Abstract
Evidence is presented for the existence of two strong murine teratocarcinoma transplantation antigens (Gt) on the cell line PCC3. It is shown that the loci governing expression of these antigens are linked to the H-2 complex. These loci have been further mapped with respect to the brachyury marker (T) and H-2: Gt-1 lies 5±2 crossover units proximal to H-2 and 12±2 crossover units distal to T, Gt-2 lies 21±4 crossover units distal to H-2. It is possible that these strong transplantation antigens provide an embryonic analogue to the adult major histocompatibility system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Avner, P. R., Dove, W. F., Dubois, P., Gaillard, J. A., Guenet, J.-L., Jacob, F., Jakob, H., and Shedlovsky, A.: The genetics of teratocarcinoma transplantation: Tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3. Immunogenetics 7: 103–115, 1978
Bishop, G. A. and Dove, W. F.: Semisyngeneic hybrid resistance to murine teratocarcinoma cells. Immunogenetics 10: 383–393, 1980
Boon, T., Van Pel, A., and Warmer, G.: Mouse teratocarcinoma cell variants obtained by mutagenesis: rejection by syngeneic mice and immunization against the original tumor cell line. In H. Peters (ed.): Protides of Biological Fluids. 27th Colloquium 1979. Pergamon Press, Oxford and New York, 1979
Dobrovolskaia-Zavadskaia, N.: Sur la mortification spontanee de la queue chez la souris nouveau-nee et sur l'existance d'un caractere (facteur) hereditaire “non viable”. C. R. Soc. Biol. 97: 114–116, 1927
Erickson, R. P. and Lewis, S. E.: Cell surfaces and embryos: Expression of the F9 teratocarcinoma antigen in T-region lethal, other lethal, and normal pre-implantation mouse embryos. J. Reprod. Immunol. 2: 293–304, 1980
Flaherty, L.: H-33—a histocompatibility locus to the left of the H-2 complex. Immunogenetics 2: 325–329, 1975
Heyner, S. and Hunziker, R. D.: Differentiation and expression of alloantigens of the major histocompatibility complex on unfertilized and fertilized mouse eggs. Developmental Genetics 1: 69–76, 1979
Jacob, F.: Mouse teratocarcinoma and embryonic antigens. Immunol. Rev. 33: 3–32, 1977
Katz, D. H., Hamaoka, T., Dorf, M. E., and Benacerraf, B.: Cell interactions between histoincompatible T and B lymphocytes. The H-2 gene complex determines successful physiologic lymphocyte interactions. Proc. Natl. Acad. Sci. U.S.A. 70: 2624–2628, 1973
Kemler, R., Babinet, C., Condamine, H., Gachelin, G., Guenet, J.-L., and Jacob, F.: Embryonal carcinoma antigen and the T/t locus of the mouse. Proc. Natl. Acad. Sci. U.S.A. 73: 4080–4084, 1976
Kiessling, R. and Wigzell, H.: An analysis of the marine NK cell as to structure, function and biological relevance. Immunol. Rev. 44: 165–208, 1979
Klein, J.: Biology of the Mouse Histocompatibility-2 Complex. Principles of Immunogenetics Applied to a Single System. Springer-Verlag, New York, 1975
Kralova, J. and Lengerova, A.: H-Y antigen: Genetic control of the expression as detected by hostversus-graft popliteal lymph node enlargement assay maps between the T and H-2 complexes. J. Immunogenet. 6: 429–438, 1979
Levine, A. J. and Teresky, A. K.: Teratocarcinoma transplantation rejection loci: genetic localization of the Gt-1 locus on chromosome 17 and the expression of alternate alleles. Immunogenetics 13: 405–412 1981
Marticorena, P., Artzt, K., and Bennett, D.: Relationship of F 9 antigen and genes of the T/t complex. Immunogenetics 7: 337–347, 1978
McDevitt, H. O., Deak, B. D., Shreffler, D. C., Klein, J., Stimpfling, J. H., and Snell, G. D.: Genetic control of the immune response. Mapping of the Ir-1 locus. J. Exp. Med. 135: 1259–1278, 1972
Murphy, D. B. and Shreffler, D. C.: Cross-reactivity between H-2K and H-2D products. I. Evidence for extensive and reciprocal serological cross-reactivity. J. Exp. Med. 141: 374–391, 1975
Ostrand-Rosenberg, S., Rider, T. M., and Twarowski, A.: Susceptibility of allogencic mice to teratocarcinoma 402AX. Immunogenetics 10: 607–612, 1980
Siegler, E. L., Tick, N., Teresky, A. K., Rosenstraus, M., and Levine, A. J.: Teratocarcinoma transplantation rejection loci: an H-2-linked tumor rejection locus. Immunogenetics 9: 207–220, 1979
Snell, G. D.: The genetics of transplantation. J. Natl. Cancer Inst. 14: 691–700, 1953
Stern, P., Gidlund, M., Orn, A., and Wigzell, H.: Natural killer cells mediate lysis of embryonal carcinoma cells lacking MHC. Nature 285: 341–342, 1980
Stevens, L. C.: A developmental genetic approach to the study of teratocarcinogenesis. BioScience 23: 169–172, 1973
Zaleski, M. and Klein, J.: Immune response of mice to Thy-1.1 antigen: Genetic control by alleles at the Ir-5 locus loosely linked to the H-2 complex. J. Immunol. 113: 1170–1177, 1974
Zinkernagel, R. M. and Doherty, P. C.: Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 248: 701–702, 1974
Zinkernagel, R. M. and Doherty, P. C.: H-2 compatibility requirement for T-cell-mediated lysis of target cells infected with lymphocyte choriomeningitis virus. J. Exp. Med. 141: 1427–1436, 1975
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shedlovsky, A., Clipson, L.J., VandeBerg, J.L. et al. Strong teratocarcinoma transplantation loci, Gt-1 and Gt-2, Flank H-2 . Immunogenetics 13, 413–419 (1981). https://doi.org/10.1007/BF00346022
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00346022