Skip to main content
Log in

Three rare G-6-PD variants from Porto Alegre, Brazil

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

Studies in 772 children and their mothers living in Porto Alegre, Brazil, disclosed three rare G-6-PD phenotypes. The first, observed in a dark mulatto, is probably identical to a variant previously found in Northeastern Brazil and was named Gd Minas Gerais-like; a white boy of German ancestry showed what seems to be Seattle-like; and a white man of Portuguese ancestry presented a previously undescribed variant that is being called Gd Porto Alegre. The allele responsible for Gd Minas Gerais may be more prevalent in Brazilian populations than was previously thought. Its estimated frequency in 214 black males from Porto Alegre is 0.005.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Azevedo, E. S., Yoshida, A.: Brazilian variant of glucose-6-phosphate dehydrogenase (Gd Minas Gerais). Nature 222, 380–382 (1969)

    PubMed  Google Scholar 

  • Beutler, E., Mathai, C. K., Smith, J. E.: Biochemical variants of glucose-6-phosphate dehydrogenase giving rise to congenital non-spherocytic hemolytic disease. Blood 31, 131–150 (1968)

    PubMed  Google Scholar 

  • Beutler, E., Yoshida, A.: Human glucose-6-phosphate dehydrogenase variants: a supplementary tabulation. Ann. Hum. Genet. 37, 151–155 (1973)

    PubMed  Google Scholar 

  • Carson, P. E., Flanagan, C. L., Ickes, C. E., Alving, A. S.: Enzymatic deficiency in primaquinesensitive erytrocytes. Science 124, 484–485 (1956)

    Google Scholar 

  • Fildes, R. A., Parr, C. W.: Human red cell phosphogluconate dehydrogenases. Nature 200, 890–891 (1963)

    PubMed  Google Scholar 

  • Gherardi, M., Bierme, R., Corberand, J., Pris, J., Vergnes, H.: Distribution of G-6-PD types in the population of Southwest France: common variants and new variants. Hum. Hered. 26, 279–289 (1976)

    PubMed  Google Scholar 

  • Kahn, A., Boivin, P., Lagneau, I., Gruveillier, J.: Déficit en glucose-6-phosphate déshydrogénase lié à la présence d'une variante lente dans une famille française. Rapports avec la variante Gd(-) Seattle. Nouv. Rev. Fr. Hematol. 13, 163–172 (1973)

    PubMed  Google Scholar 

  • Kirkman, H. N., Simon, E. R., Pickard, B. M.: Seattle variant of glucose-6-phosphate dehydrogenase. J. Lab. Clin. Med. 66, 834–840 (1965)

    PubMed  Google Scholar 

  • Lenzerini, L., Meera Khan, P., Filippi, G., Rattazzi, M. C., Ray, A. K., Siniscalco, M.: Characterization of glucose-6-phosphate dehydrogenase variants. I. Occurrence of a G-6-PD Seattle-like variant in Sardinia and its interaction with the G-6-PD Mediterranean variant. Am. J. Hum. Genet. 21, 142–153 (1969)

    PubMed  Google Scholar 

  • Motulsky, A. G., Yoshida, A.: Methods for the study of red cell glucose-6-phosphate dehydrogenase. In: Biochemical methods in red cell genetics, J. J. Yunis, ed., pp. 51–93. New York: Academic Press 1969

    Google Scholar 

  • Rattazzi, M. C., Lenzerini, L., Meera Khan, P., Luzzatto, L.: Characterization of glucose-6-phosphate dehydrogenase variants. II. G-6-PD Kephalonia, G-6-PD Attica, and G-6-PD “Seattle-like” found in Greece. Am. J. Hum. Genet. 21, 154–167 (1969)

    PubMed  Google Scholar 

  • Yoshida, A., Beutler, E., Motulsky, A. G.: Human glucose-6-phosphate dehydrogenase variants. Bull. W.H.O. 45, 243–253 (1971a)

    PubMed  Google Scholar 

  • Yoshida, A., Watanabe, S., Gartler, S. M.: Identification of Hela cell glucose-6-phosphate dehydrogenase. Biochem. Genet. 5, 533–539 (1971b)

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hutz, M.H., Yoshida, A. & Salzano, F.M. Three rare G-6-PD variants from Porto Alegre, Brazil. Hum Genet 39, 191–197 (1977). https://doi.org/10.1007/BF00287011

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00287011

Keywords

Navigation