Selenium (Se) is a micronutrient known for its essential role in human health and plant metabolism. Waxy maize (Zea mays L. sinensis kulesh)—known for its high nutritional quality and distinctive flavor—holds significant consumer appeal. Therefore, this study aims to assess the effects of foliar Se spraying on the nutritional quality of waxy maize grains, with a focus on identifying varietal differences and determining optimal Se dosage levels for maximizing nutritional benefits. We employed a two-factor split-plot design to assess the nutritional quality, trace elements, and pigment content of jinnuo20 (J20) and caitiannuo1965 (C1965) at the milk stage after being subjected to varying Se doses sprayed on five leaves. Our findings indicate superior nutrient content in J20 compared to C1965, with both varieties exhibiting optimal quality under Se3 treatment, falling within the safe range of Se-enriched agricultural products. JS3 (0.793) demonstrated the highest overall quality, followed by JS2 (0.606), JS4 (0.411), and JS1 (0.265), while CS0 had the lowest (−0.894). These results underscore the potential of foliar biofortification to enhance the functional component contents of waxy maize grains. Full article

Multiple sclerosis (MS) arises from a complex interplay between host genetic factors and environmental components, with the gut microbiota emerging as a key area of investigation. In the current study, we used ion torrent sequencing to delve into the bacteriome (bacterial microbiota) and mycobiome (fungal microbiota) of people with MS (pwMS), and compared them to healthy controls (HC). Through principal coordinate, diversity, and abundance analyses, as well as clustering and cross-kingdom microbial correlation assessments, we uncovered significant differences in the microbial profiles between pwMS and HC. Elevated levels of the fungus Torulaspora and the bacterial family Enterobacteriaceae were observed in pwMS, whereas beneficial bacterial taxa, such as Prevotelladaceae and Dialister, were reduced. Notably, clustering analysis revealed overlapping patterns in the bacteriome and mycobiome data for 74% of the participants, with weakened cross-kingdom interactions evident in the altered microbiota of pwMS. Our findings highlight the dysbiosis of both bacterial and fungal microbiota in MS, characterized by shifts in biodiversity and composition. Furthermore, the distinct disease-associated pattern of fungi–bacteria interactions suggests that fungi, in addition to bacteria, contribute to the pathogenesis of MS. Overall, our study sheds light on the intricate microbial dynamics underlying MS, paving the way for further investigation into the potential therapeutic targeting of the gut microbiota in MS management. Full article

Age-related macular degeneration (AMD) is the most frequent cause of blindness in developed countries. The replacement of dysfunctional human retinal pigment epithelium (hRPE) cells by the transplantation of in vitro-cultivated hRPE cells to the affected area emerges as a feasible strategy for regenerative therapy. Synthetic biomimetic membranes arise as powerful hRPE cell carriers, but as biodegradability is a requirement, it also poses a challenge due to its limited durability. hRPE cells exhibit several characteristics that putatively respond to the type of membrane carrier, and they can be used as biomarkers to evaluate and further optimize such membranes. Here, we analyze the pigmentation, transepithelial resistance, genome integrity, and maturation markers of hRPE cells plated on commercial polycarbonate (PC) versus in-house electrospun polylactide-based (PLA) membranes, both enabling separate apical/basolateral compartments. Our results show that PLA is superior to PC-based membranes for the cultivation of hRPEs, and the BEST1/RPE65 maturation markers emerge as the best biomarkers for addressing the quality of hRPE cultivated in vitro. The stability of the cultures was observed to be affected by PLA aging, which is an effect that could be partially palliated by the coating of the PLA membranes. Full article

This research presents an experimental electric vehicle developed at the Tecnológico Nacional de México Celaya campus. It was decided to use a golf cart-type gasoline vehicle as a starting point. Initially, the body was removed, and the vehicle was electrified, meaning its engine was replaced with an electric one. Subsequently, sensors used to measure the vehicle states were placed, calibrated, and instrumented. Additionally, a mathematical model was developed along with a strategy for the parametric identification of this model. A communication scheme was implemented consisting of four slave devices responsible for controlling the accelerator, brake, steering wheel, and measuring the sensors related to odometry. The master device is responsible for communicating with the slaves, displaying information on a screen, creating a log, and implementing trajectory tracking techniques based on classical, geometric, and predictive control. Finally, the performance of the control algorithms implemented on the experimental prototype was compared in terms of tracking error and control input across three different types of trajectories: lane change, right-angle curve, and U-turn. Full article

