Skip to main content
SpringerLink
Log in

Development of adenocarcinomas after transplantation of rat glandular stomachs treated in vitro with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)

  • Short Communications
  • Oncology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Glandular stomachs of fetal and newborn Wistar rats were transplanted s.c. after treatment in vitro with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) at concentrations of 10, 5 and 1 μg/ml for 2 h. Eleven adenocarcinomas developed from 118 MNNG-treated transplants, whereas no adenocarcinomas developed from 28 untreated transplants. The incidence of adenocarcinomas in fetal glandular stomach (9/46) was significantly different (p<0.01) from that in glandular stomach of newborn rats (2/67). Various types of mesenchymal tumors also developed from untreated (9/28) and MNNG-treated (20/118) transplants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Sugimura, T., Fujimura, S., Kogure, K., Baba, T., Saito, T., Nagao, M., Hosoi, H., Shimosato, Y., and Yokoshima, T., Gann Monogr.13 (1972) 31.

    Google Scholar 

  2. Kurokawa, Y., Saito, S., and Sato, H., Gann Monogr.17 (1975) 87.

    CAS  Google Scholar 

  3. Kurokawa, Y., Saito, S., and Sato, H., S. Afr. Cancer Bull.24 (1980) 420.

    Google Scholar 

  4. Huh, N., Takaoka, T., and Katsuta, H. Jap. J. exp. Med.47 (1977) 413.

    CAS  PubMed  Google Scholar 

  5. Schryver-Kecskemet, K. De, Greider, M. H., Saks, M. K., Rieders, E. R., and McGuigan, J. E., Lab. Invest.37 (1977) 406.

    Google Scholar 

  6. Kurokawa, Y., Takahashi, M., Ohno, Y., Takamura, N., and Odashima, S., Tohoku J. exp. Med.134 (1981) 183.

    Article  CAS  PubMed  Google Scholar 

  7. Kurokawa, Y., Takahashi, M., Furihata, C., Ohno, Y., and Takamura, N., Gann72 (1981) 620.

    CAS  PubMed  Google Scholar 

  8. Smith, W. E., J. exp. Med.85 (1947) 459.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Toovey, E. W., Heller, L., and Webster, D. R., Cancer Res.11 (1951) 912.

    CAS  PubMed  Google Scholar 

  10. Tumyan, B. G., Svetlana, N. Z., George, J. S. M., and Bertha, I. L., J. natl Cancer Inst.52 (1974) 63.

    Article  CAS  PubMed  Google Scholar 

  11. Matsuyama, M., and Suzuki, H., Nagoya med. J.20 (1975) 63.

    Google Scholar 

  12. Sigaran, M. F., and Con-Wong, R., Gann70 (1979) 343.

    CAS  PubMed  Google Scholar 

  13. Sugimura, T., and Kawachi, T., Methods in Cancer Research, vol. 7, p. 245. Academic Press, New York, London 1973.

    Google Scholar 

  14. Yeomans, N. D., and Trier, J. S., Devl Biol.53 (1976) 206.

    Article  CAS  Google Scholar 

  15. Nomura, T., Cancer Res.34 (1974) 3363.

    CAS  PubMed  Google Scholar 

  16. Dao, T. L., and Sinha, D., J. natl Cancer Inst.49 (1972) 591.

    CAS  PubMed  Google Scholar 

  17. Rogers, S., J. natl Cancer Inst.15 (1955) 1675.

    CAS  PubMed  Google Scholar 

  18. Flaks, A., and Flaks, J. O., Br. J. Cancer22 (1968) 839.

    Article  PubMed Central  Google Scholar 

  19. Jull, J. W., Hawyluk, A., and Russel, A., J. natl Cancer Inst.40 (1968) 687.

    CAS  PubMed  Google Scholar 

  20. Roller, M. R., and Heidelberger, C., Int. J. Cancer2 (1967) 509.

    Article  CAS  PubMed  Google Scholar 

  21. Kreider, J. W., Bartlett, B. L., and Sharkey, F. E., Cancer Res.39 (1979) 273.

    CAS  PubMed  Google Scholar 

  22. Shimosato, T., Kodama, T., Tamai, S., and Kameya, T., Gann71 (1980) 402.

    CAS  PubMed  Google Scholar 

  23. Kurokawa, Y., unpublished data, 1981.

  24. Fukunishi, R., Mori, H., Kadota, A., and Yoshida, H., Trans. Jap. path. Soc.199 (1980) in Japanese.

Download references

Author information

Authors and Affiliations

  1. Division of Pathology, National Institute for Hygienic Sciences, 158, Tokyo, Japan

    Y. Kurokawa, M. Takahashi, Y. Hayashi, Y. Ohno & N. Takamura

Authors
  1. Y. Kurokawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Takahashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Hayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Y. Ohno
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Takamura
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kurokawa, Y., Takahashi, M., Hayashi, Y. et al. Development of adenocarcinomas after transplantation of rat glandular stomachs treated in vitro with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Experientia 39, 1404–1407 (1983). https://doi.org/10.1007/BF01990128

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01990128

Keywords

Search

Navigation