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Lysosomal changes related to ageing and physical exercise in mouse cardiac and skeletal muscles

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Summary

Physical exercise increased the activities of arylsulphatase, cathepsin D and β-glucuronidase in mouse skeletal muscle but not in cardiac muscle. Exercise-induced lysosomal response was more prominent in young adult than in senescent mice. The lipofuscin content of cardiac and skeletal muscles increased markedly during ageing and was also found to increase slightly after exertion in young mice, but not in senescent ones.

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Authors and Affiliations

  1. Division of Muscle Research, Department of Cell Biology, University of Jyväskylä, SF-40100, Jyväskylä 10, Finland

    A. Salminen, H. Kainulainen & V. Vihko

Authors
  1. A. Salminen
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  2. H. Kainulainen
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  3. V. Vihko
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Additional information

This study was supported by the grants from the Ministry of Education and the Academy of Finland.

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Salminen, A., Kainulainen, H. & Vihko, V. Lysosomal changes related to ageing and physical exercise in mouse cardiac and skeletal muscles. Experientia 38, 781–782 (1982). https://doi.org/10.1007/BF01972267

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