Summary
Phenylbutazone treatment can cause digestive-tract hemorrhages, but its concentration in the blood at the time of hemorrhage is generally not known. In two patients who had had digestive tract hemorrhages, the variation in the serum phenylbutazone concentration throughout treatment and just before hemorrhage was simulated by a two-compartment model based on assays (gas-liquid chromatography) made after the hemorrhage. Identification of the parameters of the model and simulation of changes in concentration during therapy suggested that the phenylbutazone level in serum at the time of hemorrhage was 101 and 125 µg/ml respectively.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bruck, E., Fearnley, M. E., Meanock, I., Patley, H.: Phenylbutazone therapy: relations between the toxic and therapeutic effects and the blood level. Lancet1954/I, 225–227
Monot, C.: Ajustement numérique d'un système différentiel linéaire à l'aide de la transformation de Laplace. Thèse de Doctorat de troisième cycle Mathématiques, Nancy (1967)
Netter, P.: Pharmacologie clinique de la Phénylbutazone. Thèse de Doctorat en Médecine, Nancy (1977)
Perego, R., Martinelli, E., Vanconi, P. C.: Gas chromatographic assay of phenylbutazone in biological fluids. J. Chromatogr.54, 280–285 (1971)
Tophoj, E. A.: Blood phenylbutazone levels, after treatment in low dosage. Acta med. scand.160, 197–203 (1958)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Monot, C., Faure, G., Netter, P. et al. Model for retrospective estimation of serum levels of phenylbutazone: Application to two cases of digestive tract hemorrhage. Eur J Clin Pharmacol 13, 439–443 (1978). https://doi.org/10.1007/BF00566323
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00566323