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Title:	9H-Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain
Source:	Journal of Medicinal Chemistry [0022-2623] Picaud, Sarah yr:2015

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description	13.	Tao, Z. "Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors." Journal of medicinal chemistry 50.7 (2007): 1514-4.
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description	16.	Karim, Rezaul M. "An Advanced Tool To Interrogate BRD9." Journal of medicinal chemistry 59.10 (2016): 4459-4461.
description	17.	Wang CY, C. "Beating the odds: BETs in disease." Trends in biochemical sciences 40.8 (2015): 468-79.
description	18.	Jung, M. "Targeting BET bromodomains for cancer treatment." Epigenomics 7.3 (2015): 487-501.
description	19.	Healy, Alan R. "Stereochemical Assignment of the Protein-Protein Interaction Inhibitor JBIR-22 by Total Synthesis." Angewandte Chemie (International ed.) 54.13 (2015): 4046-4050.
description	20.	Harner, Mary J. "Fragment-Based Screening of the Bromodomain of ATAD2." Journal of medicinal chemistry 57.22 (2014): 4294967295-9692.