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Fluorine-containing heterocycles: XVIII. Monofluoro derivatives of quinazolines and 1,3-benzothiazin-4-ones

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Abstract

5- and 7-Fluoro-substituted quinazolines and 1,3-benzothiazin-4-ones were synthesized starting from 2-amino-6-fluorobenzonitrile and mono- and difluoro-substituted benzoic acid derivatives. The reactivities of di- and tetrafluoro-substituted benzoyl chlorides and benzoyl isothiocyanates in cyclocondensations leading to fluorinated quinazolines and 1,3-benzothiazines were compared.

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Authors and Affiliations

  1. Ural State Technical University, Yekaterinburg, Russia

    E. V. Nosova, A. A. Laeva, T. V. Trashakhova & A. V. Golovchenko

  2. Postovskii Institute of Organic Synthesis, Ural Division, Russian Academy of Sciences, ul. S. Kovalevskoi 22, Yekaterinburg, 620219, Russia

    G. N. Lipunova, P. A. Slepukhin & V. N. Charushin

Authors
  1. E. V. Nosova
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  2. A. A. Laeva
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  3. T. V. Trashakhova
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  4. A. V. Golovchenko
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  5. G. N. Lipunova
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  6. P. A. Slepukhin
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  7. V. N. Charushin
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Corresponding author

Correspondence to V. N. Charushin.

Additional information

Dedicated to Full Member of the Russian Academy of Sciences O. N. Chupakhin on his 75th anniversary

Original Russian Text © E.V. Nosova, A.A. Laeva, T.V. Trashakhova, A.V. Golovchenko, G.N. Lipunova, P.A. Slepukhin, V.N. Charushin, 2009, published in Zhurnal Organicheskoi Khimii, 2009, Vol. 45, No. 6, pp. 916–924.

For communication XVII, see [1].

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Nosova, E.V., Laeva, A.A., Trashakhova, T.V. et al. Fluorine-containing heterocycles: XVIII. Monofluoro derivatives of quinazolines and 1,3-benzothiazin-4-ones. Russ J Org Chem 45, 904–912 (2009). https://doi.org/10.1134/S1070428009060189

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  • DOI: https://doi.org/10.1134/S1070428009060189

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