• Open Access

Multimodal Phase-Based X-Ray Microtomography with Nonmicrofocal Laboratory Sources

Fabio A. Vittoria, Marco Endrizzi, Gibril K. Kallon, Charlotte K. Hagen, Francesco Iacoviello, Paolo De Coppi, and Alessandro Olivo
Phys. Rev. Applied 8, 064009 – Published 8 December 2017

Abstract

We present an alternative laboratory implementation of x-ray phase-contrast tomography through a beam-tracking approach. A nonmicrofocal rotating anode source is combined with a high-resolution detector and an absorbing mask to obtain attenuation, phase, and ultra-small-angle scattering tomograms of different specimens. A theoretical model is also presented which justifies the implementation of beam tracking with polychromatic sources and provides quantitative values of attenuation and phase, under the assumption of low sample attenuation. The method is tested on a variety of samples featuring both large and small x-ray attenuation, phase, and scattering signals. The complementarity of the contrast channels can enable subtle distinctions between materials and tissue types, which appear indistinguishable to conventional tomography scanners.

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  • Received 30 August 2017

DOI:https://doi.org/10.1103/PhysRevApplied.8.064009

Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.

Published by the American Physical Society

Physics Subject Headings (PhySH)

Condensed Matter, Materials & Applied Physics

Authors & Affiliations

Fabio A. Vittoria1,*, Marco Endrizzi1, Gibril K. Kallon1, Charlotte K. Hagen1, Francesco Iacoviello2, Paolo De Coppi3, and Alessandro Olivo1

  • 1Department of Medical Physics and Biomedical Engineering, University College London, Malet Place, Gower Street, London WC1E 6BT, United Kingdom
  • 2Electrochemical Innovation Lab, Department of Chemical Engineering, University College London, London WC1E 7JE, United Kingdom
  • 3Institute of Child Health, University College London, London WC1N 1EH, United Kingdom

  • *fabio.vittoria.12@ucl.ac.uk

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Issue

Vol. 8, Iss. 6 — December 2017

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