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Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes

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Summary

A dissociation between inhibition of RNA synthesis and cell lysis was observed when thymocytes of adrenalectomized rats were incubated with high concentrations of pregn-4-ene-11β-ol-3, 20-dione and pregna-1,4-diene-11β-ol-3,20-dione. In contrast, no dissociation of these effects was found with the typical glucocorticoids cortisol and corticosterone, nor with their 1,4-diene analogs under the same conditions.

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References

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Authors and Affiliations

  1. Laboratorio de Esteroides, Instituto de Biologia y Medicina Experimental, 1428 Buenos Aires, Argentina

    M. B. Castillo, M. D. Gonzalez, G. Burton, C. P. Lantos & A. Roldán

  2. Laboratorio de Esteroides, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428, Buenos Aires, Argentina

    M. B. Castillo, M. D. Gonzalez, G. Burton, C. P. Lantos & A. Roldán

  3. Departamento de Química Orgánica, Universidad de Buenos Aires, Pabellón 2-Ciudad Universitaria, 1428, Buenos Aires, Argentina

    M. B. Castillo, M. D. Gonzalez, G. Burton, C. P. Lantos & A. Roldán

Authors
  1. M. B. Castillo
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  2. M. D. Gonzalez
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  3. G. Burton
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  4. C. P. Lantos
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  5. A. Roldán
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Additional information

Acknowledgments. This work was supported by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina to the Instituto de Biologia y Medicina Experimental and the Programa de Regulación Hormonal y Metabólica as well as by financial help from the Secretaría de Ciencia y Tecnología.

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Castillo, M.B., Gonzalez, M.D., Burton, G. et al. Dissociation of glucocorticoid effects of C-21 steroids at high concentrations in thymocytes. Experientia 39, 617–618 (1983). https://doi.org/10.1007/BF01971126

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  • DOI: https://doi.org/10.1007/BF01971126

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