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Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat

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Acute or chronic injection of RX 77368 (a TRH analogue; 1 mg/kg s.c.) stimulated oxygen consumption (VO2) and brown adipose tissue activity in the rat, and decreased weight gain Other TRH analogues (CG 3509, RGH 2202) and TRH itself also stimulated VO2. These thermogenic actions are probably mediated centrally by stimulation of sympathetic outflow to brown fat.

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Authors and Affiliations

  1. Department of Physiological Sciences, University of Manchester Medical School, M13 9PT, Manchester, England

    E. C. Griffiths

  2. Department of Physiology, St. George's Hospital Medical School, Cranmer Terrace, SW17 0RE, London, England

    N. J. Rothwell & M. J. Stock

Authors
  1. E. C. Griffiths
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  2. N. J. Rothwell
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  3. M. J. Stock
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Griffiths, E.C., Rothwell, N.J. & Stock, M.J. Thermogenic effects of thyrotrophin-releasing hormone and its analogues in the rat. Experientia 44, 40–42 (1988). https://doi.org/10.1007/BF01960238

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