and 90 females, mean age 74.8 ± 11.2). HFpEF was defined according to the guidelines of the ESC 2019. Pulse wave velocity (PWV) and central systolic blood pressure (CSBP) were used as markers for arterial stiffness and afterload, respectively. We measured serum levels of fibroblast growth factor 23 (FGF23) as a marker of phosphate retention. Results: The serum levels of FGF23 had a significant relationship with PWV. PWV had significant relationships with LV mass index, plasma BNP levels, and relative wall thickness, e’, and E/e’ (p < 0.001, respectively). Multivariate logistic regression analysis revealed that higher PWV values and hypertension were significant predictors for the dependent factor (HFpEF). Arterial stiffness amplified afterload, leading to LV concentric hypertrophy and diastolic dysfunction. This study presents that arterial stiffness is a key predictor of HFpEF, and that phosphate retention is involved in the pathology of HFpEF. Full article

Battery cell finalization is a crucial process chain in battery manufacturing, contributing to a significant share of CAPEX and OPEX. Thus, there is a high cost-saving potential by improving the process chain. This research paper investigates various crucial facets of the cell finalization process in battery cell production through an expert survey. These include investment cost allocation, potential cost savings in sub-processes, reject generation, early detection of faulty cells, quality measurement techniques, and the utilization of inline data for early quality determination and real-time process control during the formation process. A solution approach for the implementation of electrochemical impedance spectroscopy for inline early quality determination is given. The results yield valuable insights for optimizing the formation process and enhancing product quality. Full article

In this research, an innovative electric vehicle (EV) charger is designed and presented for xEV charging stations. The key feature of our system is a scalable, interleaved inductor–inductor–capacitor (iL²C) DC-DC converter operation. The proposed system employs two parallel L²C converters with 8-GaN switches on the primary side and a shared rectifier circuit on the secondary side. This configuration not only amplifies the resonant tank internal currents and losses generated by the switches but also improves current sharing. A novel closed-loop technique is proposed with a constant-voltage method of operation, along with a hybrid control scheme of variable frequency + phase shift modulation (VFPSM). To examine the controller and converter’s performance, an experimental demonstration is conducted under varying load conditions, including full load, half load, and light load, where the source voltage and load voltage are maintained at constant levels of 400 V_in and 48 V₀, respectively. Furthermore, line regulation is conducted and verified to accommodate a broad input voltage range of 300 V_in–500 V_in and 500 V_in–300 V_in while maintaining an output voltage of 48 V₀ at 3.3 kW, 1.65 kW, and 0.33 kW with a peak efficiency of 98.2%. Full article

Background and Objectives: This randomized, double-arm, multicentric clinical trial aims to compare the clinical outcomes following the treatment of suprabony periodontal defects using open flap debridement (OFD) with or without the application of hyaluronic acid (HA). Materials and Methods: Sixty systemically healthy patients with at least two teeth presenting suprabony periodontal defects were randomly assigned with a 1:1 allocation ratio using computer-generated tables into a test (OFD + HA) or control group (OFD). The main outcome variable was clinical attachment level (CAL). The secondary outcome variables were changes in mean probing pocket depth (PPD), gingival recession (GR), full-mouth plaque score (FMPS), and full-mouth bleeding score (FMBS). All clinical measurements were carried out at baseline and 12 months. Results: Sixty patients, thirty in each group, were available for statistical analysis. The mean CAL gain was statistically significantly different (p < 0.001) in the test group compared with the control group (3.06 ± 1.13 mm vs. 1.44 ± 1.07 mm). PPD reduction of test group measurements (3.28 ± 1.14 mm) versus the control group measurements (2.61 ± 1.22 mm) were statistically significant (p = 0.032). GR changes were statistically significant only in the test group 0.74 ± 1.03 mm (p < 0.001). FMBS and FMPS revealed a statistically significant improvement mostly in the test group. Conclusions: Suprabony periodontal defects could benefit from the additional application of HA in conjunction with OFD in terms of improvement of the clinical parameters compared with OFD alone. Full article

