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IMMUNOTHERAPY

Collagen-binding IL-12 inflames ‘cold’ tumours

Nature Biomedical Engineering volume 4, pages 483–484 (2020)Cite this article

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The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.

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Fig. 1: CBD–IL-12 enhances the immunogenicity of immunologically cold tumours.

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Authors and Affiliations

  1. Institute of Biochemistry and Molecular Biology II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany

    Jürgen Scheller

  2. Institute of Molecular Medicine II, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany

    Philipp A. Lang

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  1. Jürgen Scheller
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  2. Philipp A. Lang
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Correspondence to Jürgen Scheller or Philipp A. Lang.

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Scheller, J., Lang, P.A. Collagen-binding IL-12 inflames ‘cold’ tumours. Nat Biomed Eng 4, 483–484 (2020). https://doi.org/10.1038/s41551-020-0560-7

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