In recent years, much effort has been devoted to understanding the response of plants to different light properties, largely due to advances in the light-emitting diode (LED) industry. This work studied the effect of different light intensities and qualities on yield or quality of indoor hydroponic spinach (Spinacia oleracea L.). Two trials were carried out at two different times. The intensity assay was carried out with the same type of light (AP673L, Valoya Ltd., Helsinki, Finland) at different luminous intensities (150, 290, and 430 µmol m⁻² s⁻¹). In the second trial, four different luminance spectra (Valoya Ltd., Helsinki, Finland) were used (NS12, AP67, AP673L, G2). Then, the fresh and dry weight, nutritional status, and concentration of primary metabolites were determined. Both lights parameters induced changes in vegetative performance and other physiological traits, as well as their quality and nutritional composition (minerals, organic acids, sugars, and amino acids). The increase in light intensity increased Fv’/Fv’, fresh weight, leaf area, chlorophyll fluorescence parameters, and potassium concentration. The light intensity effectively controlled nitrate accumulation in an inverse relationship. The effect of the light spectrum on spinach characteristics was not clearly observed when multivariate statistics were applied to the data. No linear relationship was found between the different R/B ratios. This is perhaps due to commercial lights having a complex combination of wavelengths, in addition to the main R/B proportion. Within the overall results, 6 R/B presented the best results for the indoor cultivation of spinach. More studies are needed, since breeding for controlled environments shifts the focus of the desired crop attributes towards rapid growth and harvest quality instead of stress adaptability. Full article

Mercury (Hg) is a pollutant that bioaccumulates in the food web, leading to health issues in humans and other fauna. Although anthropogenic Hg deposition has decreased over the past 20 years, our watersheds continue to be sources of Hg to downstream communities. Wetlands, especially peatlands in the Boreal Region of the globe, play a vital role in the formation of bioaccumulative methylmercury (MeHg). Few studies have assessed how increases in temperatures such as those that have already occurred and those predicted will influence the hydrologic transport of Hg to downstream communities or the net fluxes of gaseous Hg. The results indicate that peatland pore water concentrations of MeHg are increasing with ecosystem warming, and to some degree with elevated carbon dioxide (eCO₂) in the Spruce and Peatland Responses Under Changing Environments (SPRUCE) experiment at the Marcell Experimental Forest (MEF) in northern Minnesota, USA. Similar to SPRUCE, in the Biological Response to A Changing Environment (BRACE) experiment in Canada, mesocosm pore water MeHg concentrations increased with soil warming. However, long-term peatland watershed streamflow fluxes of MeHg at the MEF indicate that the competing effects of climate warming and decreased atmospheric deposition have led to overall decreases in watershed MeHg transport. Mesocosm studies in the PEATCOSM experiment in Upper Michigan, USA, indicate that simulated fluctuating water tables led to higher concentrations of MeHg in peatland pore water that is available for downstream transport when water tables rise and the next runoff event occurs. Results from a winter peatland soil freeze/thaw simulation from large mesocosm cores from Jennie’s Bog at the MEF indicate higher total Hg (THg) upon soil thawing but lower MeHg, likely a result of cold temperatures limiting methylation during thawing. Although there are lower MeHg concentrations after thawing, more THg is available for methylation once soils warm. Results from PEATCOSM and the literature also suggest that plant community changes that result in higher densities of sedges also lead to elevated MeHg in pore water. From a climate warming perspective, it appears that two complementary mechanisms, both related to decomposition, are at play that lead to increased pore water MeHg concentrations with warming. First, warming increases decomposition rates, leading to a higher availability of many ions, including Hg (and sulfur) species. Higher decomposition rates also lead to increases in soluble carbon which complexes with Hg species and assists in downstream hydrologic transport. However, if streamflow is decreasing with climate change as a result of landscape-level changes in evapotranspiration as suggested at MEF, the combination of less direct watershed Hg deposition and lower streamflow results in decreases in the watershed transport of MeHg. Given changes already occurring in extreme events and the rewetting and restoration of hydrology during peatland restoration, it is likely that methylation and pore water MeHg concentrations will increase. However, the landscape-level hydrologic cycle will be key to understanding the connection to downstream aquatic communities. Finally, gaseous Hg fluxes increase with warming and lead to decreases in peatland pools of Hg that may influence future availability for downstream transport. Full article

