ExLibris header image
SFX Logo
Title: The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
Source:

Proceedings of the National Academy of Sciences of the United States of America [0027-8424] Engel, M yr:2003


Collapse list of basic services Basic
Full text
Full text available via PubMed Central
GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. Pei, Z. "Discovery and Structure-Activity Relationships of Piperidinone- and Piperidine-Constrained Phenethylamines as Novel, Potent, and Selective Dipeptidyl Peptidase IV Inhibitors." Journal of medicinal chemistry 50.8 (2007): 1983-7. Link to Full Text for this item Link to SFX for this item
2. Oefner, C. "High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine." Acta crystallographica. Section D, Biological crystallography 59.Pt 7 (2003): 1206-1212. Link to Full Text for this item Link to SFX for this item
3. Rasmussen, Hanne B B. "Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog." Nature structural biology 10.1 (2002): 19-25. Link to Full Text for this item Link to SFX for this item
4. Aertgeerts, Kathleen J. "Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation." Protein science 13.2 (2004): 412-21. Link to Full Text for this item Link to SFX for this item
5. Ghate, Manjunath D. "Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors." European journal of medicinal chemistry 74 (2014): 574-605. Link to SFX for this item
6. Wang, Y. "Attenuation of Renovascular Damage in Zucker Diabetic Fatty Rat by NWT-03, an Egg Protein Hydrolysate with ACE- and DPP4-Inhibitory Activity." PLoS ONE 7.10 (2012): 1-. Link to Full Text for this item Link to SFX for this item
7. Thoma, R. "Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV." Structure 11.8 (2003): 947-59. Link to SFX for this item
8. Deacon, C F F. "Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig." Diabetes 47.5 (1998): 764-9. Link to SFX for this item
9. Sebokova, E. "Dipeptidyl Peptidase IV Inhibitors: The Next Generation of New Promising Therapies for the Management of Type 2 Diabetes." Current topics in medicinal chemistry 7.6 (2007): 547-55. Link to SFX for this item
10. Essen, W. "The beta-propeller domain of the trilobed protease from Pyrococcus furiosus reveals an open Velcro topology." Acta crystallographica. Section D, Biological crystallography (2007): 179-87. Link to Full Text for this item Link to SFX for this item
11. Brana, Miguel F. "Synthesis of new 4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine derivatives." Journal of heterocyclic chemistry 40.5 (2003): 917-923. Link to Full Text for this item Link to SFX for this item
12. BACKES, Bradley J. "Pyrrolidine-constrained phenethylamines: The design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit." Bioorganic & medicinal chemistry letters 17.7 (2007): 2005-2012. Link to SFX for this item
13. Pei, Z. "Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibi." Journal of medicinal chemistry 49.22 (2006): 6439-42. Link to Full Text for this item Link to SFX for this item
14. Feng, J. "Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV." Journal of medicinal chemistry 50.10 (2007): 2297-300. Link to Full Text for this item Link to SFX for this item
15. CYWIN, Charles L. "Discovery of potent and selective PKC-θ inhibitors." Bioorganic & medicinal chemistry letters 17.1 (2007): 225-62. Link to SFX for this item
16. Nathan, David M M. "Finding new treatments for diabetes--how many, how fast... how good?" The New England journal of medicine 356.5 (2007): 437-40. Link to SFX for this item
17. Mintz, Matthew L L. "New treatments for diabetes." The New England journal of medicine 356.21 (2007): 2221-2. Link to SFX for this item
18. Lambeir, A M M. "Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion." FEBS letters 507.3 (2001): 327-30. Link to Full Text for this item Link to SFX for this item
19. Krentz, Andrew J J. "Oral antidiabetic agents - Current role in type 2 diabetes mellitus." Drugs 65.3 (2005): 385-411. Link to SFX for this item
20. Lambert, Marie-Laurence L. "Rimonabant in obese patients with type 2 diabetes." The lancet 369.9561 (2007): 553-5. Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced
A service provided by the Library of the Wissenschaftspark Albert Einstein, Potsdam, Germany.
© 2005 SFX by Ex Libris Inc.