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Enkephalins induce asymmetrical effects on posture in the rat

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Summary

Enkephalins when applied subarachnoidally induce hind limb postural asymmetry in rats with transected spinal cord. The effect is antagonized by naloxone. Methionine-enkephalin induces predominantly left limb flexions while leucine-enkephalin causes mostly right limb flexions. The data suggest an asymmetry existing in the enkephalinergic system in the rat spinal cord.

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Authors and Affiliations

  1. USSR Research Centre of Cardiology, Academy of Medical Sciences, Petroverigsky Lane 10, 101837, Moscow, (USSR)

    E. I. Chazov, G. Ya. Bakalkin, K. N. Yarigin, E. D. Trushina, M. I. Titov & V. N. Smirnov

Authors
  1. E. I. Chazov
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  2. G. Ya. Bakalkin
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  3. K. N. Yarigin
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  4. E. D. Trushina
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  5. M. I. Titov
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  6. V. N. Smirnov
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Additional information

Acknowledgments. The authors are grateful to Prof. J. Baxter for critical review of the manuscript and stimulating discussion.

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Chazov, E.I., Bakalkin, G.Y., Yarigin, K.N. et al. Enkephalins induce asymmetrical effects on posture in the rat. Experientia 37, 887–889 (1981). https://doi.org/10.1007/BF01985696

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