Northern and southern fog events are identified over eastern China across 40 winters from 1981 to 2021. By performing composite analysis on these events, this study reveals that the formation of fog events is controlled by both dynamic and thermodynamic processes. The fog events were induced by Rossby wave trains over the Eurasian continent, leading to the development of surface wind and pressure anomalies, which favor the formation of fog events. The Rossby wave trains in northern and southern fog events are characterized by their occurrence in northern and southern locations, respectively, with different strengths. The water vapor fluxes that contribute to the enhancement of the northern fog events originate from the Yellow Sea and the East China Sea, whereas the southern fog events are characterized by water vapor from the East China Sea and the South China Sea. In both northern and southern fog events, dew point depression and positive A and K index anomalies are found in northern and southern regions of eastern China, which are indicative of supersaturated air and the unstable atmospheric saturation from the low to the middle troposphere, thus providing favorable conditions for the establishment of fog events in northern and southern regions of eastern China. Full article

Gas turbines are widely used as important equipment for electricity generation on islands and offshore platforms. During the operation of a gas turbine, the flame shape in the combustion chamber undergoes variations in response to changes in parameters such as gas turbine load, fuel distribution, and burner structure. These alterations in flame shape exert influence on combustion instability, emissions, and load characteristics. This study explores the variations in flame transition, emissions, and operating parameters among three distinct center stage structures: namely, the non-premix center stage (NPCS), premix center stage (PCS), and enhanced premix center stage (PCSE). The investigation is conducted using a heavy-duty gas turbine hybrid burner on a full temperature, full pressure, and full-size single burner experimental bench. Simultaneously, a multi-parameter numerical simulation regarding the influence of the central fuel split on flame shape analysis was conducted using the PCS burner under the design point for a more in-depth understanding of the mechanisms and for influencing factors associated with flame transition. The findings indicate that variations in flame transition loads among different central stage structures: for the NPCS burner, the transition occurs between 45% and 50% load; for the PCS burners, it takes place between 60% and 65% load; for the PCSE burners, it shifts between 55% and 60% load. Additionally, a reduction in NO_x emissions is observed during the flame transition process. Furthermore, it was found that decreasing the central stage fuel results in a decline in flame angle for the same burner structure. As the central stage fuel diminishes to a specific value, the flame shape undergoes a sudden change. Further reduction in central stage fuel does not significantly affect the flame shape and temperature distribution. Full article

As the need for handling complex geometries in computational fluid dynamics (CFD) grows, efficient and accurate mesh generation techniques become paramount. This study presents an adaptive mesh refinement (AMR) technology based on cell-based Cartesian grids, employing a distance-weighted least squares interpolation for finite difference discretization and utilizing immersed boundary methods for wall boundaries. This facilitates effective management of both transient and steady flow problems. Validation through supersonic flow over a forward-facing step, subsonic flow around a high Reynolds number NHLP airfoil, and supersonic flow past a sphere demonstrated AMR’s efficacy in capturing essential flow characteristics while wisely refining and coarsening meshes, thus optimizing resource utilization without compromising accuracy. Importantly, AMR simplified the capture of complex flows, obviating manual mesh densification and significantly improving the efficiency and reliability of CFD simulations. Full article

In this study, based on the Iwan model, the connection interface of the bolted joint structure subjected to lateral loads was simulated and comparatively analyzed. Commercial finite element software was used to model the bolted joint structure. Monotonic lateral loads and cyclic displacement loads were applied to the model. The changes in the preload force of the bolted connection structure, as well as the changes in the sticking zone and stress state of the connection interface, were analyzed, and the loading results of monotonic load and cyclic displacement load were compared. The results show that the contact interface stress decreases with the increase in displacement load, and this increase is also a nonlinear relationship, which is approximately in phase with the trend of the contact surface slip curve. The amount of contact surface stress loss and the amount of preload loss are not directly related to the magnitude of the initial preload, regardless of the loading conditions. The contact surface is also circular under any form of displacement loading, whether it is stressed or slipped. The amount of preload loss is proportional to the amount of bolt compression for that variable. Full article

