ExLibris header image
SFX Logo
Title: Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models
Source:

Journal of Medicinal Chemistry [0022-2623] Cowart, Marlon yr:2008


Collapse list of basic services Basic
Full text
Full text available via American Chemical Society Journals
GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. Altenbach, R. "Structure-Activity Studies on a Series of a 2-Aminopyrimidine-Containing Histamine H-4 Receptor Ligands." Journal of medicinal chemistry 51.20 (2008): 6571-6580. Link to Full Text for this item Link to SFX for this item
2. Harris, J. "Potent and selective adenosine A(2A) receptor antagonists: [1,2,4]-triazolo[4,3-c]pyrimidin-3-ones." Bioorganic and medicinal chemistry letters 21.8 (2011): 2497-2501. Link to SFX for this item
3. Strakhova, M. "Localization of histamine H-4 receptors in the central nervous system of human and rat." Brain Research 1250 (2009): 41-48. Link to SFX for this item
4. Lim, H. "Phenylalanine 169 in the second extracellular loop of the human histamine H-4 receptor is responsible for the difference in agonist binding between human and mouse H-4 receptors." The Journal of pharmacology and experimental therapeutics 327.1 (2008): 88-96. Link to SFX for this item
5. Smits, R.A. A. "Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives." Journal of medicinal chemistry 49.15 (2006): 4512-4516. Link to Full Text for this item Link to SFX for this item
6. Matasi, J. "2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs: Highly potent, orally active, adenosine A2A antagonists. Part 1." Bioorganic & medicinal chemistry letters 15.16 (2005): 3670-3674. Link to SFX for this item
7. Jablonowski, Jill A. "The First Potent and Selective Non-Imidazole Human Histamine H4 Receptor Antagonists." Journal of medicinal chemistry 46.19 (2003): 3957-3960. Link to Full Text for this item Link to SFX for this item
8. Karlstedt, K. "Expression of histamine receptor Hrh3 and Hrh4 in rat brain endothelial cells." British Journal of Pharmacology 170.1 (2013): 58-66. Link to Full Text for this item Link to SFX for this item
9. Leite-de-Moraes, Maria C C. "Cutting edge: histamine receptor H4 activation positively regulates in vivo IL-4 and IFN-gamma production by invariant NKT cells." The journal of immunology 182.3 (2009): 1233-1236. Link to SFX for this item
10. Murray, Christopher W. "Fragment-based drug discovery applied to Hsp90. Discovery of two lead series with high ligand efficiency." Journal of medicinal chemistry 53.16 (2010): 5942-55. Link to Full Text for this item Link to SFX for this item
11. Bhat, K. "Synthesis and antitumor activity studies of some new fused 1,2,4-triazole derivatives carrying 2,4-dichloro-5-fluorophenyl moiety." European Journal of Medicinal Chemistry 44.12 (2009): 5066-70. Link to SFX for this item
12. Riihimaki-Lampen, L. "The Binding of Synthetic Retinoids to Lipocalin beta-Lactoglobulins." Journal of medicinal chemistry 53.1 (2010): 514-518. Link to Full Text for this item Link to SFX for this item
13. Brown, David S. "Epoxidation with dioxiranes derived from 2-fluoro-2-substituted-1-tetralones and -1-indanones." Tetrahedron 51.12 (1995): 3587-3606. Link to Full Text for this item Link to SFX for this item
14. Terzioglu, N. "Snythesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H-4 receptor antagonists." Bioorganic & medicinal chemistry letters 14.21 (2004): 5251-5256. Link to SFX for this item
15. De Souza-Silva, M A A. "Episodic-like and procedural memory impairments in histamine H1 Receptor knockout mice coincide with changes in acetylcholine esterase activity in the hippocampus and dopamine turnover in the cerebellum." Neuroscience 157.3 (2009): 532-41. Link to SFX for this item
16. Youssouf, M. "Anti-histaminic, anti-inflammatory and bronchorelaxant activities of 2,7-dimethyl-3-nitro-4H pyrido[1,2-a]pyrimidine-4-one." International immunopharmacology 8.7 (2008): 1049-1055. Link to SFX for this item
17. Miao, J. "Histone lysine methyltransferases and demethylases in Plasmodium falciparum." International Journal for Parasitology 38.10 (2008): 1083-1097. Link to SFX for this item
18. Schwarzschild, Michael A A. "Targeting adenosine A2A receptors in Parkinson's disease." Trends in Neurosciences 29.11 (2006): 647-54. Link to SFX for this item
19. Theoharides, Theoharis C. "Critical role of mast cells in inflammatory diseases and the effect of acute stress." Journal of neuroimmunology 146.1-2 (2003): 1-12. Link to SFX for this item
20. Smits, R.A. A. "Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo." Journal of medicinal chemistry 51.8 (2008): 2457-2467. Link to Full Text for this item Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced