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21 pages, 1104 KiB  
Article
The Short-Term Price Elasticity, Temperature Elasticity, and Wind Speed Elasticity of Electricity: A Case Study from Norway
by Johannes Idsø, Jon Gunnar Nesse and Øyvind Heimset Larsen
Sustainability 2024, 16(8), 3321; https://doi.org/10.3390/su16083321 (registering DOI) - 16 Apr 2024
Abstract
Energy production using hydropower has a 150-year history in Norway. High mountains, lots of rain, and a well-developed technology laid the foundation for low and stable electricity prices. The Norwegian electricity market is unique and different from any other country. Nearly all electricity [...] Read more.
Energy production using hydropower has a 150-year history in Norway. High mountains, lots of rain, and a well-developed technology laid the foundation for low and stable electricity prices. The Norwegian electricity market is unique and different from any other country. Nearly all electricity produced (98.3 percent) comes from renewable energy sources and 75 percent of the energy used for heating is electricity. From autumn 2020, major changes have been observed in the electricity market in Norway. In 2021, Norway opened two transmission cables, one to Germany and one to England. Both cables have a capacity of 1400 MW. The average price per MWh was NOK 263 in southern Norway in the period 2013–2020, which more than quadrupled to NOK 1192 per MWh in the period 2021–2023. We have investigated how the market reacted to the large price increase. We found that price elasticity is low even when the price is very high. It is the temperature that controls the consumption. When it is cold—below zero degrees Celcius—the temperature elasticity is close to zero; the temperature elasticity is not constant. When the temperature is above zero, the temperature elasticity is about −0.7. Price variations or changes in wind speed only lead to minor adjustments in electricity consumption. It is the variations in temperature that result in the observable fluctuations in electricity consumption. Since Norway exports electricity to Sweden, Denmark, Finland, Germany, the Netherlands, and England, knowledge of the Norwegian electricity market is relevant for many market participants. The Norwegian electricity market differs from those in other countries. Therefore, there is a risk that conclusions drawn about the Norwegian electricity market based on research conducted in other countries may be incorrect or inaccurate. Our contribution with this case study is to deepen the knowledge of how the electricity market in Norway operates. Full article
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16 pages, 1776 KiB  
Article
First Observations of Buzzards (Buteo) as Definitive Hosts of Sarcocystis Parasites Forming Cysts in the Brain Tissues of Rodents in Lithuania
by Petras Prakas, Marius Jasiulionis, Tautvilė Šukytė, Evelina Juozaitytė-Ngugu, Vitalijus Stirkė, Linas Balčiauskas and Dalius Butkauskas
Biology 2024, 13(4), 264; https://doi.org/10.3390/biology13040264 (registering DOI) - 16 Apr 2024
Abstract
Representatives of the genus Sarcocystis are worldwide distributed apicomplexan parasites characterised by two-host prey-predator relationships. Sarcocystis spp. produce sarcocysts in the muscles and brains of intermediate hosts and develop sporocysts in the intestines of definitive hosts. Two species, Sarcocystis glareoli and Sarcocystis microti [...] Read more.
Representatives of the genus Sarcocystis are worldwide distributed apicomplexan parasites characterised by two-host prey-predator relationships. Sarcocystis spp. produce sarcocysts in the muscles and brains of intermediate hosts and develop sporocysts in the intestines of definitive hosts. Two species, Sarcocystis glareoli and Sarcocystis microti, previously assigned to the genus Frenkelia, form cysts in the brains of rodents and are transmitted through the common buzzard (Buteo buteo). In our study, brain samples of 694 small mammals caught in different regions of Lithuania were examined for Sarcocystis spp. Additionally, 10 B. buteo and two rough-legged buzzards (Buteo lagopus) were tested for sporocysts of the analysed parasites. Sarcocystis species were identified based on 28S rRNA sequence comparison. Of the eleven species of small mammals tested, Sarcocystis parasites were observed only in the bank vole (Clethrionomys glareolus). Cysts of S. glareoli were detected in 34 out of 374 C. glareolus (9.1%, 95% CI = 6.4–12.5%). Molecular investigation showed the presence of only S. glareoli in the intestines of 50% of B. buteo. Furthermore, two species, Sarcocystis sp. Rod3 and Sarcocystis sp. Rod4, were confirmed in B. lagopus. Our results demonstrate the need for further studies on Sarcocystis cycling between rodents and birds. Full article
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18 pages, 7023 KiB  
Article
Physico-Chemical Properties of CdTe/Glutathione Quantum Dots Obtained by Microwave Irradiation for Use in Monoclonal Antibody and Biomarker Testing
by M. A. Ruiz-Robles, Francisco J. Solís-Pomar, Gabriela Travieso Aguilar, Maykel Márquez Mijares, Raine Garrido Arteaga, Olivia Martínez Armenteros, C. D. Gutiérrez-Lazos, Eduardo G. Pérez-Tijerina and Abel Fundora Cruz
Nanomaterials 2024, 14(8), 684; https://doi.org/10.3390/nano14080684 (registering DOI) - 16 Apr 2024
Abstract
In this report, we present the results on the physicochemical characterization of cadmium telluride quantum dots (QDs) stabilized with glutathione and prepared by optimizing the synthesis conditions. An excellent control of emissions and the composition of the nanocrystal surface for its potential application [...] Read more.
In this report, we present the results on the physicochemical characterization of cadmium telluride quantum dots (QDs) stabilized with glutathione and prepared by optimizing the synthesis conditions. An excellent control of emissions and the composition of the nanocrystal surface for its potential application in monoclonal antibody and biomarker testing was achieved. Two samples (QDYellow, QDOrange, corresponding to their emission colors) were analyzed by dynamic light scattering (DLS), and their hydrodynamic sizes were 6.7 nm and 19.4 nm, respectively. Optical characterization by UV-vis absorbance spectroscopy showed excitonic peaks at 517 nm and 554 nm. Photoluminescence spectroscopy indicated that the samples have a maximum intensity emission at 570 and 606 nm, respectively, within the visible range from yellow to orange. Infrared spectroscopy showed vibrational modes corresponding to the functional groups OH-C-H, C-N, C=C, C-O, C-OH, and COOH, which allows for the formation of functionalized QDs for the manufacture of biomarkers. In addition, the hydrodynamic radius, zeta potential, and approximate molecular weight were determined by dynamic light scattering (DLS), electrophoretic light scattering (ELS), and static light scattering (SLS) techniques. Size dispersion and the structure of nanoparticles was obtained by Transmission Electron Microscopy (TEM) and by X-ray diffraction. In the same way, we calculated the concentration of Cd2+ ions expressed in mg/L by using the Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-OES). In addition to the characterization of the nanoparticles, the labeling of murine myeloid cells was carried out with both samples of quantum dots, where it was demonstrated that quantum dots can diffuse into these cells and connect mostly with the cell nucleus. Full article
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25 pages, 13800 KiB  
Article
A Study on the Feasibility and Strategy of Developing Photovoltaic Integrated Shading Devices in Street Canyons
by Peng Wang, Wei Wang, Cheng Ji, Hongyu Zhi, Ling Jia, Chenglong Wang, Wendi Zhang and Lei Huang
Buildings 2024, 14(4), 1111; https://doi.org/10.3390/buildings14041111 (registering DOI) - 16 Apr 2024
Abstract
The measurement and analysis of the spatial attributes of the street canyon hold significant importance in the advancement of photovoltaic integrated shading devices (PVSDs). This study offers the space aspect ratio index AR(h) as a more efficient method for determining the optimal [...] Read more.
The measurement and analysis of the spatial attributes of the street canyon hold significant importance in the advancement of photovoltaic integrated shading devices (PVSDs). This study offers the space aspect ratio index AR(h) as a more efficient method for determining the optimal location for installing PVSDs on building facades in various street canyons. The AR(h) index addresses the limitations of the current quantitative index. This study examined the evolving regulations of indoor thermal conditions, natural lighting, and the performance of PVSDs in various street canyons. It assessed the viability of implementing PVSDs in different canyons and suggested development plans based on the variation law. The findings demonstrated that AR(h) is capable of effectively assessing and directing the implementation of PVSDs. When AR(h) is below 0.6, the shade of surrounding buildings has the least impact on the photovoltaic power output and building energy consumption in various street canyons. In this scenario, the building has the largest yearly energy-saving rate, making it highly ideal for implementing PVSDs on the building façade. In summary, the suitability of the AR(h) index in various street sceneries was assessed, offering valuable insights for the widespread implementation of PVSDs and street planning, thereby optimizing the utilization of solar energy. The findings of this study will be advantageous in diminishing the utilization of non-renewable energy sources in urban areas and mitigating carbon emissions to safeguard the environment. Full article
(This article belongs to the Special Issue Energy Optimization: Advanced Technologies Applied in Green Buildings)
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23 pages, 6439 KiB  
Review
Exploring the Ecological Implications, Gastronomic Applications, and Nutritional and Therapeutic Potential of Juglans regia L. (Green Walnut): A Comprehensive Review
by Shaikh Ayaz Mukarram, Sangram S. Wandhekar, Abdelhakam Esmaeil Mohamed Ahmed, Vinay Kumar Pandey, Oláh Csaba, Daróczi Lajos, Prokisch József, Endre Harsányi and Kovács Bela
Nutrients 2024, 16(8), 1183; https://doi.org/10.3390/nu16081183 (registering DOI) - 16 Apr 2024
Abstract
The green walnut, which is frequently overlooked in favor of its more mature sibling, is becoming a topic of great significance because of its unique ecological role, culinary flexibility, and therapeutic richness. The investigation of the bioactive substances found in green walnuts and [...] Read more.
The green walnut, which is frequently overlooked in favor of its more mature sibling, is becoming a topic of great significance because of its unique ecological role, culinary flexibility, and therapeutic richness. The investigation of the bioactive substances found in green walnuts and their possible effects on human health has therapeutic potential. Juglans regia L. is an important ecological component that affects soil health, biodiversity, and the overall ecological dynamic in habitats. Comprehending and recording these consequences are essential for environmental management and sustainable land-use strategies. Regarding cuisine, while black walnuts are frequently the main attraction, green walnuts have distinct tastes and textures that are used in a variety of dishes. Culinary innovation and the preservation of cultural food heritage depend on the understanding and exploration of these gastronomic characteristics. Omega-3 fatty acids, antioxidants, vitamins, and minerals are abundant in green walnuts, which have a comprehensive nutritional profile. Walnuts possess a wide range of pharmacological properties, including antioxidant, antibacterial, antiviral, anticancer, anti-inflammatory, and cognitive-function-enhancing properties. Consuming green walnuts as part of one’s diet helps with antioxidant defense, cardiovascular health, and general well-being. Juglans regia L., with its distinctive flavor and texture combination, is not only a delicious food but also supports sustainable nutrition practices. This review explores the nutritional and pharmacological properties of green walnuts, which can be further used for studies in various food and pharmaceutical applications. Full article
(This article belongs to the Special Issue Preventive and Therapeutic Nutraceuticals)
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11 pages, 651 KiB  
Article
Structural, Mechanical, and Optoelectronic Properties of CH3NH3PbI3 as a Photoactive Layer in Perovskite Solar Cell
by Elkana K. Rugut, Nnditshedzeni E. Maluta, Regina R. Maphanga, Refilwe E. Mapasha and Joseph K. Kirui
Photonics 2024, 11(4), 372; https://doi.org/10.3390/photonics11040372 (registering DOI) - 16 Apr 2024
Abstract
The structural, electronic, mechanical, and optical properties of pseudo-cubic CH3NH3PbI3 perovskite have been studied within the framework of density functional theory, in line with solar cell applications. The computed values of lattice and elastic constants concurred with the [...] Read more.
The structural, electronic, mechanical, and optical properties of pseudo-cubic CH3NH3PbI3 perovskite have been studied within the framework of density functional theory, in line with solar cell applications. The computed values of lattice and elastic constants concurred with the available theoretical and experimental data. This compound has a semi-conducting behavior, with a direct band gap of about 1.49 eV. Note that the solar radiation spectrum has a maximum energy intensity value of approximately 1.50 eV. Thus, semiconductors with such gaps are preferred for photovoltaic applications. Its elastic parameters reveal that it is a ductile material that is mechanically stable. Optical descriptors such as refractive index, reflectivity, extinction, energy loss, and absorption have been explored with the aim of establishing the optical features of the material. Our findings demonstrate that this perovskite is suitable for solar cell applications based on the size and nature of the band gap, as also supported by the obtained upper limit value of simulated power conversion efficiency via the spectroscopic limited maximum efficiency mathematical model. Full article
(This article belongs to the Section Optoelectronics and Optical Materials)
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23 pages, 5437 KiB  
Article
Temporal Complementarity Analysis of Wind and Solar Power Potential for Distributed Hybrid Electric Generation in Chile
by José Luis Muñoz-Pincheira, Lautaro Salazar, Felipe Sanhueza and Armin Lüer-Villagra
Energies 2024, 17(8), 1890; https://doi.org/10.3390/en17081890 (registering DOI) - 16 Apr 2024
Abstract
We evaluate the temporal complementarity in daily averages between wind and solar power potential in Chile using Spearman’s correlation coefficient. We used hourly wind speed and solar radiation data for 176 geographic points from 2004 to 2016. The results allow us to identify [...] Read more.
We evaluate the temporal complementarity in daily averages between wind and solar power potential in Chile using Spearman’s correlation coefficient. We used hourly wind speed and solar radiation data for 176 geographic points from 2004 to 2016. The results allow us to identify four zones: Zone A1 on the coast and in the valleys in the north of Chile between latitudes 18° S and 36° S, with moderate positive correlation; Zone A2 in the north Andes between latitudes 25° S and 33° S, with weak negative correlation; Zone B in the center-south part of the country between latitudes 36° S and 51° S with moderate negative correlation; and Zone C in the south, between latitudes 51° S and 55° S with null or weak positive correlation. On the one hand, the interannual analysis shows that Zone A1 keeps uniform correlation values with negative asymmetry, i.e., higher correlation values. On the other hand, there is positive asymmetry in most of the years in Zone A2, i.e., lower (or negative) values of correlation. Zone B shows an interannual oscillation of the median correlation, while Zone C shows a larger dispersion in the interannual results. Significance analysis shows that 163 out of the 176 points are statistically significant, while Zones A1, A2, and B have significant correlations, with Zone C being marginally significant. The results obtained are relevant information for further studies on the location of hybrid generation facilities. We expect our methodology to be instrumental in Chile’s energetic transition to a 100% renewable generation matrix. Full article
(This article belongs to the Section A: Sustainable Energy)
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12 pages, 1700 KiB  
Article
Characterization of CuAg Alloys with Low Ag Concentrations
by Lorenzo Mosesso, Salvatore Macis, Annalisa D’Arco, Augusto Marcelli, Andrea Notargiacomo, Marialilia Pea, Bruno Spataro, Vincenzo Stagno and Stefano Lupi
Materials 2024, 17(8), 1823; https://doi.org/10.3390/ma17081823 (registering DOI) - 16 Apr 2024
Abstract
Copper-based alloys designed to combine high electronic and thermal conductivities with high mechanical strength find a wide range of applications in different fields. Among the principal representatives, strongly diluted CuAg alloys are of particular interest as innovative materials for the realization of accelerating [...] Read more.
Copper-based alloys designed to combine high electronic and thermal conductivities with high mechanical strength find a wide range of applications in different fields. Among the principal representatives, strongly diluted CuAg alloys are of particular interest as innovative materials for the realization of accelerating structures when the use of high-gradient fields requires increasingly high mechanical and thermal performances to overcome the limitations induced by breakdown phenomena. This work reports the production and optical characterization of CuAg crystals at low Ag concentrations, from 0.028% wt to 0.1% wt, which guarantee solid solution hardening while preserving the exceptional conductivity of Cu. By means of Fourier Transform Infrared (FTIR) micro-spectroscopy experiments, the low-energy electrodynamics of the alloys are compared with that of pure Cu, highlighting the complete indistinguishability in terms of electronic transport for such low concentrations. The optical data are further supported by Raman micro-spectroscopy and SEM microscopy analyses, allowing the demonstration of the full homogeneity and complete solubility of solid Ag in copper at those concentrations. Together with the solid solution hardening deriving from the alloying process, these results support the advantage of strongly diluted CuAg alloys over conventional materials for their application in particle accelerators. Full article
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19 pages, 1705 KiB  
Article
An Insight into Knowledge, Perspective, and Practices of Indian Optometrists towards Childhood Myopia
by Archana Naik, Siddharth K. Karthikeyan, Jivitha Jyothi Ramesh, Shwetha Bhaskar, Chinnappa A. Ganapathi and Sayantan Biswas
Vision 2024, 8(2), 22; https://doi.org/10.3390/vision8020022 (registering DOI) - 16 Apr 2024
Abstract
The current understanding of clinical approaches and barriers in managing childhood myopia among Indian optometrists is limited. This research underscores the necessity and relevance of evidence-based practice guidelines by exploring their knowledge, attitude, and practice towards childhood myopia. A self-administered internet-based 26-item survey [...] Read more.
The current understanding of clinical approaches and barriers in managing childhood myopia among Indian optometrists is limited. This research underscores the necessity and relevance of evidence-based practice guidelines by exploring their knowledge, attitude, and practice towards childhood myopia. A self-administered internet-based 26-item survey was circulated online among practicing optometrists in India. The questions assessed the demographics, knowledge, self-reported clinical practice behavior, barriers, source of information guiding their management, and extent of adult caregiver engagement for childhood myopia. Of 393 responses, a significant proportion of respondents (32.6–92.4%) were unaware of the ocular complications associated with high myopia, with less than half (46.5%) routinely performing ocular biometry in clinical practice. Despite the growing awareness of emerging myopia management options, the uptake remains generally poor, with single-vision distance full-correction spectacles (70.3%) being the most common mode of vision correction. Barriers to adopting optimal myopia care are medicolegal concerns, absence of clinical practice guidelines, and inadequate consultation time. Own clinical experience and original research articles were the primary sources of information supporting clinical practice. Most (>70%) respondents considered involving the adult caregiver in their child’s clinical decision-making process. While practitioners’ awareness and activity of newer myopia management strategies are improving, there is plenty of scope for its enhancement. The importance of evidence-based practice guidelines and continuing education on myopia control might help practitioners enhance their clinical decision-making skills. Full article
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15 pages, 1122 KiB  
Review
Co-Transcriptional Regulation of HBV Replication: RNA Quality Also Matters
by Guillaume Giraud, Khadija El Achi, Fabien Zoulim and Barbara Testoni
Viruses 2024, 16(4), 615; https://doi.org/10.3390/v16040615 (registering DOI) - 16 Apr 2024
Abstract
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, or covalently closed [...] Read more.
Chronic hepatitis B (CHB) virus infection is a major public health burden and the leading cause of hepatocellular carcinoma. Despite the efficacy of current treatments, hepatitis B virus (HBV) cannot be fully eradicated due to the persistence of its minichromosome, or covalently closed circular DNA (cccDNA). The HBV community is investing large human and financial resources to develop new therapeutic strategies that either silence or ideally degrade cccDNA, to cure HBV completely or functionally. cccDNA transcription is considered to be the key step for HBV replication. Transcription not only influences the levels of viral RNA produced, but also directly impacts their quality, generating multiple variants. Growing evidence advocates for the role of the co-transcriptional regulation of HBV RNAs during CHB and viral replication, paving the way for the development of novel therapies targeting these processes. This review focuses on the mechanisms controlling the different co-transcriptional processes that HBV RNAs undergo, and their contribution to both viral replication and HBV-induced liver pathogenesis. Full article
(This article belongs to the Special Issue HBV Transcriptional and Post-transcriptional Regulation)
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19 pages, 11355 KiB  
Article
Advanced Prussian Blue Cathodes for Rechargeable Li-Ion Batteries
by Shun-Ji Wu, Wen-Hsien Li, Erdembayalag Batsaikhan, Ma-Hsuan Ma and Chun-Chuen Yang
Solids 2024, 5(2), 208-226; https://doi.org/10.3390/solids5020014 (registering DOI) - 16 Apr 2024
Abstract
Taking advantage of fact that the surface electrons of metallic nanoparticles (NPs) can be effectively released even at a low voltage bias, we demonstrate an improvement in the electrochemical performance of nanosized Prussian Blue (PB)-based secondary batteries through the incorporation of bare Ag [...] Read more.
Taking advantage of fact that the surface electrons of metallic nanoparticles (NPs) can be effectively released even at a low voltage bias, we demonstrate an improvement in the electrochemical performance of nanosized Prussian Blue (PB)-based secondary batteries through the incorporation of bare Ag or Ni NPs in the vicinity of the working PB NPs. It is found that the capacity for electrochemical energy storage of the 17 nm PB-based battery is significantly higher than the capacity of 10 nm PB-based, 35 nm PB-based or 46 nm PB-based batteries. There is a critical PB size for the highest electrochemical energy storage efficiency. The full specific capacity CF of the 17 nm PB-based battery stabilized to 62 mAh/g after 130 charge–discharge cycles at a working current of IW = 0.03 mA. The addition of 14 mass percent of Ag NPs in the vicinity of the PB NPs gave rise to a 32% increase in the stabilized CF. A 42% increase in the stabilized CF could be obtained with the addition of 14 mass percent of Ag NPs on the working electrode of the 35 nm PB-based battery. An enhancement in CF was also found for electrodes incorporating bare Ni NPs but the effect was smaller. Full article
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29 pages, 3853 KiB  
Review
Recent Advances in Magnetically Actuated Droplet Manipulation for Biomedical Applications
by Jiaqi Li, Kaixin Su, Hailan Liu and Yuan Zou
Magnetochemistry 2024, 10(4), 28; https://doi.org/10.3390/magnetochemistry10040028 (registering DOI) - 16 Apr 2024
Abstract
The manipulation of droplets plays a vital role in biomedicine, chemistry, and hydromechanics, especially in microfluidics. Magnetic droplet manipulation has emerged as a prominent and advanced technique in comparison to other modes such as dielectric infiltration, optical radiation, and surface acoustic waves. Its [...] Read more.
