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Etude de la consommation d'oxygène et de la teneur en acide désoxyribonucléique du foie à divers âges chez le rat

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Summary

The quantitative study of whole liver DNA and liver nuclei DNA at various ages, and the simultaneous study of oxygen uptake shows the following facts:

(1) The rate of oxygen consumption to the fresh weight or to the DNA or to diploid chromosomes group is the same for the adult or the young aged 8 days. The values of oxygen consumption calculated for one cell or for one nucleus (taking notice of the fact that the mean level of liver nuclei DNA varies with the age) at 8 days is only the half of the adult value. Even at two months the value is 20% lower than in the adult.

(2) In older animals there is a decrease of oxygen uptake which is more noticeable on a cellular scale than with the classical rate to fresh or dry weight. We affirm the fact that the diminution of the oxygen uptake of each cell is compensated by the increase of the number of cells.

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Authors and Affiliations

  1. Institut de chimie biologique, Faculté de médecine, Université de Strasbourg, France

    M. Jacob,  L. Mandel & P. Mandel

Authors
  1. M. Jacob
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  2. L. Mandel
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  3. P. Mandel
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Jacob, M., Mandel, L. & Mandel, P. Etude de la consommation d'oxygène et de la teneur en acide désoxyribonucléique du foie à divers âges chez le rat. Experientia 10, 218–220 (1954). https://doi.org/10.1007/BF02159281

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  • DOI: https://doi.org/10.1007/BF02159281

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