SFX by Ex Libris Inc.

Title:	Design and Mechanism of Tetrahydrothiophene-Based γ-Aminobutyric Acid Aminotransferase Inactivators
Source:	Journal of the American Chemical Society [0002-7863] Le, Hoang yr:2015

Basic

Full text

Full text available via American Chemical Society Journals

Year:

Volume:

Issue:

Start Page:

Document delivery

Request document via Library/Bibliothek

Users interested in this article also expressed an interest in the following:
description	1.	"Mechanism-based inactivation of benzoylformate decarboxylase, A thiamin diphosphate-dependent enzyme.(Report)." Journal of the American Chemical Society. 129.14: 4120-.
description	2.	Lee, H. "Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid." ACS chemical biology 10.9 (2015): 2087-2098.
description	3.	Lee, H. "Mechanism of inactivation of gamma-aminobutyric acid aminotransferase by (1S,3S)-3-amino-4-difluoromethylene-1-cyclopentanoic acid (CPP-115)." Journal of the American Chemical Society 137.7 (2015): 2628-2640.
description	4.	"Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction." Journal of the American Chemical Society 140.6: 2151-2164.
description	5.	Anand, P. "A review on cholinesterase inhibitors for Alzheimer's disease." Archives of pharmacal research 36.4 (2013): 375-399.
description	6.	Brandt, Gabriel S. "Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition." Journal of the American Chemical Society 132.2 (2010): 438-439.
description	7.	Yep, A. "Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism." Proceedings of the National Academy of Sciences of the United States of America 105.15 (2008): 5733-5738.
description	8.	Zhang, L. "Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase." Bioorganic & medicinal chemistry 16.1 (2008): 303-312.
description	9.	Sharma, K. "Cholinesterase inhibitors as Alzheimer's therapeutics (Review)." Molecular Medicine Reports 20.2 (2019): 1479-1487.
description	10.	Deardorff, William J. "The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer’s Disease." Drugs & aging 32.19 (2015): 537-547.
description	11.	Gauthier, S. "Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease." Alzheimer's & dementia 9.3 (2012): 326-331.
description	12.	Anand, P. "A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease." Bioorganic & medicinal chemistry 20.3 (2012): 1175-1180.
description	13.	Shi, C. "Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in mycobaterium tuberculosis." Journal of the American Chemical Society 133.45 (2011): 18194-18201.
description	14.	Ugwumba, Isaac N. "Improving a Natural Enzyme Activity through Incorporation of Unnatural Amino Acids." Journal of the American Chemical Society 133.2 (2011): 326-333.
description	15.	Davis, L. "Quantum chemical study of the mechanism of action of vitamin K carboxylase (VKC). IV. Intermediates and transition states." The journal of physical chemistry. A 111.31 (2007): 7257-7261.
description	16.	Mansell, Mansell J. "A rapid protein folding assay for the bacterial periplasm." Protein science 19.5 (2010): 1079-1090.
description	17.	Brandt, Gabriel S. "Probing the Active Center of Benzaldehyde Lyase with Substitutions and the Pseudosubstrate Analogue Benzoylphosphonic Acid Methyl Esterâ ." Biochemistry 47.29 (2008): 7734-7743.
description	18.	Kokova, M. "Investigation of the carboligase activity of thiamine diphosphate-dependent enzymes using kinetic modeling and NMR spectroscopy." Journal of molecular catalysis. B, Enzymatic 61.1-2 (2009): 73-79.
description	19.	Romo, A. "Treatment options in insulin resistance obesity-related acanthosis nigricans." The Annals of pharmacotherapy 42.7-8 (2008): 1090-4.
description	20.	Fu, Nanyan Y. "Facile synthesis of phosphonamidate- and phosphonate-linked phosphonopeptides." Journal of peptide science 12.4 (2006): 303-309.