This study aimed to improve the safety and economy of cement production and to investigate the gasification performance and tar properties of wheat straw in a small electrically heated bubbling fluidized bed by varying three factors, namely, gasification reaction conditions, fuel quality and type, and the natural environment, so as to promote the application of the low-temperature gasification of biomass in the cement industry. The gasification experiment was carried out at temperatures of 550–700 °C, air equivalence ratios of 0.1–0.2, moisture contents of 5.25–24%, blended rubber ratios of 0–100%, and furnace vacuums of 0–0.03 within the parameter ranges, and the component analyses of the produced gases and tars were carried out by gas chromatography (GC) and gas chromatography–mass spectrometry (GC-MS). The experimental findings revealed that the optimal operating conditions for gasification were attained at a temperature of 650 °C, an equivalence ratio of 0.15, a moisture content of 5.25%, a rubber blending ratio of 0, and a vacuum degree of 0. Under these conditions, the concentrations of combustible components (H₂, CH₄, and CO) in the produced gas were 4.01%, 4.60%, and 21.05%, respectively. The carbon conversion rate was 62.40%, with the cold gas efficiency of 39.37%. The lower heating value of the produced gas was 5.915 MJ/Nm³, accompanied by a tar yield of 118.15 g/Nm³ and lower heating value of 3.385 MJ/Nm³. Full article

School-based outbreaks often precede increased incidence of acute respiratory infections in the greater community. We conducted acute respiratory infection surveillance among children to elucidate commonly detected pathogens in school settings and their unique characteristics and epidemiological patterns. The ORegon CHild Absenteeism due to Respiratory Disease Study (ORCHARDS) is a longitudinal, laboratory-supported, school-based, acute respiratory illness (ARI) surveillance study designed to evaluate the utility of cause-specific student absenteeism monitoring for early detection of increased activity of influenza and other respiratory viruses in schools from kindergarten through 12th grade. Eligible participants with ARIs provided demographic, epidemiologic, and symptom data, along with a nasal swab or oropharyngeal specimen. Multipathogen testing using reverse-transcription polymerase chain reaction (RT-PCR) was performed on all specimens for 18 respiratory viruses and 2 atypical bacterial pathogens (Chlamydia pneumoniae and Mycoplasma pneumoniae). Between 5 January 2015 and 9 June 2023, 3498 children participated. Pathogens were detected in 2455 of 3498 (70%) specimens. Rhinovirus/enteroviruses (36%) and influenza viruses A/B (35%) were most commonly identified in positive specimens. Rhinovirus/enteroviruses and parainfluenza viruses occurred early in the academic year, followed by seasonal coronaviruses, RSV, influenza viruses A/B, and human metapneumovirus. Since its emergence in 2020, SARS-CoV-2 was detected year-round and had a higher median age than the other pathogens. A better understanding of the etiologies, presentations, and patterns of pediatric acute respiratory infections can help inform medical and public health system responses. Full article

Natural disasters devastate property and infrastructure systems, impeding sustainable development. Low-income communities, due to economic, physical, and social disparities, face heightened exposure and vulnerability. These communities endure severe and long-lasting infrastructure damage, experiencing a fourfold increase in deaths per disaster and delayed recovery efforts. Consequently, they resort to constructing informal housing and infrastructure, worsening post-disaster challenges and vulnerabilities. This study aims to address post-disaster challenges in low-income communities by proposing two novel approaches that remain understudied despite their significant potential: (1) a short-term solution of origami temporary emergency housing for swift shelter post-disaster, enabling a return to routine activities while homes and infrastructure systems are being repaired or rebuilt; and (2) a long-term solution, including effective pedagogy, such as teaching methods and instructional tools, to educate and train low-income individuals to aid in sustainable post-disaster reconstruction while providing the added benefit of social mobility. To validate the feasibility of origami TEH and the need and effectiveness of the pedagogy, a survey among architecture, engineering, and construction experts in Puerto Rico, a region prone to natural disasters, was conducted. The results, analyzed using statistical measures including descriptive statistics and ordered probit regression analysis, emphasize the urgent need for sustainable TEH that can be quickly assembled and education for low-income individuals in construction trades. Implementing these solutions will significantly impact communities by addressing post-disaster challenges and promoting social mobility and job equity. Full article

