Abstract
HEp-2 cells, which were infected with HSV-1, excrete besides other proteins a soluble glycoprotein (Mr 125000–130000) related to the virus protein gC. The excretion of the glycoprotein and the production of extracellular virus particles is reduced to a similar extent when the cells were treated with monensin. Possible consequences of the excretion of soluble viral proteins to a modulation of the immune response are discussed.
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Abbreviations
- HSV-1:
-
Herpes simplex virus type 1
- PAGE:
-
Polyacrylamide gel electrophoresis
- SDS:
-
Sodium dodecylsulfate
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Tiedemann, K.H., Hampl, H. & Habermehl, K.O. Release of a virus coded glycoprotein from herpes simplex virus type 1 infected cells. Mol Biol Rep 13, 29–33 (1988). https://doi.org/10.1007/BF00805636
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DOI: https://doi.org/10.1007/BF00805636