On a molecular level, glioma is very diverse and presents a whole spectrum of specific genetic and epigenetic alterations. The tumors are unfortunately resistant to available therapies and the survival rate is low. The explanation of significant intra- and inter-tumor heterogeneity and the infiltrative capability of gliomas, as well as its resistance to therapy, recurrence and aggressive behavior, lies in a small subset of tumor-initiating cells that behave like stem cells and are known as glioma cancer stem cells (GCSCs). They are responsible for tumor plasticity and are influenced by genetic drivers. Additionally, GCSCs also display greater migratory abilities. A great effort is under way in order to find ways to eliminate or neutralize GCSCs. Many different treatment strategies are currently being explored, including modulation of the tumor microenvironment, posttranscriptional regulation, epigenetic modulation and immunotherapy. Full article

An investigation into the evolution of temperature and stress fields, as well as the phase transformation in marine steel EH36 during multi-pass welding, and their subsequent effects on Charpy impact toughness, remains in great lack. In this study, submerged arc welding (SAW) was employed to carry out multi-pass welding on EH36 steel plates, followed by the low-temperature toughness test of weldments. Comsol software version 6.2 and finite element analysis are utilized to simulate the evolution of the microstructure, temperature, and residual stress fields throughout the multi-pass welding process. As welding progressed, the heat absorption along the vertical direction was enhanced; in contrast, a decrease is observed in the horizontal direction away from the heat source. This complicated temperature history favors the bainite transformation in the vicinity to the heat source, whereas areas more remote from the weld zone exhibit a higher prevalence of acicular ferrite due to the reduced cooling rate. The concentration of residual stress is predicted to occur at the boundary of the melt pool and at the interface between the weld and the heat-affected zone, with the greatest deformation observed near the fusion line at the top surface of the model. Furthermore, multi-pass welding may alleviate the residual stress, especially when coupled with the formation of acicular ferrite upon cooling, leading to improved low-temperature impact toughness in regions remote from the heat source. These findings offer valuable insights for the design and optimization of multi-pass welding in future applications. Full article

In response to the high breakage rate of pigeon eggs and the significant labor costs associated with egg-producing pigeon farming, this study proposes an improved YOLOv8-PG (real versus fake pigeon egg detection) model based on YOLOv8n. Specifically, the Bottleneck in the C2f module of the YOLOv8n backbone network and neck network are replaced with Fasternet-EMA Block and Fasternet Block, respectively. The Fasternet Block is designed based on PConv (Partial Convolution) to reduce model parameter count and computational load efficiently. Furthermore, the incorporation of the EMA (Efficient Multi-scale Attention) mechanism helps mitigate interference from complex environments on pigeon-egg feature-extraction capabilities. Additionally, Dysample, an ultra-lightweight and effective upsampler, is introduced into the neck network to further enhance performance with lower computational overhead. Finally, the EXPMA (exponential moving average) concept is employed to optimize the SlideLoss and propose the EMASlideLoss classification loss function, addressing the issue of imbalanced data samples and enhancing the model’s robustness. The experimental results showed that the F1-score, mAP50-95, and mAP75 of YOLOv8-PG increased by 0.76%, 1.56%, and 4.45%, respectively, compared with the baseline YOLOv8n model. Moreover, the model’s parameter count and computational load are reduced by 24.69% and 22.89%, respectively. Compared to detection models such as Faster R-CNN, YOLOv5s, YOLOv7, and YOLOv8s, YOLOv8-PG exhibits superior performance. Additionally, the reduction in parameter count and computational load contributes to lowering the model deployment costs and facilitates its implementation on mobile robotic platforms. Full article

The COVID-19 pandemic has influenced many fields, such as communication, commerce, and education, and pushed business entities to adopt innovative technologies to continue their business operations. Students need to do the same, so it is essential to understand their acceptance of these technologies to make them more usable for students. This paper employs the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) to identify the factors that influenced students’ acceptance and use of different online communication services as the primary tool for learning during the COVID-19 pandemic. Six factors of UTAUT2 were used to measure the acceptance and use of video communication services at the Business College of the University of Technology and Applied Sciences. Two hundred students completed our online survey. The results demonstrated that social influence, facilitating conditions, hedonic motivation, and habit affect behavioral intention positively, while performance expectancy and effort expectancy have no effect on behavioral intention. Full article

