Erratum to: Translational Modeling in Schizophrenia: Predicting Human Dopamine D₂ Receptor Occupancy

Erratum to: Pharm Res

DOI 10.1007/s11095-015-1846-4

There occurred two errors in the above manuscript (Pharm Res. 2015 Dec 30 [Epub ahead of print]). The correct information is as follows:

• 1) The differential equations in Appendix 2 should read:

  $$ \begin{array}{l}\begin{array}{l}\mathrm{d}\left({\mathrm{A}}_{\mathrm{bv}}\right)/\mathrm{d}\mathrm{t}=\left({\mathrm{CL}}_{\mathrm{bv}}/{\mathrm{V}}_{\mathrm{plasma}}\right)\ast {\mathrm{A}}_{\mathrm{plasma}}-\left({\mathrm{CL}}_{\mathrm{bv}}/{\mathrm{V}}_{\mathrm{bv}}\right)\ast {\mathrm{A}}_{\mathrm{bv}}-\left({\mathrm{CL}}_{\mathrm{bev}}/{\mathrm{V}}_{\mathrm{bv}}\right)\ast {\mathrm{fu}}_{\mathrm{plasma}}\ast {\mathrm{A}}_{\mathrm{bv}}\hfill \\ {}+\left({\mathrm{CL}}_{\mathrm{bev}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}+\left({\mathrm{CL}}_{\mathrm{eff}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}\hfill \end{array}\hfill \\ {}\begin{array}{l}\mathrm{d}\left({\mathrm{A}}_{\mathrm{bev}}\right)/\mathrm{d}\mathrm{t}=\left({\mathrm{CL}}_{\mathrm{bev}}/{\mathrm{V}}_{\mathrm{bv}}\right)\ast {\mathrm{fu}}_{\mathrm{plasma}}\ast {\mathrm{A}}_{\mathrm{bv}}-\left({\mathrm{CL}}_{\mathrm{bev}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}-\left({\mathrm{CL}}_{\mathrm{eff}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}\hfill \\ {}-\left({\mathrm{CL}}_{\mathrm{st}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}+\left({\mathrm{CL}}_{\mathrm{st}}/{\mathrm{V}}_{\mathrm{st}\mathrm{f}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{f}}\hfill \end{array}\hfill \\ {}\begin{array}{l}\mathrm{d}\left({\mathrm{A}}_{\mathrm{st}\mathrm{f}}\right)/\mathrm{d}\mathrm{t}=\left({\mathrm{CL}}_{\mathrm{st}}/{\mathrm{V}}_{\mathrm{bev}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{bev}}-\left({\mathrm{CL}}_{\mathrm{st}}/{\mathrm{V}}_{\mathrm{st}\mathrm{f}}\right)\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{f}}-\mathrm{k}\mathrm{o}\mathrm{n}\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{f}}\ast \left({\mathrm{B}}_{\max }-\mathrm{C}\mathrm{B}\right)\hfill \\ {}+\mathrm{koff}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{b}}\hfill \end{array}\hfill \\ {}\mathrm{d}\left({\mathrm{A}}_{\mathrm{st}\mathrm{b}}\right)/\mathrm{d}\mathrm{t}=\mathrm{k}\mathrm{o}\mathrm{n}\ast {\mathrm{fu}}_{\mathrm{brain}}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{f}}\ast \left({\mathrm{B}}_{\max }-\mathrm{C}\mathrm{B}\right)-\mathrm{ko}\mathrm{f}\mathrm{f}\ast {\mathrm{A}}_{\mathrm{st}\mathrm{b}}\hfill \end{array} $$

• 2) Table III should read:

  Table III In vitro, in vivo and ex vivo values estimates used in the human D₂RO predictive model.