Within the food sector, there is a growing embrace of meat substitutes as a more sustainable alternative to meat, driven by ethical, environmental, and health considerations. This study aims to explore consumer behavior and willingness to pay (WTP) for plant-based meat alternatives (PBMAs), illustrated by the example of vegan burger patties. The sample of the study (n = 433) consists of young consumers roughly below 30 years of age, known as Generation Z (Gen Z). The study aims to (1) assess of the importance of PBMA attributes to Gen Z, and (2) approximate Gen Z’s willingness to pay for specific PBMA attribute levels. A choice-based conjoint analysis was used to assess Gen Z’s preferences for meat substitutes. The findings indicate that the most crucial PBMA attribute is origin, followed by price and the primary vegan ingredient. Notably, Gen Z values domestic and EU-sourced products positively, contrasting with the negative perception of third-country imports. Organic production is associated with a positive part-worth utility, whereas the attribute fat content has almost no impact. Consequently, WTP is approximated to be the highest for products of domestic origin compared to the significant discount required for non-EU origin. All other attribute levels have a much lower impact. Despite sociodemographic variables, the respondents’ eating habits (vegan, vegetarian, etc.) most significantly influence the approximation of the importance of some of the PBMA attributes, in particular price and primary ingredient. Full article

Transient stability preventive control (TSPC), a method to efficiently withstand the severe contingencies in a power system, is mathematically a transient stability constrained optimal power flow (TSC-OPF) issue, attempting to maintain the economical and secure dispatch of a power system via generation rescheduling. The traditional TSC-OPF issue incorporated with differential-algebraic equations (DAE) is time consumption and difficult to solve. Therefore, this paper proposes a new TSPC method driven by a naturally inspired optimization algorithm integrated with transient stability assessment. To avoid solving complex DAE, the stacking ensemble multilayer perceptron (SEMLP) is used in this research as a transient stability assessment (TSA) model and integrated into the optimization algorithm to replace transient stability constraints. Therefore, less time is spent on challenging calculations. Simultaneously, sensitivity analysis (SA) based on this TSA model determines the adjustment direction of the controllable generators set. The results of this SA can be utilized as prior knowledge for subsequent optimization algorithms, thus further reducing the time consumption process. In addition, a naturally inspired algorithm, Aptenodytes Forsteri Optimization (AFO), is introduced to find the best operating point with a near-optimal operational cost while ensuring power system stability. The accuracy and effectiveness of the method are verified on the IEEE 39-bus system and the IEEE 300-bus system. After the implementation of the proposed TSPC method, both systems can ensure transient stability under a given contingency. The test experiment using AFO driven by SEMLP and SA on the IEEE 39-bus system is completed in about 35 s, which is one-tenth of the time required by the time domain simulation method. Full article

This study presents an updated view of the effects of the 1940 Vrancea earthquake. Recently compiled studies in the literature from the time of the event, as well as other studies, present the opportunity to gain additional and relevant information regarding this large-magnitude event. The effects of this earthquake on various locations in Romania are compared to those observed after the subsequent large Vrancea earthquake of 1977. An assessment of the economic losses caused by the seismic event is also attempted. The seismic vulnerability of some building typologies commonly used before 1940 is assessed by employing the earthquake damage data and the well-known macroseismic method. The impact of this event on the design and construction practices in Romania is evaluated using the collected information as well. Finally, the policy of repair and strengthening of buildings applied after the event is also discussed, and case studies are presented. Full article