Marine biotoxins (MBs), harmful metabolites of marine organisms, pose a significant threat to marine ecosystems and human health due to their diverse composition and widespread occurrence. Consequently, rapid and efficient detection technology is crucial for maintaining marine ecosystem and human health. In recent years, rapid detection technology has garnered considerable attention for its pivotal role in identifying MBs, with advancements in sensitivity, specificity, and accuracy. These technologies offer attributes such as speed, high throughput, and automation, thereby meeting detection requirements across various scenarios. This review provides an overview of the classification and risks associated with MBs. It briefly outlines the current research status of marine biotoxin biosensors and introduces the fundamental principles, advantages, and limitations of optical, electrochemical, and piezoelectric biosensors. Additionally, the review explores the current applications in the detection of MBs and presents forward-looking perspectives on their development, which aims to be a comprehensive resource for the design and implementation of tailored biosensors for effective MB detection. Full article

Significant research endeavors have focused on microbial fuel cell (MFC) systems within wastewater treatment protocols owing to their unique capacity to convert chemical energy from waste into electricity while maintaining minimal nutrient concentrations in the effluent. While prior studies predominantly relied on empirical investigations, there remains a need to explore modeling and simulation approaches. Assessing MFC systems’ performance and power generation based on real wastewater data is pivotal for their practical implementation. To address this, a MATLAB model is developed to elucidate how MFC parameters and constraints influence system performance and enhance wastewater treatment efficiency. Leveraging actual wastewater data from a municipal plant in Guelph, Canada, six sets of MFC models are employed to examine the relationship between power generation and six distinct parameters (inflow velocity, membrane thickness, internal resistance, anode surface area, feed concentration, and hydraulic retention time). Based on these analyses, the final model projects a total power generation of 50,515.16 kW for the entire wastewater treatment plant in a day, capable of supporting approximately 2530 one-person households. Furthermore, the model demonstrates a notably higher chemical oxygen demand (COD) removal rate (75%) compared to the Guelph WWTP. This comprehensive model serves as a valuable tool for future simulations in similar wastewater treatment plants, providing insights for optimizing performance and aiding in practical applications. Full article

Understanding drought evolution and its driving factors is crucial for effective water resource management and forecasting. This study enhances the analysis of drought probability by constructing bivariate distributions, providing a more realistic perspective than single-characteristic approaches. Additionally, a meteorological drought migration model is established to explore spatiotemporal paths and related characteristics of major drought events in the Choushui River alluvial fan. The results reveal a significant increase in the probability of southward-moving drought events after 1981. Before 1981, drought paths were diverse, while after 1981, these paths became remarkably similar, following a trajectory from north to south. This is primarily attributed to the higher rainfall in the northern region of the Choushui River alluvial fan from February to April, leading to a consistent southward movement of drought centroids. This study proposes that climate change is a primary factor influencing changes in the spatiotemporal paths of drought. It implies that changes in rainfall patterns and climate conditions can be discerned through the meteorological drought migration model. As a result, it provides the potential for simplifying drought-monitoring methods. These research findings provide further insight into the dynamic process of drought in the Choushui River alluvial fan and serve as valuable references for future water resource management. Full article

Two new meroterpenoids, hyrtamide A (1) and hyrfarnediol A (2), along with two known ones, 3-farnesyl-4-hydroxybenzoic acid methyl ester (3) and dictyoceratin C (4), were isolated from a South China Sea sponge Hyrtios sp. Their structures were elucidated by NMR and MS data. Compounds 2–4 exhibited weak cytotoxicity against human colorectal cancer cells (HCT-116), showing IC₅₀ values of 41.6, 45.0, and 37.3 μM, respectively. Furthermore, compounds 3 and 4 significantly suppressed the invasion of HCT-116 cells while also downregulating the expression of vascular endothelial growth factor receptor 1 (VEGFR-1) and vimentin proteins, which are key markers associated with angiogenesis and epithelial–mesenchymal transition (EMT). Our findings suggest that compounds 3 and 4 may exert their anti-invasive effects on tumor cells by inhibiting the expression of VEGFR-1 and impeding the process of EMT. Full article

