Summary
The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium.
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References
J. De Champlain, L.R. Krakoff and J. Axelrod, Circulation Res.20, 136 (1967).
S. Kazda, I. Pohlova, B. Bibr and J. Kockova, Am. J. Physiol.216, 1472 (1969).
L.R. Krakoff, J. De Champlain and J. Axelrod, Circulation Res.21, 583 (1967).
J. De Champlain, L.R. Krakoff and J. Axelrod, Circulation Res.23, 479 (1968).
J. De Champlain, R.A. Mueller and J. Axelrod, Circulation Res.25, 285 (1969).
K. Nakamura, M. Gerold and H. Thoenen, Naunyn-Schmiedeberg's Arch. Pharmak.268, 125 (1970).
A. Giachetti, R. Rubinstein and T.L. Clark, Eur. J. Pharmac.57, 99 (1979).
W.J. Louis, K.R. Krauss, I.J. Kopin and A. Sjoerdsma, Circulation Res.27, 589 (1970).
A.E. Doyle, Lancet2, 1399 (1968).
D. Ben-Ishay, R. Saliternik and A. Welner, Experientia28, 1321 (1972).
R. Keller, A. Oke, I. Mefford and R.N. Adams, Life Sci.19, 995 (1976).
D. Ben-Ishay, S. Dikstein and B. Shalita, Pflügers Arch.361, 153 (1976).
C. Bell and E.M. McLachlan, Clin. Sci.57, 203 (1979).
G. Feuerstein, N. Zamir, D. Ben-Ishay and Y. Gutman, J. Neurochem.33, 393 (1979).
J.H. Burn and M.J. Rand, J. Physiol. Lond.144, 314 (1958).
J. Le Lorier and F.E. Shideman, Proc. Soc. exp. Biol. Med.130, 265 (1969).
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Le Quan-Bui, K.H., Devynck, MA., Pernollet, MG. et al. Variations in cardiac noradrenaline content during sodium loading in hypertension prone and resistant rats. Experientia 37, 169–170 (1981). https://doi.org/10.1007/BF01963213
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DOI: https://doi.org/10.1007/BF01963213