The present study examined temporal variations in water and sediment discharges in the Red River basin from 1958 to 2021 resulting from climate change and anthropogenic factors, with projections extended to 2100. The 64-year observational period was divided into five distinct stages: 1958–1971 (Stage I: natural conditions); 1972–1988 (Stage II: onset of human activities); 1989–2010 (Stage III: post Hoa Binh dam construction); 2011–2016 (Stage IV: series of new dam constructions); and 2017–2021 (Stage V: combined effects of human activities and climate change). Attribution analysis revealed that human activities accounted for 62% and 92% of the dramatic declines in sediment loads in Stages III and IV, respectively. Projection results of fluvial sediment loads over an approximate 150-year timeframe (1958–2100) indicate an overriding impact from human activities. Climate change projections based on four scenarios (−5%, +5%, +10%, and +15% change per year) suggest associated decreases or increases in river flows. This study predicts that projected 21st century increases in river flow attributable to climate change will offset up to eight percent of the human-induced sediment load deficit. Full article

In this paper, multi-band bandstop filters (BSFs) based on mixed electric and magnetic coupling resonators are proposed. These proposed structures include a multimode resonator based on symmetrical open-circuit branches, including upper- and lower-branch filter circuits. Through this design, the center frequencies of the stopbands can be flexibly and autonomously adjusted. In addition, the filters proposed in this paper have excellent characteristics, such as miniature dimensions and abrupt roll-off skirts. Finally, these tri-band to sext-band bandstop filters were fabricated and the measured results agreed well with the simulated ones. The proposed structures can be applied in the fields of communication, information, and coal automation. Full article

In August 2020, the unusual appearance of crown gall symptoms was observed on the tobacco plants (hybrid PVH2310) grown in fields in the Golubinci (Srem district, Serbia) locality. The causal agent isolated from galls located on tobacco roots formed circular, convex, and glistening light blue colonies, and then dark to olive-green-colored bacterial colonies on a semi-selective D1 medium. Molecular analysis based on multiplex PCR and multi-locus sequence analysis (MLSA) using concatenated sequences of the atpD, dnaK, glnA, and rpoB genes as well as 16S rRNA identified Serbian tobacco isolates such as Agrobacterium tumefaciens (biovar 1). Two duplex PCR methods confirmed the presence of the virD2 and virC genes in tobacco isolates. Pathogenicity tests performed on carrot discs and squash fruits resulted in tumor/gall formation after 12 to 16 days post inoculation, respectively. Pathogenicity was also confirmed on tobacco plants, where isolates caused tumor development 21−25 days after inoculation. API 50 CH generated results regarding the biochemical features of the Serbian tobacco isolates. As A. tumefaciens (biovar 1) as a cause of tobacco crown gall has previously been documented solely in Japan, there is presently no data on its wider occurrence. Therefore, this first detailed investigation of A. tumefaciens isolated from naturally infected tobacco in Serbia will contribute to a better understanding of it at the global level. Full article

Per- and polyfluoroalkyl substances (PFASs) are carbon–fluorine compounds with widespread industrial and domestic use, posing potential toxicological risks to humans and ecosystems. Several analytical methods have been developed to assess the occurrence of PFASs in the environment, but a standardized method, applicable to all matrices, is still lacking. This paper reviews the extraction and chromatographic detection methods for PFAS assessment in environmental samples, considering parameters such as the LOD, LOQ, and recoveries. Solid phase extraction (SPE) is commonly used, showing high recovery rates for water, soil, and sediment samples using HBL and WAX polymeric sorbents (85–100% and 93–111.5%, respectively). LC-MS has demonstrated low LODs and LOQs in seawater (0.01–0.08 ng L⁻¹; 0.03–0.24 ng L⁻¹), marine sediment (0.002–0.018 ng g⁻¹; 0.004–0.054 ng g⁻¹), and dust (0.08–0.68 pg g⁻¹; 0.26–2.25 pg g⁻¹), indicating its sensitivity when detecting trace PFAS levels. Evaluating PFASs is crucial for the development of future removal strategies and risk assessments. Potential solutions including the use of PFAS substitutes and innovative adsorption techniques for their adsorption could present promise in reducing their environmental presence. Full article

Hildegard of Bingen (1098–1179) was a medieval mystic. From a young age, she had many colorful visions and became well known and influential not only in her own time but in ours as well. Her music reached the mellow house scene in the 1990s, reviving Hildegard’s spirituality for people today. In this paper, I will approach Hildegard as a philosophical practitioner and conduct an imaginary philosophical consultation. I will study her biography, listen to her words by some authentic text fragments and propose a spiritual exercise on her music in order not to just think about Hildegard of Bingen but to try and think like Hildegard of Bingen, in line with the principles of philosophical practice. This way, I will try to understand Hildegard in a practical way and not (just) annotate the regular (theoretical) interpretations of her life. I will distinguish three phases in her life as movements towards spirituality: (1) her relationship with the world, (2) her relationship with God, and (3) her relationship with herself as a spiritual being. I will argue that her life is an example of a philosophical life. Hildegard’s “not fitting in any place” (being átopos) and her development define such a life as a path towards an authentic self, attained by spirituality. The paper intends to contribute both to the understanding of philosophical consultations and to the understanding of Hildegard of Bingen. Full article

Poor surface quality is one of the drawbacks of metal parts made by additive manufacturing (AM)—they normally possess relatively high surface roughness and different types of surface irregularities. Post-processing operations are usually needed to reduce the surface roughness to have ready-to-use parts. Among all the surface treatment techniques, electrochemical polishing has the highest finishing efficiency and flexibility. However, although the average surface roughness can be reduced effectively (more than 80% roughness reduction), large-scale surface waviness still remains an issue when finishing metal AM parts. To maintain the finishing efficiency while reducing the surface waviness, a novel hybrid surface finishing technique is designed, which involves the combination of electropolishing, ultrasonic vibration, and abrasion. Preliminary experiments to prove the feasibility of novel hybrid finishing methods were conducted on Ti6Al4V coupons manufactured via laser powder bed fusion (LPBF). Electropolishing, a combination of ultrasound and abrasion, and hybrid finishing were conducted for process optimization and comparison purposes. The effects of the voltage, inter-electrode gap, temperature, ultrasonic amplitude, abrasive concentration, and processing time were studied and optimized. When similar optimal arithmetic mean height values (Sa ≈ 1 μm) are achieved for both processes, the arithmetic mean waviness values (Wa) obtained from hybrid finishing are much less than those from sole electropolishing after the same processing time, with the amount being 61.7% less after 30 min and 40.0% after 45 min. Full article

Long-acting injectable (LAI) formulations provide sustained drug release over an extended period ranging from weeks to several months to improve efficacy, safety, and compliance. Nevertheless, many challenges arise in the development and regulatory assessment of LAI drug products due to a limited understanding of the tissue response to injected particles (e.g., inflammation) impacting in vivo performance. Mechanism-based in silico methods may support the understanding of LAI–physiology interactions. The objectives of this study were as follows: (1) to use a mechanistic modeling approach to delineate the in vivo performance of DepoSubQ Provera^® and formulation variants in preclinical species; (2) to predict human exposure based on the knowledge gained from the animal model. The PBPK model evaluated different elements involved in LAI administration and showed that (1) the effective in vivo particle size is potentially larger than the measured in vitro particle size, which could be due to particle aggregation at the injection site, and (2) local inflammation is a key process at the injection site that results in a transient increase in depot volume. This work highlights how a mechanistic modeling approach can identify critical physiological events and product attributes that may affect the in vivo performance of LAIs. Full article

Fatigue is a common non-motor symptom in Parkinson’s disease (PD), but even so, it may still be underdiagnosed or misdiagnosed in current practice due to its non-specific manifestations. The aims of this study were to investigate the prevalence of fatigue in PD patients compared to healthy controls and to identify the main characteristics and associations of fatigue with other non-motor symptoms and the impact of fatigue on sleep disturbances in Parkinson’s disease. Materials and methods: case–control study in which 131 PD patients and 131 age- and sex-matched controls were enrolled. Main characteristics of fatigue, sleep, and other non-motor symptoms were assessed using specific validated questionnaires. Results: According to the Chalder fatigue scale, fatigue is more prevalent in PD patients (38.16%) compared to healthy controls (26.71%). Fatigue was identified in 46.54% of the PD patients using the Parkinson’s Fatigue Scale (PFS-16). PD patients with fatigue presented a worse motor status, more sleep disturbances (insomnia, daytime sleepiness), a broader spectrum of non-motor symptoms (pain, anxiety, urinary disturbances), worse cognitive performances, a lower level of happiness, and worse quality of life compared to PD patients without fatigue. Conclusion: Fatigue is a common symptom of PD and needs to be assessed, considering its consequences on quality of life. Sleep disturbances have a great influence over fatigue in PD patients. Full article