This study assesses the usability of natural materials available in Australia’s remote communities for making fibre-reinforced mudbricks. The present construction cost for housing in remote areas is too high to maintain the level of housing required for the remote Australian population. As this includes mostly First Nations communities, more culturally appropriate housing materials and construction methods are being considered. This study looks at mudbricks made from laterite soil reinforced by spinifex fibre, both available in abundance in remote communities. Hence, this material is more acceptable to communities as it is more sustainable, and the construction methods are more suited for First Nations engagement. Various mixes were tested for compressive strength and erosion resistance. Results suggest that spinifex can significantly improve compressive strength and reduce erosion effects; however, spinifex showed adverse effects at the early stage of the spray test. The results satisfy the minimum strength and erosion resistance requirements for construction and suggest that spinifex-reinforced mudbricks could potentially be considered as an alternative material in remote housing. Full article

The digital age provides greater possibilities for quantitative research on rural tourism. This article examines Jilin Province as a case and analyzes the interannual, monthly, and holiday characteristics of rural tourism heat using big data. Using A-level rural tourism operating units as research samples, a mathematical model is constructed to evaluate the rural tourism heat from 2016 to 2021. Through a trend surface analysis and kernel density analysis, the spatiotemporal differentiation characteristics are explored; additionally, the spatial evolution law of the rural tourism hot and cold pattern is analyzed using counties as units. The research results show the following: (1) As an important component of the Jilin tourism industry, temporally, rural tourism has an overall trend of increasing popularity, with clear seasonal and holiday distribution patterns. Simultaneously, the periodic sporadic occurrence of the COVID-19 epidemic caused an obvious vulnerability in rural tourism fever. (2) Spatially, the structure of rural tourism shows an evolutionary process of “single core → multi core” and a diffusion trend of “central → eastern” and “central → western”. (3) Regarding the influencing factors, transportation conditions and resource endowments are dominant, and the impact of the economic development level is gradually weakening, while the impact of the ecological environment and industrial foundation is gradually increasing. Full article

This paper proposes a novel methodology to improve stability in a transmission system under critical conditions of operation when additional loads that take the system to the verge of stability are placed in weak bus bars according to the fast voltage stability index (FVSI). This paper employs the Newton–Raphson method to calculate power flows accurately and, based on that information, correctly calculate the FVSI for every transmission line. First, the weakest transmission line is identified by considering $N-1$ contingencies for the disconnection of transmission lines, and then all weak nodes associated with this transmission line are identified. Following this, critical scenarios generated by stochastically placed loads that will take the system to the verge of instability will be placed on the identified weak nodes. Then, the methodology will optimally size and place a single static VAR compensator SVC in the system to take the transmission system to the conditions before the additional loads are connected. Finally, the methodology will be validated by testing the system for critical contingencies when any transmission line associated with the weak nodes is disconnected. As a result, this paper’s methodology found a single SVC that will improve the system’s stability and voltage profiles to similar values when the additional loads are not connected and even before contingencies occur. The methodology is validated on three transmission systems: IEEE 14, 30, and 118 bus bars. Full article

