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Encapsulation of caffeine in polysaccharide oil-core nanocapsules

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Abstract

Nanoemulsion droplets stabilized with a polysaccharide multilayer film were used as carriers for caffeine. Multilayered shells were formed through a subsequent layer-by-layer adsorption of oppositely charged chitosan and alginate (sodium salt) onto emulsion droplets or oil-core nanocapsules at low ionic strength. The hydrophilic positively charged molecules of the drug were impregnated into the film after each alginate layer. The experimental results showed dependence of the encapsulation efficiency of caffeine on the number of the adsorbed polymer layers and on the properties of chitosan used for formation of the film (molecular weight and degree of acetylation). Despite the low encapsulation efficiency of the drug into the capsules (~ 40%) compared with other encapsulation systems, the amount loaded into the film was high enough and pharmacological doses were achieved with very small volumes of the dispersion.

Encapsulation of caffeine in polysaccharide multilayered oil-core nanocapsules

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Acknowledgments

The investigation is performed under the umbrella of COST Action CA18238 (Ocean4Biotech) - “European transdisciplinary networking platform for marine biotechnology.” V.M. thanks Dr. Tamara Mengoni and Dr. Xiaofei Qin for their support for HPLC measurements. We thank Rosie Owens for her support in editing the document.

Funding

This work is supported by the EC project Nano3Bio (FP7-KBBE-2013-7).

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Authors and Affiliations

  1. Institut für Biology und Biotechnologie der Pflanzen, Westfälische Wilhems-Universität Münster, Schlossgarten 3, 48149, Münster, Germany

    Viktoria Milkova & Francisco M. Goycoolea

  2. Institute of Physical Chemistry, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

    Viktoria Milkova

  3. School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK

    Francisco M. Goycoolea

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  1. Viktoria Milkova
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Correspondence to Viktoria Milkova.

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Milkova, V., Goycoolea, F.M. Encapsulation of caffeine in polysaccharide oil-core nanocapsules. Colloid Polym Sci 298, 1035–1041 (2020). https://doi.org/10.1007/s00396-020-04653-0

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  • DOI: https://doi.org/10.1007/s00396-020-04653-0

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