Neuroplasticity in the central nucleus of the amygdala (CeA) plays a key role in the modulation of pain and its aversive component. The dynorphin/kappa opioid receptor (KOR) system in the amygdala is critical for averse-affective behaviors in pain conditions, but its mechanisms are not well understood. Here, we used chemogenetic manipulations of amygdala KOR-expressing neurons to analyze the behavioral consequences in a chronic neuropathic pain model. For the chemogenetic inhibition or activation of KOR neurons in the CeA, a Cre-inducible viral vector encoding Gi-DREADD (hM4Di) or Gq-DREADD (hM3Dq) was injected stereotaxically into the right CeA of transgenic KOR-Cre mice. The chemogenetic inhibition of KOR neurons expressing hM4Di with a selective DREADD actuator (deschloroclozapine, DCZ) in sham control mice significantly decreased inhibitory transmission, resulting in a shift of inhibition/excitation balance to promote excitation and induced pain behaviors. The chemogenetic activation of KOR neurons expressing hM3Dq with DCZ in neuropathic mice significantly increased inhibitory transmission, decreased excitability, and decreased neuropathic pain behaviors. These data suggest that amygdala KOR neurons modulate pain behaviors by exerting an inhibitory tone on downstream CeA neurons. Therefore, activation of these interneurons or blockade of inhibitory KOR signaling in these neurons could restore control of amygdala output and mitigate pain. Full article

Joining structural components with mechanical fasteners is common in many engineering applications across all industries. This study investigates combining additive manufactured inserts with sandwich composites consisting of aluminum honeycomb cores with carbon fiber reinforced facesheets. The combination of these components offers an integrated, lightweight solution when mechanically fastening sandwich composite components using bolted joints. The experimental and numerical investigation explores the influence insert geometry has on the structural response of a sandwich composite under pull-through load scenarios. Various failure modes are observed during experimental analysis with facesheet debonding being the initial failure mode. In addition, finite element models investigate the stress fields in the honeycomb core and overall panel deflections, validating the mechanics observed experimentally. When comparing additively manufactured inserts to standard inserts, additively manufactured inserts have increases in stiffness, maximum force, and total energy absorption of 7.1%, 53.0%, and 62.3%, respectively. These results illustrate the potential of an integrated approach to mechanical joint technology by combining additively manufactured inserts with sandwich composite components using aluminum honeycomb cores. Full article

The consumption of functional foods in a daily diet is a promising approach for the maintenance of cognitive health. The present study examines the effects of water-soluble prebiotic dietary-fiber, partially hydrolyzed guar gum (PHGG), on cognitive function and mental health in healthy elderly individuals. Participants consumed either 5 g/day of PHGG or a placebo daily for 12 weeks in this randomized, double-blind, placebo-controlled, and parallel-group study. An assessment of cognitive functions, sleep quality, and subjective mood evaluations was performed at baseline and after 8 and 12 weeks of either PHGG or placebo intake. The visual memory scores in cognitive function tests and sleepiness on rising scores related to sleep quality were significantly improved in the PHGG group compared to the placebo group. No significant differences were observed in mood parameters between the groups. Vigor–activity scores were significantly improved, while the scores for Confusion–Bewilderment decreased significantly in the PHGG group when compared to the baseline. In summary, supplementation with PHGG was effective in improving cognitive functions, particularly visual memory, as well as enhancing sleep quality and vitality in healthy elderly individuals (UMIN000049070). Full article

