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Antihypertensive activity of 7-azaindole-3-acetamidoxime and indole-1-acetamidoxime

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Zusammenfassung

7-Azaindol-3-acetamidoxim (I) und Indol-1-acetamidoxim (II) normalisieren hohen Blutdruck von Ratten und Hunden. Die blutdrucksenkende Wirkung von I scheint auf der Freisetzung von Brenzcatechinaminen und der Erschöpfung ihrer Depots zu beruhen. Die Wirkung von II findet zur Zeit keine befriedigende Erklärung.

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Literatur

  1. M. M. Robison andB. L. Robison, J. Am. chem. Soc.78, 1247 (1956).

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Authors and Affiliations

  1. Sterling-Winthrop Research Institute, Rensselaer, 12144, New York, N.Y., USA

    M. R. Bell, J. O. Hoppe, H. E. Lape, D. Wood, A. Arnold & W. H. Selberis

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  1. M. R. Bell
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  2. J. O. Hoppe
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  3. H. E. Lape
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  4. D. Wood
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  5. A. Arnold
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  6. W. H. Selberis
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Bell, M.R., Hoppe, J.O., Lape, H.E. et al. Antihypertensive activity of 7-azaindole-3-acetamidoxime and indole-1-acetamidoxime. Experientia 23, 298–299 (1967). https://doi.org/10.1007/BF02135698

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  • DOI: https://doi.org/10.1007/BF02135698

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