The manipulation of droplets plays a vital role in biomedicine, chemistry, and hydromechanics, especially in microfluidics. Magnetic droplet manipulation has emerged as a prominent and advanced technique in comparison to other modes such as dielectric infiltration, optical radiation, and surface acoustic waves. Its notable progress is attributed to several advantages, including excellent biocompatibility, remote and non-contact control, and instantaneous response. This review provides a comprehensive overview of recent developments in magnetic droplet manipulation and its applications within the biomedical field. Firstly, the discussion involves an examination of the distinctive features associated with droplet manipulation based on both permanent magnet and electromagnet principles, along with a thorough exploration of the influencing factors impacting magnetic droplet manipulation. Additionally, an in-depth review of magnetic actuation mechanisms and various droplet manipulation methods is presented. Furthermore, the article elucidates the biomedical applications of magnetic droplet manipulation, particularly its role in diagnostic assays, drug discovery, and cell culture. Finally, the highlights and challenges of magnetic droplet manipulation in biomedical applications are described in detail. Full article
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12 pages, 3313 KiB  
Article
GmMYB114 Facilitates the Synthesis of Anthocyanins in Soybean Sprouts under Blue Light
by Li Jia, Hong Xu, Xinxin Xu, Kai Gao, Keying Zhao, Jingran Dong and Nana Su
Plants 2024, 13(8), 1107; https://doi.org/10.3390/plants13081107 (registering DOI) - 16 Apr 2024
Abstract
Soybean sprouts constitute a significant segment of the vegetable market due to their nutritional richness, particularly in various flavonoids, which contribute to numerous health benefits. The augmentation of the flavonoid content in soybean sprouts is pivotal for enhancing their economic value. While research [...] Read more.
Soybean sprouts constitute a significant segment of the vegetable market due to their nutritional richness, particularly in various flavonoids, which contribute to numerous health benefits. The augmentation of the flavonoid content in soybean sprouts is pivotal for enhancing their economic value. While research has established the potential of blue light in promoting the synthesis of anthocyanins, a subclass of flavonoids known for their health advantages, the precise regulatory mechanisms remain elusive. In this study, we identified a notable upregulation of an R2R3 type MYB transcription factor, GmMYB114, in response to blue light exposure, exhibiting a significant positive correlation with anthocyanin accumulation in soybean sprouts. The functional role of GmMYB114 was validated in soybean hairy roots, wherein its overexpression substantially augmented anthocyanin synthesis. Further investigations employing yeast one-hybrid (Y1H), dual-luciferase reporter (LUC), and GUS assays revealed that GmMYB114 indirectly influences anthocyanin synthesis as it does not directly bind to the promoters of anthocyanin synthesis genes to activate their expression. These findings contribute to elucidating the mechanism underlying blue light-mediated enhancement of anthocyanin synthesis in soybean sprouts, offering valuable insights for harnessing molecular technologies to obtain anthocyanin-enriched soybean sprouts. Full article
(This article belongs to the Section Crop Physiology and Crop Production)
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14 pages, 5237 KiB  
Article
Comparing Accuracy of Wildfire Spread Prediction Models under Different Data Deficiency Conditions
by Jiahao Zhou, Wenyu Jiang, Fei Wang, Yuming Qiao and Qingxiang Meng
Fire 2024, 7(4), 141; https://doi.org/10.3390/fire7040141 (registering DOI) - 16 Apr 2024
Abstract
Wildfire is one of the most severe natural disasters globally, profoundly affecting natural ecology, economy, and health and safety. Precisely predicting the spread of wildfires has become an important research topic. Current fire spread prediction models depend on inputs from a variety of [...] Read more.
Wildfire is one of the most severe natural disasters globally, profoundly affecting natural ecology, economy, and health and safety. Precisely predicting the spread of wildfires has become an important research topic. Current fire spread prediction models depend on inputs from a variety of geographical and environmental variables. However, unlike the ideal conditions simulated in the laboratory, data gaps often occur in real wildfire scenarios, posing challenges to the accuracy and robustness of predictions. It is necessary to explore the extent to which different missing items affect prediction accuracy, thereby providing rational suggestions for emergency decision-making. In this paper, we tested how different conditions of missing data affect the prediction accuracy of existing wildfire spread models and quantified the corresponding errors. The final experimental results suggest that it is necessary to judge the potential impact of data gaps based on the geographical conditions of the study area appropriately, as there is no significant pattern of behavior yet identified. This study aims to simulate the impact of data scarcity on the accuracy of wildfire spread prediction models in real scenarios, thereby enabling researchers to better understand the priority of different environmental variables for the model and identify the acceptable degree of missing data and the indispensable data attributes. It offers new insights for developing spread prediction models applicable to real-world scenarios and rational assessment of the effectiveness of model outcomes. Full article
(This article belongs to the Special Issue Intelligent Fire Protection)
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20 pages, 7842 KiB  
Article
Enhancing the Electrochemical Performance of ZnO-Co3O4 and Zn-Co-O Supercapacitor Electrodes Due to the In Situ Electrochemical Etching Process and the Formation of Co3O4 Nanoparticles
by Khabibulla Abdullin, Maratbek Gabdullin, Zhanar Kalkozova, Vladislav Kudryashov, Mojtaba Mirzaeian, Kassym Yelemessov, Dinara Baskanbayeva and Abay Serikkanov
Energies 2024, 17(8), 1888; https://doi.org/10.3390/en17081888 (registering DOI) - 16 Apr 2024
Abstract
Zinc oxide (ZnO) and materials based on it are often used to create battery-type supercapacitor electrodes and are considered as promising materials for hybrid asymmetric supercapacitors. However, when creating such electrodes, it is necessary to take into account the instability and degradation of [...] Read more.
