Summary
The oral administration of 0.4% taurine in drinking water for 14 consecutive days showed the following hepatic effects in male guinea pig. The percentage of tauro-conjugated biliary bile acids was increased from 17.2–54.2%; the ratio liver weight/body weight was increased, and fatty change was induced. Liver triglyceride concentration was accordingly increased; diglyceride and phosphatidylcholine concentrations were reduced by the treatment, while phosphatidylethanolamine level was not affected. These changes suggest an adverse effect of taurine administration on phosphatidylcholine hepatic synthesis.
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Cantafora, A., Mantovani, A., Masella, R. et al. Effect of taurine administration on liver lipids in guinea pig. Experientia 42, 407–408 (1986). https://doi.org/10.1007/BF02118631
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DOI: https://doi.org/10.1007/BF02118631