ExLibris header image
SFX Logo
Title: Discovery of Clinical Candidate 1-(4-(3-(4-(1H-Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)
Source:

Journal of Medicinal Chemistry [0022-2623] Hu, Essa yr:2014


Collapse list of basic services Basic
Full text
Full text available via American Chemical Society Journals
GO
Document delivery
Request document via Library/Bibliothek GO
Users interested in this article also expressed an interest in the following:
1. García-Barroso, C. "Phosphodiesterase Inhibition in Cognitive Decline." Journal of Alzheimer's disease 42.s4 (2014): -73. Link to SFX for this item
2. Chen Jian Jeffrey, Jian n. "Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease." Bioorganic and medicinal chemistry letters 23.23 (2013): 6447-6454. Link to SFX for this item
3. Carlier, P. "Axial-Selective H/D Exchange of Glycine-Derived 1H-Benzo[e][1,4]diazepin-2(3H)-ones: Kinetic and Computational Studies of Enantiomerization." Journal of organic chemistry 75.19 (2010): 6588-6594. Link to Full Text for this item Link to SFX for this item
4. Xie, X. "Synthesis and anticancer effects evaluation of 1-alkyl-3-(6-(2-methoxy-3-sulfonylaminopyridin-5-yl)benzo[d]thiazol-2-yl)urea as anticancer agents with low toxicity." Bioorganic & medicinal chemistry 23.19 (2015): 6477-6485. Link to SFX for this item
5. Gonzalez Lima, F. "Mitochondrial respiration as a target for neuroprotection and cognitive enhancement." Biochemical pharmacology 88.4 (2014): 584-593. Link to SFX for this item
6. Chavez, F. "Influence of extended interactions on the surface dynamics in the catalytic CO oxidation on Pt single crystal substrate." The Journal of chemical physics 112.19 (2000): 8672-8679. Link to Full Text for this item Link to SFX for this item
7. Sanders, L. "Cancer drug shows promise as treatment for Alzheimer's: in mice, medication clears plaque-forming protein.(STORY ONE)." Science news 181.5 (2012): 5-. Link to SFX for this item
8. Ghosh, Arun K. "Developing β-secretase inhibitors for treatment of Alzheimer's disease." Journal of neurochemistry 120.SUPPL. 1 (2012): 71-83. Link to Full Text for this item Link to SFX for this item
9. Meissburger, B. "Adipogenesis and insulin sensitivity in obesity are regulated by retinoid‐related orphan receptor gamma." EMBO molecular medicine 3.11 (2011): 637-651. Link to Full Text for this item Link to SFX for this item
10. Conejo Garcia, Ana a. "Conformational Dynamics of a Bispyridinium Cyclophane." Journal of organic chemistry 68.22 (2003): 8697-. Link to Full Text for this item Link to SFX for this item
11. Chernega, A. "The Chiral Auxiliary N-1-(1 '-Naphthyl)ethyl-O-tert-butylhydroxylamine: A Chiral Weinreb Amide Equivalent." Organic letters 11.15 (2009): 3254-3257. Link to Full Text for this item Link to SFX for this item
12. Vellas, B. ""Clinical trials in Alzheimer's disease": immunotherapy approaches." Journal of neurochemistry 120.SUPPL. 1 (2011): 186-193. Link to Full Text for this item Link to SFX for this item
13. Romero, A. "Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease." Bioorganic and medicinal chemistry letters 23.7 (2013): 1916-22. Link to SFX for this item
14. Wolfe, Michael S. "γ-Secretase inhibitors and modulators for Alzheimer's disease." Journal of neurochemistry 120.SUPPL. 1 (2011): 89-98. Link to Full Text for this item Link to SFX for this item
15. Davies, S. "On the Origins of Diastereoselectivity in the Alkylation of Enolates Derived from N-1-(1 '-Naphthyl)ethyl-O-tert-butylhydroxamates: Chiral Weinreb Amide Equivalents." Journal of organic chemistry 75.4 (2010): 1214-1227. Link to Full Text for this item Link to SFX for this item
16. Lelais, G. "Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants." Journal of medicinal chemistry 59.14 (2016): 6671-6689. Link to Full Text for this item Link to SFX for this item
17. Gege, C. "Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt." Bioorganic and medicinal chemistry letters 24.22 (2014): 5265-7. Link to SFX for this item
18. Chavez, F. "Sensing performance of palladium-functionalized WO3 nanowires by a drop-casting method." Applied surface science 275 (2013): 28-35. Link to SFX for this item
19. Laber Warren, E. "Early treatment for Alzheimer's.(World Changing Ideas)(trial for the experimental drug crenezumab)(Cover story)." Scientific American 307.6 (2012): 38-. Link to SFX for this item
20. Barrett, D2E20W2E W. "Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans." Neuroscience 230 (2012): 13-23. Link to SFX for this item
View More...
View Less...
Select All Clear All

Expand list of advanced services Advanced