Skip to main content
SpringerLink
Log in

Study of the relationship between the magnitude of biological activity and the structure of aliphatic compounds

  • Kurze Mitteilungen
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Es wurde festgestellt, dass die experimentellen Daten der sogenannten physikalischen Toxizität von aliphatischen Verbindungen die Gleichung log (τ i/τ Ät)=αβ erfüllen, woτ iundτ Ät die Grösse der biologischen Wirkung des i-ten Derivats und des Äthylderivats bezeichnen undα undβ die Konstanten sind. Die Bedeutung der beiden Konstanten wurde erwähnt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. C. Richet, C. R. Soc. Biol., Paris45, 775 (1893).

    Google Scholar 

  2. J. Traube, Arch. Physiol.105, 541 (1904).

    Article  Google Scholar 

  3. J. Traube, Arch. Physiol.132, 511 (1910).

    Article  Google Scholar 

  4. J. Traube, Arch. Physiol.153, 276 (1913).

    Article  CAS  Google Scholar 

  5. E. Overton,Studien über Theorie der Narkose (G. Fischer, Jena 1901).

    Google Scholar 

  6. J. Ferguson, Proc. R. Soc., Lond. [B]127, 387 (1939).

    CAS  Google Scholar 

  7. J. C. McGowan, J. appl. Chem.1, 120 (1951).

    Google Scholar 

  8. J. C. McGowan, J. appl. Chem.2, 323 (1952).

    Article  CAS  Google Scholar 

  9. J. C. McGowan, Arch. industr. Hyg. occup. Med., in press (in this paper the references to the previous papers of this author are given).

  10. N. V. Lazarev,Neelektrolity (Non-electrolyts) (Leningrad 1944).

  11. H. Fühner andE. Neubauer, Arch. exp. Path. Pharmak.56, 333 (1906).

    Article  Google Scholar 

  12. H. Meyer andH. Hemmi, Biochem. Z.277, 39 (1935).

    CAS  Google Scholar 

  13. M. Chvapil, R. Zahradník, andB. Čmuchalová, Biochim. biophys. Acta, in press.

  14. W. H. Read, Ann. appl. Biol.19, 432 (1932).

    Article  CAS  Google Scholar 

  15. F. Tilley andJ. Schaffer, J. Bacteriol.12, 303 (1926).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. H. M. Vernon, J. Physiol.47, 15 (1913–1914).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. L. P. Hammett,Physical Organic Chemistry (McGraw-Hill, New York 1940), p. 184.

    Google Scholar 

  18. R. W. Taft, Jr., J. Amer. chem. Soc.75, 4231 (1953).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Industrial Hygiene and Occupational Diseases, Prague, Czech Republic

    R. Zahradník & M. Chvapil

Authors
  1. R. Zahradník
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Chvapil
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Zahradník, R., Chvapil, M. Study of the relationship between the magnitude of biological activity and the structure of aliphatic compounds. Experientia 16, 511–512 (1960). https://doi.org/10.1007/BF02158373

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02158373

Keywords

Search

Navigation