Zinc oxide (ZnO) and materials based on it are often used to create battery-type supercapacitor electrodes and are considered as promising materials for hybrid asymmetric supercapacitors. However, when creating such electrodes, it is necessary to take into account the instability and degradation of zinc oxide in aggressive environments with a non-neutral pH. To the best of our knowledge, studies of the changes in the properties of ZnO-containing electrodes in alkaline electrolytes have not been carried out. In this work, changes in the structure and properties of these electrodes under alkaline treatment were investigated using the example of ZnO-containing composites, which are often used for the manufacturing of supercapacitor electrodes. Supercapacitor electrodes made of two materials containing ZnO were studied: (i) a heterogeneous ZnO-Co3O4 system, and (ii) a hexagonal h-Zn-Co-O solid solution. A comparison was made between the structure and properties of these materials before and after in situ electrochemical oxidation in the process of measuring cyclic voltammetry and galvanostatic charge/discharge. It has been shown that the structure of both nanoparticles of the heterogeneous ZnO-Co3O4 system and the h-Zn-Co-O solid solution changes due to the dissolution of ZnO in the alkaline electrolyte 3.5 M KOH, with the short-term alkaline treatment producing cobalt and zinc hydroxides, and long-term exposure leading to electrochemical cyclic oxidation–reduction, forming cobalt oxide Co3O4. Since the resulting cobalt oxide nanoparticles are immobilized in the electrode structure, a considerable specific capacity of 446 F g−1 or 74.4 mA h g−1 is achieved at a mass loading of 0.0105 g. The fabricated hybrid capacitor showed a good electrochemical performance, with a series resistance of 0.2 Ohm and a capacitance retention of 87% after 10,000 cycles. Full article
(This article belongs to the Collection Batteries, Fuel Cells and Supercapacitors Technologies)
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15 pages, 2928 KiB  
Article
Cryo-Milled β-Glucan Nanoparticles for Oral Drug Delivery
by Guanyu Chen, Yi Liu, Darren Svirskis, Hongyu Li, Man Ying, Weiyue Lu and Jingyuan Wen
Pharmaceutics 2024, 16(4), 546; https://doi.org/10.3390/pharmaceutics16040546 (registering DOI) - 16 Apr 2024
Abstract
Gemcitabine is a nucleoside analog effective against a number of cancers. However, it has an oral bioavailability of less than 10%, due to its high hydrophilicity and low permeability through the intestinal epithelium. Therefore, the aim of this project was to develop a [...] Read more.
Gemcitabine is a nucleoside analog effective against a number of cancers. However, it has an oral bioavailability of less than 10%, due to its high hydrophilicity and low permeability through the intestinal epithelium. Therefore, the aim of this project was to develop a novel nanoparticulate drug delivery system for the oral delivery of gemcitabine to improve its oral bioavailability. In this study, gemcitabine-loaded β-glucan NPs were fabricated using a film-casting method followed by a freezer-milling technique. As a result, the NPs showed a small particle size of 447.6 ± 14.2 nm, and a high drug entrapment efficiency of 64.3 ± 2.1%. By encapsulating gemcitabine into β-glucan NPs, a sustained drug release profile was obtained, and the anomalous diffusion release mechanism was analyzed, indicating that the drug release was governed by diffusion through the NP matrix as well as matrix erosion. The drug-loaded NPs had a greater ex vivo drug permeation through the porcine intestinal epithelial membrane compared to the plain drug solution. Cytotoxicity studies showed a safety profile of the β-glucan polymers, and the IC50s of drug solution and drug-loaded β-glucan NPs were calculated as 228.8 ± 31.2 ng·mL−1 and 306.1 ± 46.3 ng·mL−1, respectively. Additionally, the LD50 of BALB/c nude mice was determined as 204.17 mg/kg in the acute toxicity studies. Notably, pharmacokinetic studies showed that drug-loaded β-glucan NPs could achieve a 7.4-fold longer T1/2 and a 5.1-fold increase in oral bioavailability compared with plain drug solution. Finally, in vivo pharmacodynamic studies showed the promising capability of gemcitabine-loaded β-glucan NPs to inhibit the 4T1 breast tumor growth, with a 3.04- and 1.74-fold reduction compared to the untreated control and drug solution groups, respectively. In conclusion, the presented freezer-milled β-glucan NP system is a suitable drug delivery method for the oral delivery of gemcitabine and demonstrates a promising potential platform for oral chemotherapy. Full article
(This article belongs to the Special Issue Advances in Oral Administration)
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16 pages, 29694 KiB  
Article
Histopathological Lesions Caused by a Digenean Trematode in a Pest Apple Snail, Pomacea canaliculata, in Its Native Geographic Distribution Area
by Lorena Evangelina Martinez, Carmen Gilardoni, Cintia Débora Medina, Florencia Cremonte and Jorge Alejandro Etchegoin
Animals 2024, 14(8), 1191; https://doi.org/10.3390/ani14081191 (registering DOI) - 16 Apr 2024
Abstract
Pomacea canaliculata is one of the most dangerous invasive species. Morphological and molecular analyses have revealed that a digenean species belonging to the family Echinostomatidae parasitizes this snail at two sites in Buenos Aires Province, Argentina, South America. Molecular results confirmed that the [...] Read more.
Pomacea canaliculata is one of the most dangerous invasive species. Morphological and molecular analyses have revealed that a digenean species belonging to the family Echinostomatidae parasitizes this snail at two sites in Buenos Aires Province, Argentina, South America. Molecular results confirmed that the species belongs to a genus closely related to Patagifer. Analysis of the 28S rRNA showed that the sequences of the rediae and metacercariae are identical, indicating that the apple snail acts as the first and second intermediate host. The cercariae may encyst as metacercaria inside the redia and also emerge and re-infect the same snail or another snail. The prevalence of digeneans was higher in one of the sampling locations (15.1% vs. 0.72%), probably because the bird species that acts as the definitive host is more abundant in that area. Histopathological examination showed that the parasite quickly invades multiple host organs (gills, intestines, albumen gland, lung, kidney, and mantle border) besides the gonad and digestive gland, as is usual in digeneans. In addition, the partial or total castration of snails was observed in cases of moderate and high infection intensity. In males, there was loss of integrity in testicular tubules, while in females, the replacement of ovarian tissue by rediae was found. Full article
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14 pages, 3236 KiB  
Article
Inclusiveness of Public Space: Experimental Approaches for the Revitalisation of Smaller Historic Urban Centres
by Antonella Mamì
Sustainability 2024, 16(8), 3320; https://doi.org/10.3390/su16083320 (registering DOI) - 16 Apr 2024
Abstract
In recent decades, many small Italian historic centers—particularly those situated inland—have witnessed a population decline due to inadequate access to public services and facilities. However, this depopulation has also allowed many centers to retain their distinctive features, now conferring upon them great cultural–historical [...] Read more.
