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Nanocomposite hydrogel of poly(vinyl alcohol) and biocatalytically synthesized polypyrrole as potential system for controlled release of metoprolol

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Abstract

The inclusion of nanostructures into cross-linked polymer networks allows obtaining nanocomposite hydrogels with suitable multifuncionalities for drug delivery applications. In this work, polypyrrole (PPy) nanoparticles, synthesized by a biocatalytic route, were encapsulated into a hydrogel matrix of poly(vinyl alcohol) (PVA) during its reticulation with glutaraldehyde. The novel composite hydrogels were characterized by infrared spectroscopy, thermogravimetric analysis, swelling kinetic measurements, scanning electron microscopy and cyclic voltammetry. The loading capabilities of PVA/PPy hydrogels were tested for metoprolol, a beta blocker used to treat angina, hypertension and to prevent heart attack. In vitro drug release profiles were obtained without and under electrical stimulations. The kinetics of drug release exhibited a power-law time dependence, typical of hydrogel-based systems. The application of electrical potentials changed the release rate of the drug, increasing or decreasing the delivery rate depending on bias voltage. Composite system of PVA and PPy combines the electrochemical redox properties of the conductive polymer with the swelling capacity and molecular diffusivity associated with PVA network; therefore, it can be considered a potential stimuli-responsive platform for biomedical applications.

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Acknowledgements

Financial support from the University of Sonora (Project USO316002643) is gratefully acknowledged. This work was conducted within the proposal A1-S-26204 approved by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Grant Ciencia Básica 2017–2018. Annel Maricruz Orduño Rodríguez acknowledges CONACyT for the scholarship during this study.

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Authors and Affiliations

  1. Departamento de Investigación en Polímeros y Materiales, Universidad de Sonora, 83000, Hermosillo, Sonora, Mexico

    Annel Maricruz Orduño Rodríguez, Teresa del Castillo Castro, María Mónica Castillo Ortega & Dora Evelia Rodríguez Félix

  2. Departamento de Ciencias Químico Biológicas, Universidad de Sonora, 83000, Hermosillo, Sonora, Mexico

    Cinthia Jhovanna Pérez Martínez

  3. Centro de Investigación en Química Aplicada, 25100, Saltillo, Coahuila, Mexico

    Jorge Romero García

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  1. Annel Maricruz Orduño Rodríguez
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  2. Cinthia Jhovanna Pérez Martínez
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  3. Teresa del Castillo Castro
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  4. María Mónica Castillo Ortega
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  5. Dora Evelia Rodríguez Félix
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  6. Jorge Romero García
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Correspondence to Teresa del Castillo Castro.

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Orduño Rodríguez, A.M., Pérez Martínez, C.J., del Castillo Castro, T. et al. Nanocomposite hydrogel of poly(vinyl alcohol) and biocatalytically synthesized polypyrrole as potential system for controlled release of metoprolol. Polym. Bull. 77, 1217–1232 (2020). https://doi.org/10.1007/s00289-019-02788-x

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  • DOI: https://doi.org/10.1007/s00289-019-02788-x

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