Hereditary neuropathy with liability to pressure palsies (HNPP) is an autosomal dominant demyelinating neuropathy characterized by an increased susceptibility to peripheral nerve injury from trauma, compression, or shear forces. Patients with this condition are unique, necessitating distinct considerations for anesthesia and surgical teams. This review describes the etiology, prevalence, clinical presentation, and management of HNPP and presents contemporary evidence and recommendations for optimal care for HNPP patients in the perioperative period. While the incidence of HNPP is reported at 7–16:100,000, this figure may be an underestimation due to underdiagnosis, further complicating medicolegal issues. With the subtle nature of symptoms associated with HNPP, patients with this condition may remain unrecognized during the perioperative period, posing significant risks. Several aspects of caring for this population, including anesthetic choices, intraoperative positioning, and monitoring strategy, may deviate from standard practices. As such, a tailored approach to caring for this unique population, coupled with meticulous preoperative planning, is crucial and requires a multidisciplinary approach. Full article

In order to evaluate the damage to tunnel cables caused by fire caused by leakage of transformer oil into a cable channel, the fire characteristics of different volumes of transformer oil flowing into a cable channel were analyzed by numerical simulation. The results show that when the total leakage of transformer oil is less than or equal to 3 L, the fire will end within 120 s, and when the total leakage is greater than or equal to 5 L, the fire duration will exceed 900 s. When the leakage amount is 1 L, the cable only burns slightly, and when the leakage amount is 3~12 L, the cable burns obviously. The combustion of the cable is mainly concentrated between 15 s and 75 s, and the overall combustion rate of the cable increases first and then decreases. When the total leakage is greater than or equal to 8 L, the damage distance of the middle and lower layer cable is the smallest. When the total leakage is less than or equal to 5 L, the damage distance of the lower layer cable is the smallest, and the damage distance of the lower layer cable, middle and lower layer cable, and middle and upper layer cable is less than half of the length of the cable channel. Full article

In recent years, immuno-oncology has revolutionized the cancer treatment field by harnessing the immune system’s power to counteract cancer cells. While this innovative approach holds great promise for improving cancer outcomes, it also raises important considerations related to fertility and reproductive toxicity. In fact, most young females receiving gonadotoxic anti-cancer treatments undergo iatrogenic ovarian exhaustion, resulting in a permanent illness that precludes the vocation of motherhood as a natural female sexual identity. Although commonly used, oocyte cryopreservation for future in vitro fertilization and even ovarian cortex transplantation are considered unsafe procedures in cancer patients due to their oncogenic risks; whereas, ovarian stem cells might support neo-oogenesis, providing a novel stemness model of regenerative medicine for future fertility preservation programs in oncology. Recent scientific evidence has postulated that immune checkpoint inhibitors (ICIs) might in some way reduce fertility by inducing either primary or secondary hypogonadism, whose incidence and mechanisms are not yet known. Therefore, considering the lack of data, it is currently not possible to define the most suitable FP procedure for young patients who are candidates for ICIs. In this report, we will investigate the few available data concerning the molecular regulation of ICI therapy and their resulting gonadal toxicity, to hypothesize the most suitable fertility preservation strategy for patients receiving these drugs. Full article

Differentiated HepaRG cells are popular in vitro cell models for hepatotoxicity studies. Their differentiation is usually supported by the addition of dimethyl sulfoxide (DMSO), an amphipathic solvent widely used in biomedicine, for example, in potential novel therapeutic drugs and cryopreservation of oocytes. Recent studies have demonstrated drastic effects, especially on epigenetics and extracellular matrix composition, induced by DMSO, making its postulated inert character doubtful. In this work, the influence of DMSO and DMSO-mediated modulation of differentiation on human adenovirus (HAdV) infection of HepaRG cells was investigated. We observed an increase in infectivity of HepaRG cells by HAdVs in the presence of 1% DMSO. However, this effect was dependent on the type of medium used for cell cultivation, as cells in William’s E medium showed significantly stronger effects compared with those cultivated in DMEM. Using different DMSO concentrations, we proved that the impact of DMSO on infectability was dose-dependent. Infection of cells with a replication-deficient HAdV type demonstrated that the mode of action of DMSO was based on viral entry rather than on viral replication. Taken together, these results highlight the strong influence of the used cell-culture medium on the performed experiments as well as the impact of DMSO on infectivity of HepaRG cells by HAdVs. As this solvent is widely used in cell culture, those effects must be considered, especially in screening of new antiviral compounds. Full article

