Summary
Daily feeding of the common food color Orange II to mice in doses of up to 3.0 g/kg b.wt for 180 days had deleterious effects on somatic and spermatogonial chromosomes. The chromosomal abnormalities induced were breaks, gaps, constrictions, centric fusion, fragments of unknown origin, translocation, deletion, stickiness, ring chromosomes, pyknosis and other bizarre configurations.
References
Joint FAO/WHO Expert Committee on Food Additives 8th Tech. Rep. Ser. Wld Hlth Org./No. 309 (1965).
Fechheimer, N. S., Nature188 (1960) 247.
Dikshit, T. S. S., and Datta, K. K., Indian J. exp. Biol.16 (1978) 1000.
Plamer, K. A., Green, S., and Legator, M. S., Toxic. appl. Pharmac.22 (1972) 355.
Hirschhorn, K., and Cohen, M. M., Ann. N. Yo. Acad. Sci.151 (1968) 977.
Cohen, M. M., Can. J. Genet. Cytol.11 (1969) 1.
Mitra, A. B., and Manna, G. K., Indian J. med. Res.59 (1971) 1442.
Sharma, A., All India Congr. Cytol. Genet. (1981) 144.
Jain, N., Sahai, R., and Gupta, S. C., All India Congr. Cytol. Genet. (1981) 74.
Srivastava, N., Bhatnagar, V. S., and Prasad, O., Symp. Rec. Adv. exp. Zool. (1980) 42.
Majumdar, S. K., and Soloman, M., Can. J. Genet. Cytol.13 (1971) 189.
Banerjee, G., and Manna, G. K., Symp. Rec. Adv. exp. Zool. (1980) 46.
Singh, G. B., and Khanna, S. K., Indian J. exp. Biol.15 (1977) 1215.
Prasad, O., and Rastogi, P. B., Symp. Rec. Adv. exp. Zool. (1980) 62.
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Grateful acknowledgment is made to Prof. U.S. Srivastava, Zoology Department for providing necessary laboratory facilities.
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Prasad, O., Rastogi, P.B. Orange II induced cytogenetical changes in albino mice. Experientia 38, 1240–1242 (1982). https://doi.org/10.1007/BF01959764
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DOI: https://doi.org/10.1007/BF01959764