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The effect of polyphloretin phosphate, polyoestradiol phosphate, a diphosphonate and a polyphosphate on calcification induced by dihydrotachysterol in skin, aorta and kidney of rats

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Zusammenfassung

Zwei Phosphatasehemmer (Polyphloretinphosphat und Polyoestradiolphosphat), ein Polyphosphat (Hexametaphosphat) und ein Diphosphonat (Ethan-1-hydroxy-1,1-diphosphonat) wurden auf ihre Fähigkeit untersucht, Verkalkungen zu verhindern, welche in der Haut, der Aorta und den Nieren von Ratten durch Dihydrotachysterol (DHT) hervorgerufen wurden. Das Diphosphonat erwies sich als der stärkste Hemmer; dann folgten das Polyphosphat und die zwei Phosphatasehemmer. Die Phosphatasehemmer wurden zusätzlich auf ihre Fähigkeit geprüft, die Calciumphosphat-Ausfällung in vitro zu verlangsamen. Polyphloretinphosphat besitzt diese Fähigkeit bei Konzentrationen von 10−5 M und mehr; Polyoestradiolphosphat ist unwirksam.

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Authors and Affiliations

  1. Department of Pathophysiology, University of Berne, Hügelweg 2, CH-3012, Berne, Switzerland

    P. A. Casey, G. Casey, H. Fleisch & R. G. G. Russel

  2. Laboratory for Experimental Surgery, Davos, Switzerland

    P. A. Casey, G. Casey, H. Fleisch & R. G. G. Russel

Authors
  1. P. A. Casey
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  2. G. Casey
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  3. H. Fleisch
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  4. R. G. G. Russel
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Additional information

Acknowledgments. This work has been supported by the Swiss National Fund, Grant No. 4564, the U.S. Public Health Service, Grant No. 07266, AB Leo, Hälsingborg, Sweden, and Procter and Gamble Company, Cincinnati, USA.

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Casey, P.A., Casey, G., Fleisch, H. et al. The effect of polyphloretin phosphate, polyoestradiol phosphate, a diphosphonate and a polyphosphate on calcification induced by dihydrotachysterol in skin, aorta and kidney of rats. Experientia 28, 137–138 (1972). https://doi.org/10.1007/BF01935714

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  • DOI: https://doi.org/10.1007/BF01935714

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