Horizontal wells within the roof are an effective method to develop gas in broken and soft coal seams, and layer-penetrating fracturing is a key engineering method for the stimulating of horizontal wells within the roof of a coal seam. To understand the propagation law of fracture in the composite roof of coal seams, this study conducted research using numerical simulation and physical similarity simulation methods. Furthermore, engineering experiments were carried out at the Panxie coal mine in the Huainan Mining Area and the Luling coal mine in Huaibei Mining Area, to further validate this technology. The numerical simulation results indicated that fracture within the coal seam roof can propagate from the roof to the target coal seam, effectively fracturing the coal seam. Due to the coal seam’s plasticity being greater than that of the roof mudstone, the coal seam forms a broader fracture than the roof. With the increase in pseudo roof mudstone thickness and being under constant fracturing displacement, the energy consumed by the pseudo roof mudstone during fracturing causes a decrease in pore pressure when fracture extends to the coal seam, resulting in a reduction in fracture width. Therefore, the pseudo roof mudstone is an adverse factor for the expansion of hydraulic fracturing. Physical similarity simulation results demonstrated that when horizontal boreholes were arranged within the siltstone of the coal seam roof, were under reasonable vertical distance and high flow rate fracturing via fluid injection conditions, and if the coal seam had a thin pseudo roof mudstone, the fracture could propagate through the direct roof-pseudo roof interface and the pseudo roof-coal seam interface, extending to the lower coal seam. The fracture form was curved and had irregular vertical fractures, indicating that hydraulic fracturing can achieve production enhancement and the transformation of soft and hard coal seams. However, when the coal seam had a thick pseudo roof mudstone, the mudstone posed strong resistance to hydraulic fracturing, making it difficult for the fracture to propagate to the lower coal seam. Therefore, the pseudo roof mudstone plays a detrimental role in hydraulic fracturing and the production enhancement of coal seams. The engineering verification conducted at Panxie coal mine and Luling coal mine showed that by utilizing a construction drainage rate of 7.5 cubic meters per minute at Panxie coal mine, the maximum fracture length reached 218.3 m, with a maximum fracture height of 36.8 m. The maximum daily gas production of a single well reached 1450 cubic meters per day, with a total gas extraction volume of 43.62 × 10⁴ cubic meters across 671 days. At Luling coal mine, utilizing a construction drainage rate of 10 cubic meters per minute, the maximum fracture length reached 169.1 m, with a maximum fracture height of 20.5 m. The maximum daily gas production of a single well reached 10,775 cubic meters per day, with a total gas extraction volume of 590 × 10⁴ cubic meters for 1090 days. This indicated that the fracture within the roof of coal seams can penetrate the composite roof of coal seams and extend to the interior of the coal seams, achieving the purpose of transforming fractured and low-permeability coal seams and providing an effective mode of gas extraction. Full article

Nephrotic range proteinuria in the setting of dual-positive anti-glomerular basement membrane (AGBM) and anti-neutrophil cytoplasmic antibodies (ANCAs) is rare. Furthermore, using rituximab as a primary immunosuppressant along with steroids and plasmapheresis has not been widely studied. We present a case of dual AGBM and ANCA with nephrotic range proteinuria in a young female, where rituximab was used as a primary immunosuppressant with partial recovery. Full article

Exploring the characteristics of vegetation dynamics and quantitatively analyzing the potential drivers and the strength of their interactions are of great significance to regional ecological environmental protection and sustainable development. Therefore, based on the 2000–2022 MODIS NDVI dataset, supplemented by climatic, topographic, surface cover, and anthropogenic data for the same period, the Sen+Mann–Kendall trend analysis, coefficient of variation, and Hurst exponent were employed to examine the spatial and temporal characteristics and trends of NDVI in Hubei Province, and a partial correlation analysis and geographical detector were used to explore the strength of the influence of driving factors on the spatial differentiation of NDVI in vegetation and the underlying mechanisms of interaction. The results showed that (1) the mean NDVI value of vegetation in Hubei Province was 0.762 over 23 years, with an overall increasing trend and fluctuating upward at a rate of 0.01/10a (p < 0.005); geospatially, there is a pattern of “low east and high west”; the spatial change in NDVI shows a trend of “large-scale improvement in the surrounding hills and mountains and small-scale degradation in the middle plains”; it also presents the spatial fluctuation characteristics of “uniform distribution in general, an obvious difference between urban and rural areas, and a high fluctuation of rivers and reservoirs”, (2) the future trend of NDVI in 70.76% of the region in Hubei Province is likely to maintain the same trend as that of the 2000–2022 period, with 70.78% of the future development being benign and dominated by sustained improvement, and (3) a combination of partial correlation analysis and geographical detector analysis of the drivers of vegetation NDVI change shows that land cover type and soil type are the main drivers; the interactions affecting the distribution and change characteristics of NDVI vegetation all showed two-factor enhancement or nonlinear enhancement relationships. This study contributes to a better understanding of the change mechanisms in vegetation NDVI in Hubei Province, providing support for differentiated ecological protection and project implementation. Full article