Background: Both cognitive decline and unhealthy lifestyles have been linked to an elevated risk of mortality in older people. We aimed to investigate whether a healthy lifestyle might modify the association between cognitive function and all-cause mortality in Chinese older populations. Methods: The final analysis included 5124 individuals free of dementia, selected from the Chinese Longitudinal Healthy Longevity Survey from 2011 to 2018. Cognitive function was assessed in 2011 using the Mini-Mental State Examination (MMSE). A lifestyle score was calculated based on five lifestyle factors, including smoking, alcohol consumption, physical activity, diet, and body mass index. Cox proportional hazards models were performed to evaluate the association between baseline cognitive function and the risk of all-cause mortality, with an interaction term of cognitive function and lifestyle score being added to the models. Results: The average age of participants was 81.87 years old at baseline. During a median follow-up of 6.4 years, 1461 deaths were documented. Both higher cognitive function (HR: 0.96; 95% CI: 0.96–0.97) and a healthier lifestyle (HR: 0.92; 95% CI: 0.87–0.97) were significantly associated with a reduced risk of mortality. We found that lifestyle significantly modified the association of cognitive function with mortality (p for interaction = 0.004). The inverse relation between cognitive function and mortality was found to be more pronounced among participants with a healthier lifestyle. Of note, among the lifestyle scores component, diet showed a significant interaction with mortality (p for interaction = 0.003), and the protective HR of the all-cause mortality associated with higher MMSE scores was more prominent among participants with healthy diets compared with unhealthy diets. Conclusions: Our study indicates that cognitive decline is associated with a higher risk of mortality, and such associations are attenuated by maintaining a healthy lifestyle, with a particular emphasis on healthy diet. Full article

Cardiovascular diseases represent the leading cause of death in the world and are subject to limitations in prevention strategies despite the use of very effective drugs. The concept of residual risk (RR) is intrinsically related to that of global risk of which it represents a very significant percentage. In the cardiovascular field, the term RR refers to the probability of incurring a major cardiovascular event, despite adequate control of the risk factors present in the individual patient. A significant portion of the RR in the cardiovascular field results from the underestimation of additional risk factors not subjected to adequate intervention such as, for example, triglyceride levels in patients treated for the presence of hypertension and/or hypercholesterolemia. The control of the RR therefore appears as an essential condition for the effective reduction of the global risk profile and is based on an integrated intervention that combines all the different prevention strategies derived from the available evidence and capable of interacting on the basis of a strengthening reciprocal between lifestyle and pharmacological and nutraceutical intervention methods. Full article

The aim of this work was to investigate the influence of two locations and seven cultivars on the profiling of metabolites in organically grown plums (Prunus domestica L.) fruit in Norway. P, K, and Ca were most abundant in the studied fruits, while Ba and Sr formed a clear line between the locations. The most abundant sugars were glucose, fructose, sucrose, and sorbitol, which together accounted for up to 97.00%. Quinic acid and malic acid were the predominant organic acids, while chlorogenic acid, rutin, and kaempferol-3-O-glucoside were the most abundant polyphenols. Plums from Ullensvang were characterized by a higher content of minerals, sugars, organic acids, total polyphenol content (TPC), and radical scavenging activity (RSA), while plums from Telemark had a higher content of quantified polyphenols. The cultivar ‘Mallard’ had the highest mineral and radical scavenging activity, ‘Opal’ had the sweetest fruit, ‘Jubileum’ had the highest acidity, ‘Excalibur’ had the highest TPC content, and ‘Valor’ stored the highest content of quantified polyphenols, especially chlorogenic acid. These results provide comprehensive information on the chemical profiles of selected plum cultivars, suggesting that organic plums are a rich source of beneficial compounds that can have a positive impact on human health. Full article