In recent decades, many small Italian historic centers—particularly those situated inland—have witnessed a population decline due to inadequate access to public services and facilities. However, this depopulation has also allowed many centers to retain their distinctive features, now conferring upon them great cultural–historical and landscape value. New quality-of-life-centered economic models present the development of accessible public services as a necessity. Such a process could catalyze the recovery and growth of these centers, which continue to be deserted, regardless of their value. This paper considers combined solutions, including sustainable mobility, digital accessibility, networked services, and technological devices by applying them to trans-scalar studies with the goal of achieving sustainable outcomes. Some of the proposed solutions are the resolution of irregular ground levels, the use of electric vehicles, the creation of sharing models, the physical overhaul of routes, and the retrofitting of minor buildings for inclusive use in a comprehensive human-centered approach toward regeneration. This study is in line with the European guidelines for sustainable and intelligent mobility, whose goal is for at least one hundred European cities to become accessible to all and shifted to zero-emission mobility. Here, sustainable and smart mobility is understood not only as an improvement of environmental and social conditions, but also as a catalyst for environmental and social improvements and as an opportunity to enhance the livability of smaller, geographically isolated historic centers, moving toward a new economy of urban reclamation. Full article
(This article belongs to the Special Issue Sustainability in Architecture and Engineering)
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15 pages, 3467 KiB  
Article
Extracellular Vesicles-Mediated Bio-Orthogonal Catalysis in Growing Tumors
by Maria Sancho-Albero, Victor Sebastian, Ana M. Perez-Lopez, Pilar Martin-Duque, Asier Unciti-Broceta and Jesus Santamaria
Cells 2024, 13(8), 691; https://doi.org/10.3390/cells13080691 (registering DOI) - 16 Apr 2024
Abstract
Several studies have reported the successful use of bio-orthogonal catalyst nanoparticles (NPs) for cancer therapy. However, the delivery of the catalysts to the target tissues in vivo remains an unsolved challenge. The combination of catalytic NPs with extracellular vesicles (EVs) has been proposed [...] Read more.
Several studies have reported the successful use of bio-orthogonal catalyst nanoparticles (NPs) for cancer therapy. However, the delivery of the catalysts to the target tissues in vivo remains an unsolved challenge. The combination of catalytic NPs with extracellular vesicles (EVs) has been proposed as a promising approach to improve the delivery of therapeutic nanomaterials to the desired organs. In this study, we have developed a nanoscale bio-hybrid vector using a CO-mediated reduction at low temperature to generate ultrathin catalytic Pd nanosheets (PdNSs) as catalysts directly inside cancer-derived EVs. We have also compared their biodistribution with that of PEGylated PdNSs delivered by the EPR effect. Our results indicate that the accumulation of PdNSs in the tumour tissue was significantly higher when they were administered within the EVs compared to the PEGylated PdNSs. Conversely, the amount of Pd found in non-target organs (i.e., liver) was lowered. Once the Pd-based catalytic EVs were accumulated in the tumours, they enabled the activation of a paclitaxel prodrug demonstrating their ability to carry out bio-orthogonal uncaging chemistries in vivo for cancer therapy. Full article
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18 pages, 3429 KiB  
Article
Low-Temperature Deposition of Diamond Films by MPCVD with Graphite Paste Additive
by Stephen Yang-En Guu, Fu-Cheng Lin, Yu-Sen Chien, Alen Jhang and Yon-Hua Tzeng
C 2024, 10(2), 39; https://doi.org/10.3390/c10020039 (registering DOI) - 16 Apr 2024
Abstract
Modern integrated circuits (ICs) take advantage of three-dimensional (3D) nanostructures in devices and interconnects to achieve high-speed and ultra-low-power performance. The choice of electrical insulation materials with excellent dielectric strength, electrical resistivity, strong mechanical strength, and high thermal conductivity becomes critical. Diamond possesses [...] Read more.
Modern integrated circuits (ICs) take advantage of three-dimensional (3D) nanostructures in devices and interconnects to achieve high-speed and ultra-low-power performance. The choice of electrical insulation materials with excellent dielectric strength, electrical resistivity, strong mechanical strength, and high thermal conductivity becomes critical. Diamond possesses these properties and is recently recognized as a promising dielectric material for the fabrication of advanced ICs, which are sensitive to detrimental high-temperature processes. Therefore, a high-rate low-temperature deposition technique for large-grain, high-quality diamond films of the thickness of a few tens to a few hundred nanometers is desirable. The diamond growth rate by microwave plasma chemical vapor deposition (MPCVD) decreases rapidly with lowering substrate temperature. In addition, the thermal conductivity of non-diamond carbon is much lower than that of diamond. Furthermore, a small-grain diamond film suffers from poor thermal conductivity due to frequent phonon scattering at grain boundaries. This paper reports a novel MPCVD process aiming at high growth rate, large grain size, and high sp3/sp2 ratio for diamond films deposited on silicon. Graphite paste containing nanoscale graphite and oxy-hydrocarbon binder and solvent vaporizes and mixes with gas feeds of hydrogen, methane, and carbon dioxide to form plasma. Rapid diamond growth of diamond seeds at 450 °C by the plasma results in large-grained diamond films on silicon at a high deposition rate of 200 nm/h. Full article
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13 pages, 838 KiB  
Article
Early Neurophysiological Abnormalities in Suspected Acute Canine Polyradiculoneuropathy
by Laura Porcarelli, Alberto Cauduro, Ezio Bianchi, Claudia Pauciulo, Chiara Maurelli and Daniele Corlazzoli
Vet. Sci. 2024, 11(4), 178; https://doi.org/10.3390/vetsci11040178 (registering DOI) - 16 Apr 2024
Abstract
Acute canine polyradiculoneuritis (ACP) is a common peripheral neuropathy in dogs, and is generally self-limiting and benign. Electrodiagnostic (EDX) tests are typically performed after 7–10 days. Delaying the definitive diagnosis may hamper the treatment of other causes of acute weakness, which may require [...] Read more.