Radiocesium (r-Cs) and radiostrontium (r-Sr) released from nuclear accidents (e.g., Chornobyl, Fukushima) and routine operations (reactors, reprocessing) pose environmental and health concerns. Their primary pathway to humans is through plant uptake and subsequent bioaccumulation within the food chain. While soil amendments with potassium (K) and calcium (Ca) are known to mitigate r-Cs and r-Sr uptake, respectively, the impact on plant growth remains unclear. This study investigates the effects of Cs and Sr on the growth of Holcus lanatus L. seedlings under hydroponic and soil conditions with varying Cs and Sr concentrations. Stable isotopes of Cs and Sr served as non-radioactive analogs. Seedling growth was assessed across a range of Cs and Sr concentrations (≤1 and ≥4 mg L⁻¹). The impact of the addition of K and Ca on Cs/Sr uptake in amended soils was also evaluated. Additionally, this study examined how Cs and Sr amendments affected the influx rates of other nutrients in H. lanatus. Higher Cs and Sr concentrations (≥4 mg L⁻¹) significantly inhibited seedling growth, while lower concentrations had no effect. Notably, H. lanatus exhibited moderate Cs tolerance and strong Sr tolerance. Furthermore, K and Ca supplementation in Cs/Sr-amended soils demonstrably reduced plant uptake of these elements. This study also observed alterations in the uptake rates of other nutrients within H. lanatus due to Cs/Sr addition. This study suggests that H. lanatus exhibits moderate tolerance to Cs and Sr contamination, potentially making it suitable for revegetation efforts in contaminated grasslands. Additionally, K and Ca amendments show promise as a strategy to mitigate plant uptake of these radioisotopes further. These findings contribute to the development of safer revitalization strategies for areas impacted by nuclear accidents. Full article

Background and Objectives: Cardiac autonomic neuropathy (CAN) is a severe complication of diabetes mellitus (DM) strongly linked to a nearly five-fold higher risk of cardiovascular mortality. Patients with Type 2 Diabetes Mellitus (T2DM) are a significant cohort in which these assessments have particular relevance to the increased cardiovascular risk inherent in the condition. Materials and Methods: This study aimed to explore the subtle correlation between the Ewing test, Sudoscan-cardiovascular autonomic neuropathy score, and cardiovascular risk calculated using SCORE 2 Diabetes in individuals with T2DM. The methodology involved detailed assessments including Sudoscan tests to evaluate sudomotor function and various cardiovascular reflex tests (CART). The cohort consisted of 211 patients diagnosed with T2DM with overweight or obesity without established ASCVD, aged between 40 to 69 years. Results: The prevalence of CAN in our group was 67.2%. In the study group, according SCORE2-Diabetes, four patients (1.9%) were classified with moderate cardiovascular risk, thirty-five (16.6%) with high risk, and one hundred seventy-two (81.5%) with very high cardiovascular risk. Conclusions: On multiple linear regression, the SCORE2-Diabetes algorithm remained significantly associated with Sudoscan CAN-score and Sudoscan Nephro-score and Ewing test score. Testing for the diagnosis of CAN in very high-risk patients should be performed because approximately 70% of them associate CAN. Increased cardiovascular risk is associated with sudomotor damage and that Sudoscan is an effective and non-invasive measure of identifying such risk. Full article

The field of archaeological excavation has seen enormous developments as a result of the quick development of digital technologies. It is critical to acknowledge the long-term benefits of new approaches. In this regard, this study intends to suggest a system that provides archaeologists with digital tools that allow them to fully and effectively document their excavations in real time while in the field, which is specifically designed for classical and Byzantine archaeology. The system not only facilitates traditional documentation practices but also integrates advanced geospatial technologies and augmented reality, enhancing the accuracy and depth of archaeological research and preservation. This dual functionality enables both the efficient recording of excavation data as experienced by excavators on-site and the detailed documentation processed by researchers post-excavation. The objective of the application is to generate a sophisticated system that will enable the excavation data and experience that the excavator gains on the site of work to be recorded in real time, as well as the documentation that is subsequently processed and accomplished by the researcher or by other researchers. The system saves detailed images and 3D models of artifacts and excavation sites. This ensures that every detail is recorded while preserving the data for future analysis and reference. Lastly, the application was tested in realistic use case scenarios and real-world settings, which increased the system’s credibility and demonstrated its capability to enhance the procedures involved in archaeological excavation and documentation. Full article

