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Paradoxical effect of 1-β-D-arabinofuranosyl cytosine triphosphate on bleomycin-induced unscheduled DNA synthesis in permeable sarcoma cells

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Summary

1-β-D-Arabinofuranosyl cytosine-5′-triphosphate (araCTP), an inhibitor of DNA synthesis, paradoxically enhanced unscheduled DNA synthesis (USD) induced by bleomycin in permeable mouse sarcoma cells. A greater enhancing effect of araCTP on bleomycin-induced USD was observed with lower concentrations of dCTP in the assay mixture. USD measured without bleomycin in nuclei isolated from mouse sarcoma cells was not enhanced, but inhibited by araCTP.

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Authors and Affiliations

  1. Department of Biochemistry, Cancer Institute, Okayama University Medical School, 2-5-1, Shikata-cho, 700, Okayama, Japan

    S. Seki, H. Iwamoto, Y. Maki & T. Oda

Authors
  1. S. Seki
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  2. H. Iwamoto
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  3. Y. Maki
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  4. T. Oda
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Additional information

Acknowledgments. The authors wish to thank Nippon Kayaku Co. (Tokyo, Japan) for providing copper-free bleomycin A2. This research was supported in part by a grant from the Japan Ministry of Education, Science and Culture.

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Seki, S., Iwamoto, H., Maki, Y. et al. Paradoxical effect of 1-β-D-arabinofuranosyl cytosine triphosphate on bleomycin-induced unscheduled DNA synthesis in permeable sarcoma cells. Experientia 38, 657–658 (1982). https://doi.org/10.1007/BF01964076

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  • DOI: https://doi.org/10.1007/BF01964076

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