Chickens are a major source of meat and eggs in human food and have significant economic value. Cadmium (Cd) is a common environmental pollutant that can contaminate feed and drinking water, leading to kidney injury in livestock and poultry, primarily by inducing the generation of free radicals. It is necessary to develop potential medicines to prevent and treat Cd-induced nephrotoxicity in poultry. Luteolin (Lut) is a natural flavonoid compound mainly extracted from peanut shells and has a variety of biological functions to defend against oxidative damage. In this study, we aimed to demonstrate whether Lut can alleviate kidney injury under Cd exposure and elucidate the underlying molecular mechanisms. Renal histopathology and cell morphology were observed. The indicators of renal function, oxidative stress, DNA damage and repair, NAD⁺ content, SIRT1 activity, and autophagy were analyzed. In vitro data showed that Cd exposure increased ROS levels and induced oxidative DNA damage and repair, as indicated by increased 8-OHdG content, increased $\mathsf{\gamma }$-H2AX protein expression, and the over-activation of the DNA repair enzyme PARP-1. Cd exposure decreased NAD⁺ content and SIRT1 activity and increased LC3 II, ATG5, and particularly p62 protein expression. In addition, Cd-induced oxidative DNA damage resulted in PARP-1 over-activation, reduced SIRT1 activity, and autophagic flux blockade, as evidenced by reactive oxygen species scavenger NAC application. The inhibition of PARP-1 activation with the pharmacological inhibitor PJ34 restored NAD⁺ content and SIRT1 activity. The activation of SIRT1 with the pharmacological activator RSV reversed Cd-induced autophagic flux blockade and cell injury. In vivo data demonstrated that Cd treatment caused the microstructural disruption of renal tissues, reduced creatinine, and urea nitrogen clearance, raised MDA content, and decreased the activities or contents of antioxidants (GSH, T-SOD, CAT, and T-AOC). Cd treatment caused oxidative DNA damage and PARP-1 activation, decreased NAD⁺ content, decreased SIRT1 activity, and impaired autophagic flux. Notably, the dietary Lut supplement observably alleviated these alterations in chicken kidney tissues induced by Cd. In conclusion, the dietary Lut supplement alleviated Cd-induced chicken kidney injury through its potent antioxidant properties by relieving the oxidative DNA damage-activated PARP-1-mediated reduction in SIRT1 activity and repairing autophagic flux blockade. Full article

Procedural sedation and analgesia (PSA) in the emergency department (ED) presents a crucial aspect of emergency medicine, enabling the execution of painful or distressing procedures with minimal patient discomfort. This narrative review delineates the pharmacological framework, methodologies, and clinical considerations integral to optimizing PSA, with a particular focus on pediatric and geriatric populations. Through a comprehensive review and analysis of current practices, this work evaluates the pharmacokinetics and pharmacodynamics of widely utilized sedatives and analgesics, including propofol, ketamine, dexmedetomidine, fentanyl, midazolam, etomidate, nitrous oxide, and remimazolam. Special attention is dedicated to the selection criteria based on patient-specific risk factors, procedural requirements, and the management of potential adverse effects. The manuscript also explores innovative sedation techniques and the integration of new pharmacological agents, emphasizing evidence-based approaches to enhance patient safety and outcome. The results underscore the significance of tailored sedation strategies, especially for vulnerable groups such as pediatric and geriatric patients, highlighting the need for meticulous pre-procedural assessment and monitoring to mitigate risks. The conclusions drawn advocate for a nuanced application of PSA, guided by current evidence and clinical guidelines, to improve the quality of care in emergency settings. This research reinforces the imperative for ongoing education, skill development, and the adaptation of new evidence into clinical practice to advance procedural sedation and analgesia in the ED. Full article

An electrothermal analysis for barium-titanate-based ceramics is presented, combining the Heywang–Jonker model for the electric resistivity with a heat dissipation mechanism based on natural convection and radiation in a one-dimensional model on the device level with voltage as the control parameter. Both positive-temperature-coefficient (PTC) and negative temperature coefficient (NTC) effects are accounted for through the double Schottky barriers at the grain boundaries of the material. The problem formulated in this way admits uniform and non-uniform multiple-steady-state solutions that do not depend on the external circuit. The numerical bifurcation analysis reveals that the PTC effect gives rise to several multiplicites above the Curie point, whereas the NTC effect is responsible for the thermal runaway (temperature blowup). The thermal runaway phenomenon as a potential thermal shock could be among the possible reasons for the observed thermomechanical failures (delamination fracture). The theoretical results for the NTC regime and the thermal runaway are in agreement with the experimental flash sintering results obtained for barium titanate, and 3% and 8% yttria-stabilized zirconia. Full article

This work presents the green synthesis of iron oxide nanoparticles (IONPs) using Baccharis salicifolia extract and their incorporation in mesoporous silica MCM-41, obtaining an MCM-41@IONP composite. The MCM-41@IONP composite was characterized by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), nitrogen adsorption and desorption, scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). The use of the natural reducing agent Baccharis salicifolia resulted in nanoparticles with an average size of 31 nm. Furthermore, we showcase the application of the MCM-41@IONP nanocomposite in a metal–insulator–semiconductor (MIS) diode, which was fabricated at room temperature. The current–voltage and capacitance–voltage curves of the MIS diode were carefully measured and subjected to detailed analysis. The results demonstrate the potential utility of MCM-41@IONP nanocomposite-based MIS diodes, suggesting their applicability in the design of biosensors or as discrete components in electronic devices. Full article