Background and Objectives: Before COVID-19 vaccinations became available, adhering to non-pharmaceutical interventions (NPIs), like social distancing (SD), wearing masks, and hand hygiene, were crucial to mitigating viral spread. Many studies reported that younger individuals were more reluctant to follow these measures compared with older ones. We hypothesized that it would be worthwhile to find factors that influenced SD compliance among young people during the pre-vaccination phase of a pandemic. Materials and Methods: We analyzed data of adults aged 19–44 from the 2020 South Korean Community Health Survey and compared socio-demographic, health-related behavioral, and psychological factors between compliant and non-compliant cohorts. Results: A total of 59,943 participants were enrolled and we found that older age groups (30–39 and 40–44) and safety concerns (such as viral infection, virus-related death, economic damage, and transmitting virus to vulnerable people) were significantly associated with adherence to SD. Conversely, participants who were not living with a spouse, were unable to stay at home despite symptoms, smoked, drank, and had a negative attitude toward government policy statistically correlated with non-compliance. Conclusions: In times when NPIs were the primary defense against the pandemic, it is essential to identify factors that positively or negatively affect individual compliance with them, especially among young people. Using a large-scale, well-designed national survey, we could gain insights into the early recognition of risk factors for non-compliance and appropriate follow-up interventions (i.e., education campaigns, clear communication of public guidelines, and implementation of guidelines), which will help people to avoid suffering from other waves of future infectious diseases. Full article

We introduce a modeling framework aimed at incorporating symbolic discrete controller synthesis (DCS) into a virtual robot experimental platform. This framework involves symbolically representing the behaviors of robotic systems along with their control objectives using synchronous programming techniques. We employed DCS algorithms through the reactive synchronous environment ReaX to generate controllers that fulfill specified objectives. These resulting controllers were subsequently deployed on the virtual robot experimental platform Simscape. To demonstrate and validate our approach, we provide an implementation example involving collaborative UAV robots. Full article

The multi-scale study of rock properties is a necessary step in the planning of oil and gas reservoir developments. The amount of core samples available for research is usually limited, and some of the samples can be distracted. The investigation of core reconstruction possibilities is an important task. An approach to the real-size reconstruction of porous media with a given (target) porosity and permeability by controlling the parameters of FFF 3D printing using CT images of the original core is proposed. Real-size synthetic core specimens based on CT images were manufactured using FFF 3D printing. The possibility of reconstructing the reservoir properties of a sandstone core sample was proven. The results of gas porometry measurements showed that the porosity of specimens No.32 and No.46 was 13.5% and 12.8%, and the permeability was 442.3 mD and 337.8 mD, respectively. The porosity of the original core was 14% and permeability was 271 mD. It was found that changing the layer height and nozzle diameter, as well as the retract and restart distances, has a direct effect on the porosity and permeability of synthetic specimens. This study shows that porosity and permeability of synthetic specimens depend on the flow of the material and the percentage of overlap between the infill and the outer wall. Full article

Pancreatic pseudocysts often arise as complications of pancreatitis and present unique challenges in clinical management, encompassing considerations for both technical aspects and financial implications. Before the advancements of invasive gastroenterology, pancreatic pseudocysts have been drained surgically for many years. Nowadays, we have less invasive techniques with higher efficiency and lower mortality rates, however, they remain cost-challenging for most countries. Materials and Methods: We present four patients (two males and two females) with pancreatic pseudocysts who underwent endoscopic ultrasound-guided transgastric drainage using plastic stents accompanied by a standard lavage protocol using a nasocystic catheter. Results: All four patients had successful outcomes, and a follow-up at 6 months revealed no traces of the pseudocysts or any significant long-term complications. One acute complication (arterial bleeding) and one late complication (stent migration) were observed. As the study aimed to present a cheaper option for draining pancreatic pseudocysts, we investigated and compared costs for the materials we utilized and those associated with lumen-apposing metal stents. Upon compiling the data, a notable advantage was evident in favour of our method. Conclusions: While EUS-guided drainage of pancreatic pseudocysts using lumen-apposing metal stents (LAMSs) represents a high-end strategy for treating pancreatic pseudocysts, our method demonstrates better cost-effectiveness without compromising efficacy. Full article