Abstract
We report the characterization of a cell-cell adhesion molecule identified by mAbBD31 on human epithelioid cells. This glycoprotein shows cadherin features but appears to be truncated being devoid of the transmembrane and cytoplasmic domains. It is directly membrane-anchored by a GPI moiety. We propose to call this molecule HT-cadherin.
Similar content being viewed by others
References
Asaoka, Y., Nakamura, S., Yoshida, K., and Nishizuka, Y. (1992) ‘Protein kinase C, calcium and phospholipid degradation’, TIBS 17, 414–417.
Damsky, C. H., and Werb, Z. (1992) ‘Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information’, Curr. Opin. Cell Biol. 4, 772–781.
Kemler, R. 1992. ‘Classical cadherins’, Sem. Cell Biol. 3, 149–155.
Liskovitch, M. (1992) ‘Crosstalk among multiple signal-activated phospholipases’, TIBS 17, 393–399.
Low, M. G., and Prasad, A. R. S. (1988) ‘A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma’, Proc. Natl. Acad. Sci. USA 85, 980–984.
Moolenaar, W. H., Kruijer, W., Tilly, B. C., Verlaan, I., Bierman, A. J., and de Laat, S. W. (1986) ‘Growth factor-like action of phosphatidic acid’, Nature 323, 171–173.
Murayama, T., and Ui, M. (1987) ‘Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts’, J. Biol. Chem. 262, 5522–5529.
Prat, M., Rossino, P., Marchisio, P. C., Comoglio, P. M., and Corbascio, G. C. (1986) ‘Identification of a glycoprotein expressed in cell-cell contacts by means of a monoclonal antibody’, Cell Biol. Int. Rep. 10, 159.
Ranscht, B., and Dours-Zimmermann, M. T. (1991) ‘T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region’, Neuron 7, 391–402.
Takeichi, M. (1990) ‘Cadherins: a molecular family important in selective cell-cell adhesion’, Annu. Rev. Biochem. 59, 237–252.
Takeichi, M. (1991) ‘Cadherin cell adhesion receptors as a morphogenetic regulator’, Science 251, 1451–1455.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Trusolino, L., Rabino, M., Prat, M. et al. A novel GPI-anchored glycoprotein shows properties of a coohterminus truncated cadherin involved in cell-cell contacts of cultured human epithelial cells. Cytotechnology 11 (Suppl 1), S97–S99 (1993). https://doi.org/10.1007/BF00746067
Issue Date:
DOI: https://doi.org/10.1007/BF00746067