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A lack of effect of captopril on platelet aggregation in patients with congestive heart failure

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Summary

We have studied the acute and chronic effects of an ACE inhibitor (captopril) on platelet function and the renin-angiotensin system in patients with congestive heart failure.

Plasma concentrations of angiotensin II fell significantly after a single dose of captopril (25 mg) and during long-term treatment with captopril (2 weeks, 75 mg/day). Plasma renin activity increased significantly after both the single and repeated doses.

Captopril did not affect ADP-induced platelet aggregation or concentrations. It seems unlikely that circulating angiotensin II affects ADP-induced platelet aggregation in patients with congestive heart failure.

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Authors and Affiliations

  1. Departments of Medicine and Cardiology, Western General Hospital, EH4 2XU, Edinburgh, UK

    I. F. Gow, A. D. Flapan, M. Morris, E. Davies, B. C. Williams, P. L. Padfield, T. R. D. Shaw & C. R. W. Edwards

  2. Department of Physiology, Medical School, Teviot Place, EH8 9AG, Edinburgh, UK

    I. F. Gow

Authors
  1. I. F. Gow
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  2. A. D. Flapan
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  3. M. Morris
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  4. E. Davies
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  5. B. C. Williams
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  6. P. L. Padfield
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  7. T. R. D. Shaw
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  8. C. R. W. Edwards
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Gow, I.F., Flapan, A.D., Morris, M. et al. A lack of effect of captopril on platelet aggregation in patients with congestive heart failure. Eur J Clin Pharmacol 41, 47–49 (1991). https://doi.org/10.1007/BF00280105

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  • DOI: https://doi.org/10.1007/BF00280105

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