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CYP2D6 and GSTM1 genotypes in a Polish population

  • PHARMACOKINETICS AND DISPOSITION
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Abstract

Objective: The aim of the present study was to investigate the distribution of the CYP2D6 and GSTM1 genotypes in a Polish population.

Methods: One hundred and forty-five unrelated healthy individuals from the western region of Poland were studied. The CYP2D6 genotype was analysed by means of polymerase chain reaction (PCR) amplification for the CYP2D6 * 3 and CYP2D6 * 4 alleles. The GSTM1 genotype was also analysed by means of a PCR assay to determine two genotypes: GSTM1-1 (positive) and GSTM1-0 (negative).

Results: Fourteen subjects (9.6%) were classified as poor metabolisers. The frequency of CYP2D6 * 4 and CYP2D6 * 3 was 23.1% and 2.1%, respectively. The frequency of GSTM1 nulled genotype in a Polish population came to 49%.

Conclusion: The frequencies of poor metabolisers for CYP2D6 and GSTM1 nulled genotype among a Polish population were similar to those observed in other Caucasian populations.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Laboratory of Pharmacokinetics and Monitoring Therapy, Medical University, Powstanców Wlkp. 72, PL-70-111 Szczecin, Poland e-mail: gszklarz@r1.pam.szczecin.pl Tel.: +48-91-4820863; Fax: +48-91-4828539, , , , , , PL

    B. Gawronska-Szklarz, A. Kuprianowicz, K. Kedzierska, M. Kedzierski, W. Górnik & A. Pawlik

  2. Department of General and Transplantation Surgery, Medical University, Powstanców Wlkp. 72, 70-111 Szczecin, Poland, , , , , , PL

    M. Wójcicki

Authors
  1. B. Gawronska-Szklarz
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  2. M. Wójcicki
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  3. A. Kuprianowicz
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  4. K. Kedzierska
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  5. M. Kedzierski
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  6. W. Górnik
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  7. A. Pawlik
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Additional information

Received: 29 October 1998 / Accepted in revised form: 15 March 1999

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Gawronska-Szklarz, B., Wójcicki, M., Kuprianowicz, A. et al. CYP2D6 and GSTM1 genotypes in a Polish population. E J Clin Pharmacol 55, 389–392 (1999). https://doi.org/10.1007/s002280050645

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  • DOI: https://doi.org/10.1007/s002280050645

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