Aesthetic evaluation of increasingly complex and personalized human–computer interaction interfaces serves as a critical bridge between humans and machines, fundamentally enhancing various interaction factors. This study addresses the challenges in aesthetic evaluation by adjusting existing methodologies to incorporate seven aesthetic metrics: density, symmetry, balance, proportionality, uniformity, simplicity, and sequence. These metrics were effectively integrated into a composite evaluation metric through both multiple regression analysis and entropy methods, with the efficacy of both fitting methods validated. Leveraging automatic segmentation and recognition technology for interface screenshots, this research enables rapid, automated acquisition of evaluations for the seven metrics and the composite index, leading to the development of a prototype system for interface layout aesthetic assessment. Aimed at reducing the time, manpower, and resources required for interface evaluation, this study enhances the universality, compatibility, and flexibility of layout assessments. It promotes integration at any stage of the design process, significantly benefiting lightweight rapid evaluation and iterative design cycles, thereby advancing the field of interface aesthetic evaluation. Full article

Unanimous action to achieve specific goals is crucial for the success of a robotic swarm. This requires clearly defined roles and precise communication between the robots of a swarm. An optimized task allocation algorithm defines the mechanism and logistics of decision-making that enable the robotic swarm to achieve such common goals. With more nodes, the traffic of messages that are required to communicate inside the swarm relatively increases to maintain decentralization. Increased traffic eliminates real-time capabilities, which is an essential aspect of a swarm system. The aim of this research is to reduce execution time while retaining efficient power consumption rates. In this research, two novel decentralized swarm communication algorithms are proposed, namely Clustered Dynamic Task Allocation–Centralized Loop (CDTA-CL) and Clustered Dynamic Task Allocation–Dual Loop (CDTA-DL), both inspired by the Clustered Dynamic Task Allocation (CDTA) algorithm. Moreover, a simulation tool was developed to simulate different swarm-clustered communication algorithms in order to calculate the total communication time and consumed power. The results of testing the proposed CDTA-DL and CDTA-CL against the CDTA attest that the proposed algorithm consumes substantially less time. Both CDTA-DL and CDTA-CL have achieved a significant speedup of 75.976% and 54.4% over CDTA, respectively. Full article

Emergency department physicians uncommonly associate myopericarditis with bacterial infection and, even more rarely, encounter myopericarditis caused by meningococcal infection. This case report describes a 38-year-old man who presented with chest pain, electrocardiographic changes, and cardiac biomarkers consistent with acute myopericarditis and rapidly developed central nervous system symptoms that were concerning for acute bacterial meningitis. The diagnosis of Neisseria meningitidis infection was confirmed by blood cultures. Once identified, the patient made a full recovery following a course of intravenous antibiotic therapy. This case underscores the difficulty of diagnosing this rare, but potentially life-threatening, condition in the emergency department. Full article

This study explores the underground structure and soil retention capabilities of a large-scale circular diaphragm wall (93.5 m in diameter) utilized as a soil retention strategy in deep excavation projects. The symmetrical design of the wall facilitates the use of an unsupported construction method, effectively resisting soil and water pressures. Using PLAXIS 3D 2017 software, this study simulates wall deformation and ground settlement, employing three different soil models to assess behavior under standard and emergency water gushing scenarios. The results show that the hardening soil (HS) model most accurately reflects the actual deformations and settlements. This study also finds that adjusting Young’s modulus for clay significantly impacts the accuracy of soil behavior predictions, while changes in the properties of sand have minimal effects. This research highlights the challenges posed by water gushing and suggests the need for model improvements to capture better the dynamic interactions between soil and water pressure, which could lead to wall tilting. Overall, this study offers innovative and practical value, providing crucial insights for designing and mitigating strategies in large-scale circular deep excavation projects, especially in regions such as Taiwan, where such constructions are rare and face unique challenges. Full article