Acute canine polyradiculoneuritis (ACP) is a common peripheral neuropathy in dogs, and is generally self-limiting and benign. Electrodiagnostic (EDX) tests are typically performed after 7–10 days. Delaying the definitive diagnosis may hamper the treatment of other causes of acute weakness, which may require specific treatments and may carry different prognoses. This retrospective multicenter study aims to assess whether EDX performed within the first 6 days of clinical signs onset can detect alterations indicative of ACP, and aims to characterize the most prevalent alterations. A total of 71 dogs with suspected ACP were retrospectively analyzed and classified into two groups based on EDX timing: early group (EG, 1–6 days after symptom onset) and late group (LG, 7–15 days after symptom onset). In our study, no significant differences were found between the two groups in motor nerve conduction studies (MNCSs) and F-wave analysis, indicating that EDX is able to demonstrate abnormalities even in the first 6 days from onset. Although the LG showed significantly greater degrees of electromyographic (EMG) alterations compared to the EG, frequent muscle alterations were still observed in the EG group. These findings support the use of EDX in patients with suspected ACP within the first 6 days from the clinical onset. Prompt neurophysiological examinations for suspected ACP patients can be performed effectively and can help allow for early diagnosis and facilitate appropriate treatment. Full article
(This article belongs to the Special Issue Neurology and Neurosurgery in Small Animals)
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24 pages, 75890 KiB  
Article
Coseismic and Early Postseismic Deformation Mechanism Following the 2021 Mw 7.4 Maduo Earthquake: Insights from Satellite Radar Interferometry and GPS
by Chuanzeng Shu, Zhiguo Meng, Qiong Wu, Wei Xiong, Lijia He, Xiaoping Zhang and Dan Xu
Remote Sens. 2024, 16(8), 1399; https://doi.org/10.3390/rs16081399 (registering DOI) - 16 Apr 2024
Abstract
Exploring the deformation mechanism of the 2021 Mw 7.4 Maduo Earthquake is crucial for better understanding the seismic hazard of the faults with low strain rates inside the Bayan Har block. This study leverages deformation information derived from Sentient-1 A/B images and GPS [...] Read more.
Exploring the deformation mechanism of the 2021 Mw 7.4 Maduo Earthquake is crucial for better understanding the seismic hazard of the faults with low strain rates inside the Bayan Har block. This study leverages deformation information derived from Sentient-1 A/B images and GPS data to investigate in detail the co- and postseismic deformation mechanisms using multiple methods. The main results are as follows. First, the postseismic InSAR time series robustly identified the reactivation of the Changmahe fault, indicating the impact of the Maduo event on surrounding active faults. Second, the joint inversion of Interferometric Synthetic Aperture Radar and GPS revealed that (1) there was a complementary and partially overlapping relationship between the coseismic slip and postseismic afterslip of the main rupture; and (2) the Changmahe fault exhibited thrust compression dislocation in the early stage and experienced a sustained compressive effect from afterslip in the one year after the mainshock. Third, modeling the processes of viscoelastic relaxation and poroelastic rebound revealed that the postseismic deformation was probably caused by a combination of afterslip (near-field) and viscoelastic relaxation (near and far field). Fourth, the stress changes driven by the Maduo event revealed that the seismic gaps inside the Maqin-Maqu segment and the Kunlun Pass-Jiangcuo fault will be potential seismic risks in the future. Full article
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19 pages, 9628 KiB  
Article
Sponge Communities of Submarine Caves and Tunnels on the Fernando de Noronha Archipelago, Northeast Brazil
by Guilherme Muricy, Anaíra Lage, Joana Sandes, Michelle Klautau, Ulisses Pinheiro, Marinella Silva Laport, Bruno Francesco Rodrigues de Oliveira, Carolline Braga Pequeno and Matheus Vieira Lopes
J. Mar. Sci. Eng. 2024, 12(4), 657; https://doi.org/10.3390/jmse12040657 (registering DOI) - 16 Apr 2024
Abstract
Submarine caves are important biodiversity reservoirs, but there is little information about the biota of marine caves in the Southwestern Atlantic. Here, we describe three submarine cavities and their sponge communities on the Fernando de Noronha Archipelago, Northeast Brazil. The underwater cavities were [...] Read more.
Submarine caves are important biodiversity reservoirs, but there is little information about the biota of marine caves in the Southwestern Atlantic. Here, we describe three submarine cavities and their sponge communities on the Fernando de Noronha Archipelago, Northeast Brazil. The underwater cavities were explored and collections were made through scuba diving from 5 to 18 m depths. Sapata Cave has a wide semi-dark zone near the entrance, a narrow transition zone, and a dark chimney, which is closed at the top. Ilha do Meio Cave is narrower and shallower than Sapata Cave, but has a long passage that leads to two completely dark rooms. Pedras Secas Tunnel has only a semi-dark zone with high water movement. The sponge communities in the semi-dark zones of the three cavities are rich and dominated by the classes Demospongiae and Homoscleromorpha, but Calcarea are also common. The transition zones of both caves are dominated by a desma-bearing sponge, thinly encrusting spirastrellids, and small Homoscleromopha and Calcarea. The dark zone in Ilha do Meio Cave is almost azoic, with only three species. This study has increased the number of sponge species known in submarine cavities on Fernando de Noronha from 29 to 69, highlighting the great richness of the sponge communities in these cryptic environments. Full article
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