Summary
In the present study we describe the occurrence of a metabolite of TCDD, which arose in several microbial cultures after long term incubation. The polar metabolite amounted approximately 1% of the input material, and was found to be a hydroxylated derivative of TCDD.
Similar content being viewed by others
Literature
H. Poiger and Ch. Schlatter, Nature281, 706 (1979).
J.C. Ramsey, J.G. Hefner, R.J. Karbowski, W.H. Braun and P.J. Gehring, Toxic. appl. Pharmac.48, A162 (1979).
Ph.C. Kearney, E.A. Woolson, A.R. Isensee and C.S. Helling, Environm. Health Perspect.5, 273 (1973).
A.L. Young, Ch.E. Thalken, E.L. Arnold, J.M. Cupello and L.G. Cockerham, Technical Report USAFA-TR-76.18, USAF Academy, Colorado 1976.
E. Homberger, G. Reggiani, J. Sambeth and H.K. Wipf, Ann. occup. Hyg.22, 327 (1979).
R.G. Nash and M.L. Beall, J. agric. Fd Chem.28, 614 (1980).
A.R. Isensee and G.E. Jones, Environm. Sci. Technol.9, 668 (1975).
C.T. Ward and F. Matsumura, Archs environm. Contam. Toxic.7, 349 (1978).
F. Matsumura and H.J. Benezet, Environm. Health Perspect.5, 253 (1973).
M. Philippi, V. Krasnobajew, J. Zeyer and R. Hütter, in: Proc. FEMS-Symposium ‘Biodegradation of Xenobiotics and Recalcitrant Compounds’, September 1980, Zürich, Eds Th. Leisinger, A. Cook, R. Hütter and J. Nüesch, Academic Press, New York/London 1981, p. 221.
R. Hütter and M. Philippi, in: Proc. Workshop ‘Chlorinated Dioxins and Related Compounds’ October 1980, Rome, p. 87. Eds O. Hutzinger, R.W. Frei, E. Merian and F. Pocchiari, Pergamon Press, Oxford/New York 1982.
J.R. Olson, T.A. Gasiewicz and R.A. Neal, Toxic. appl. Pharmac.56, 78 (1980).
H. Poiger, H.-R. Buser, H. Weber, U. Zweifel and Ch. Schlatter, Experientia38, 484 (1982).
H.-R. Buser and C. Rappe, Analyt. Chem.52, 2257 (1980).
K. Grob and K. Grob Jr, J. Chromat.151, 311 (1978).
K. Grob, J. high Resolut. Chromat. Chromat. Commun.1, 263 (1978).
K. Grob, G. Grob and K. Grob, Jr, J. high Resolut. Chromat. Chromat. Commun.2, 31, 677 (1979).
K. Grob and G. Grob, J. high Resolut. Chromat. Chromat. Commun.3, 197 (1980).
Author information
Authors and Affiliations
Additional information
The work was supported by a grant from the Swiss Federal Government to R.H. and M.P. We thank Dr K. Grob, GC-Laboratory ETH Zürich, Dübendorf, Switzerland, for providing the highly inert column used in this work, and H.-R. Buser, Swiss Federal Research Station, Wädenswil, Switzerland, for his help in the analysis of the14C-TCDD.
Rights and permissions
About this article
Cite this article
Philippi, M., Schmid, J., Wipf, H.K. et al. A microbial metabolite of TCDD. Experientia 38, 659–661 (1982). https://doi.org/10.1007/BF01964077
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01964077