Skip to main content
SpringerLink
Log in

Activité gonadotrope d'un extrait d'urines de femmes en ménopause

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Summary

An extract from pooled postmenopausal urine has been investigated for its gonadotrophic activity. Dose-response curves have been constructed for its total gonadotrophic activity (stimulation of estrogen secretion as reflected by the uterine weight increase in immature mice) and for its ICSH activity (stimulation of androgen secretion as reflected by the ventral prostate weight increase in hypophysectomised immature rats). In hypophysectomised immature rats, the extract produced repair of the interstitial cells of the testes and complete spermatogenesis. It contains, therefore, FSH as well as ICSH activity in comparable amounts, a fact which opens up interesting therapeutic possibilities.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Nous employons dans ce travail les termes, critères et méthodes recommandés parF. Benz (Bâle),R. Borth (Genève),J. B. Brown (Edimbourg),W. R. Butt (Birmingham),A. C. Crooke (Birmingham),E. Diczfalusy (Stockholm),J. A. Loraine (Edimbourg),B. Lunenfeld (Genève),W. Schuler (Bâle) etH. de Watteville (Genève) lors d'une réunion à la Maternité de Genève, du 26 au 28 août 1953.

  2. H. M. Evans etM. E. Simpson,Physiology of the Gonadotrophins dansG. Pincus etK. V. Thimann,The Hormones, vol. 2 (Academic Press, New York 1950).

    Google Scholar 

  3. R. O. Greep etI. C. Jones, Recent Progr. Horm. Res.5, 242 (1950).

    Google Scholar 

  4. W. Schuler, Helv. physiol. pharmacol. Acta [C]5, 47 (1947).

    Google Scholar 

  5. Nous remercions vivement MM. le professeurJ. H. Gaddum et le DrJ. A. Loraine (Edimbourg) qui ont bien volu mettre à notre disposition un échantillon de cet extrait préparé par la MaisonOrganon (Newhouse, Ecosse).

  6. J. Dekanski, Brit. J. Exper. Path.30, 272 (1949).

    CAS  Google Scholar 

  7. J. A. Loraine, J. Endocrinol.6, 319 (1950).

    Article  CAS  Google Scholar 

  8. J. W. McArthur, Endocrinology50, 304 (1952).

    Article  CAS  Google Scholar 

  9. Nous employons dans ce travail les termes, critères et méthodes recommandés parF. Benz (Bâle),R. Borth (Genève),J. B. Brown (Edimbourg),W. R. Butt (Birmingham),A. C. Crooke (Birmingham),E. Diczfalusy (Stockholm),J. A. Loraine (Edimbourg),B. Lunenfeld (Genève),W. Schuler (Bâle) etH. de Watteville (Genève) lors d'une réunion à la Maternité de Genève, du 26 au 28 août 1953.

  10. J. H. Gaddum, Spec. Rep. Ser. M.R.C., Londres, N° 183 (1933).

  11. Cf. C. I. Bliss,Statistical Methods in Vitamin Research dans P. György,Vitamin Methods, vol. 2 (Acaemic Press, New York 1951).

    Google Scholar 

  12. E. C. Fieller, J. Roy. Statist. Soc., Suppl.7, 1 (1940).

    Google Scholar 

  13. Cf.D. J. Finney,Statistical Method in Biological Assay (Griffin, London 1952).

    Google Scholar 

  14. A. Linder,Statistiche Methoden (Birkhäuser, Basel 1951).

    Google Scholar 

  15. J. H. Gaddum, Spec. Ser. M.R.C., Londres, N° 183 (1933).

  16. Cf.C. I. Bliss,Statistical Methods in Vitamin Research dansP. György,Vitamin Methods, vol. 2 (Academic Press, New York 1951).

    Google Scholar 

  17. E. C. Fieller, J. Roy. Statist. Soc. Suppl.7, 1 (1940).

    Article  Google Scholar 

  18. Cf.D. J. Finney,Statistical Method in Biological Assay (Griffin, London 1952).

    Google Scholar 

  19. Nous employons dans ce travail les termes, critères et méthodes recommandés parF. Benz (Bâle),R. Borth (Genève),J. B. Brown (Edimbourg),W. R. Butt (Birmingham),A. C. Crooke (Birmingham),E. Diczfalusy (Stockholm),J. A. Loraine (Edimbourg),B. Lunenfeld (Genève),W. Schuler (Bâle) etH. de Watteville (Genève) lors d'une réunion à la Maternité de Genève, du 26 au 28 août 1953.

  20. Communication personnelle.

Download references

Author information

Authors and Affiliations

  1. Laboratoire d'Hormonologie de la Maternité, Genève

    R. Borth, B. Lunenfeld & H. de Watteville

Authors
  1. R. Borth
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. Lunenfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. H. de Watteville
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Borth, R., Lunenfeld, B. & de Watteville, H. Activité gonadotrope d'un extrait d'urines de femmes en ménopause. Experientia 10, 266–268 (1954). https://doi.org/10.1007/BF02157401

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02157401

Search

Navigation