Abstract
The RPLC retention of 1,n-halo(alkylthio)alkanes on an ODS phase with methanol/water (95%/5%) has been investigated. Replacement of a methyl group in a dialkyl sulphide R-S-R by a halogen atom X, to yield the title compounds X-(CH2)n-S-R, generally results in a retention decrease. This retention loss results either from the halogen atom proper, or from its immediate vicinity, or from a reduced retention contribution of the alkyl units. The methylene groups (n) between halogen and sulphur produce somewhat greater retention than the methylene groups in the alkyl groups R.
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Aced, G., Anklam, E. & Möckel, H.J. Retention behaviour of 1,n-halo(alkylthio)alkanes in HPLC. Chromatographia 25, 1067–1071 (1988). https://doi.org/10.1007/BF02259386
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DOI: https://doi.org/10.1007/BF02259386