PIPAC is a new and promising technique for the intraperitoneal administration of chemotherapy. It can be used in patients with various peritoneal cancer metastases. It is mainly a palliative treatment, but there is some neoadjuvant treatment potential. We have operated on 41 patients with various intra-abdominal cancers. PIPAC was performed every 6 weeks. The indication was extension of peritoneal carcinomatosis beyond the criteria for cytoreductive surgery and HIPEC. The effect was evaluated according to the peritoneal cancer index, the peritoneal regression grading score and the amount of ascites. Complications were classified according to the Clavien-Dindo system. We have performed 100 PIPAC procedures. There were two major complications, classified as Clavien Dindo III (2%). The number of procedures varied from 1 to 6. Five patients switched to cytoreductive surgery and HIPEC, and one was indicated for the watch and wait strategy due to total regression according to PRGS. Three patients are still continuing treatment. The others stopped treatment mainly because of progression of the disease and loss of metastases. We observed a reduction in ascites production soon after PIPAC application. PIPAC is a safe and well-tolerated treatment modality. It is mainly a palliative treatment that can improve the quality of life by reducing the production of ascites, but in about 10% of cases, it can reduce the extent of the disease and allow for further radical treatment. Full article

Neural machine translation (NMT) typically relies on a substantial number of bilingual parallel corpora for effective training. Mongolian, as a low-resource language, has relatively few parallel corpora, resulting in poor translation performance. Data augmentation (DA) is a practical and promising method to solve problems related to data sparsity and single semantic structure by expanding the size and structure of available data. In order to address the issues of data sparsity and semantic inconsistency in Mongolian–Chinese NMT processes, this paper proposes a new semantic-context DA method. This method adds an additional semantic encoder based on the original translation model, which utilizes both source and target sentences to generate different semantic vectors to enhance each training instance. The results show that this method significantly improves the quality of Mongolian–Chinese NMT tasks, with an increase of approximately 2.5 BLEU values compared to the basic Transformer model. Compared to the basic model, this method can achieve the same translation results with about half of the data, greatly improving translation efficiency. Full article

Deep learning-based models have achieved impressive results across various practical fields. However, these models are susceptible to attacks. Recent research has demonstrated that adversarial samples can significantly decrease the accuracy of deep learning models. This susceptibility poses considerable challenges for their use in security applications. Various methods have been developed to enhance model robustness by training with more effective and generalized adversarial examples. However, these approaches tend to compromise model accuracy. Currently proposed detection methods mainly focus on speech adversarial samples generated by specified white-box attack models. In this study, leveraging manifold learning technology, a method is proposed to detect whether a speech input is an adversarial sample before feeding it into the recognition model. The method is designed to detect speech adversarial samples generated by black-box attack models and achieves a detection success rate of 84.73%. It identifies the low-dimensional manifold of training samples and measures the distance of a sample under investigation to this manifold to determine its adversarial nature. This technique enables the preprocessing detection of adversarial audio samples before their introduction into the deep learning model, thereby preventing adversarial attacks without affecting model robustness. Full article

The retinoblastoma (RB) transcriptional corepressor 1 (RB1) is a critical tumor suppressor gene, governing diverse cellular processes implicated in cancer biology. Dysregulation or deletion in RB1 contributes to the development and progression of various cancers, making it a prime target for therapeutic intervention. RB1′s canonical function in cell cycle control and DNA repair mechanisms underscores its significance in restraining aberrant cell growth and maintaining genomic stability. Understanding the complex interplay between RB1 and cellular pathways is beneficial to fully elucidate its tumor-suppressive role across different cancer types and for therapeutic development. As a result, investigating vulnerabilities arising from RB1 deletion-associated mechanisms offers promising avenues for targeted therapy. Recently, several findings highlighted multiple methods as a promising strategy for combating tumor growth driven by RB1 loss, offering potential clinical benefits in various cancer types. This review summarizes the multifaceted role of RB1 in cancer biology and its implications for targeted therapy. Full article