This study investigated the catalytic properties of low-temperature oxidation of carbon monoxide, focusing on (Y_0.2La_0.2Nd_0.2Gd_0.2Sm_0.2)CoO₃ synthesized via a glycothermal method using 1,4-butanediol and diethylene glycol at 250 °C. This synthesis route bypasses the energy-intensive sintering process at 1200 °C while maintaining a high-entropy single-phase structure. The synthesized material was characterized structurally and chemically by X-ray diffraction and SEM/EDX analyses. The material was shown to form nanofibers of (Y_0.2La_0.2Nd_0.2Gd_0.2Sm_0.2)CoO₃, thereby increasing the active surface area for catalytic reactions, and crystallize in the model Pbnm space group of distorted perovskite cell. Using a custom setup to investigate catalytic properties of (Y_0.2La_0.2Nd_0.2Gd_0.2Sm_0.2)CoO₃, the CO oxidation behavior of those high-entropy perovskite oxide was investigated, showing an overall conversion of 78% at 50 °C and 97% at 100 °C. These findings highlight the effective catalytic activity of nanofibers of (Y_0.2La_0.2Nd_0.2Gd_0.2Sm_0.2)CoO₃ under mild conditions and their versatility in various catalytic processes of robust CO neutralization. The incorporation of rare-earth elements into a high-entropy structure could impart unique catalytic properties, promoting a synergistic effect that enhances performance. Full article

Microcystins (MCs), natural hepatotoxic compounds produced by cyanobacteria, pose significant risks to water quality, ecosystem stability, and the well-being of animals, plants, and humans when present in elevated concentrations. The escalating contamination of irrigation water with MCs presents a growing threat to terrestrial plants. The customary practice of irrigating crops from local water sources, including lakes and ponds hosting cyanobacterial blooms, serves as a primary conduit for transferring these toxins. Due to their high chemical stability and low molecular weight, MCs have the potential to accumulate in various parts of plants, thereby increasing health hazards for consumers of agricultural products, which serve as the foundation of the Earth’s food chain. MCs can bioaccumulate, migrate, potentially biodegrade, and pose health hazards to humans within terrestrial food systems. This study highlights that MCs from irrigation water reservoirs can bioaccumulate and come into contact with plants, transferring into the food chain. Additionally, it investigates the natural mechanisms that organisms employ for conjugation and the microbial processes involved in MC degradation. To gain a comprehensive understanding of the role of MCs in the terrestrial food chain and to elucidate the specific health risks associated with consuming crops irrigated with water contaminated with these toxins, further research is necessary. Full article

Chronic inflammation is a significant contributor to the development of cancer, cardiovascular disease, diabetes, obesity, autoimmune disease, inflammatory bowel disease, and other illnesses. In the academic field, there is a constant demand for effective methods to alleviate inflammation. Astragalin (AST), a type of flavonoid glycoside that is the primary component in several widely used traditional Chinese anti-inflammatory medications in clinical practice, has garnered attention from numerous experts and scholars. This article focuses on the anti-inflammatory effects of AST and conducts research on relevant literature from 2003 to 2023. The findings indicate that AST demonstrates promising anti-inflammatory potential in various models of inflammatory diseases. Specifically, AST is believed to possess inhibitory effects on inflammation-related factors and protein levels in various in vitro cell models, such as macrophages, microglia, and epithelial cells. In vivo studies have shown that AST effectively alleviates neuroinflammation and brain damage while also exhibiting potential for treating moderate diseases such as depression and stroke; it also demonstrates significant anti-inflammatory effects on both large and small intestinal epithelial cells. Animal experiments have further demonstrated that AST exerts therapeutic effects on colitis mice. Molecular biology studies have revealed that AST regulates complex signaling networks, including NF-κB, MAPK, JAK/STAT pathways, etc. In conclusion, this review will provide insights and references for the development of AST as an anti-inflammatory agent as well as for related drug development. Full article