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Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture

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  • Endocrinologica
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Summary

Rabbit articular chondrocytes cultured in the presence of insulin-like growth factor I (IGF I) increased significantly the synthesis of both collagen and glycosaminoglycans. The increase in the ratio of35SO 2−4 to [3H]glucosamine observed in glycosaminoglycans synthesized in the presence of IGF I seems to indicate that IGF I affects sulphation and synthesis of these polyanionic macromolecules to a different extent.

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Authors and Affiliations

  1. Department of Pathophysiology, University of Berne, Murtenstrasse 35, CH-3010, Berne, Switzerland

    H. L. Guenther, Hannelore E. Guenther, E. R. Froesch & H. Fleisch

  2. Department of Medicine, Kantonsspital, CH-8006, Zurich, Switzerland

    H. L. Guenther, Hannelore E. Guenther, E. R. Froesch & H. Fleisch

Authors
  1. H. L. Guenther
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  2. Hannelore E. Guenther
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  3. E. R. Froesch
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  4. H. Fleisch
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Additional information

Acknowledgments. We thank Mrs Nelli Borel and Mrs Brunhilde Meier for preparing the manuscript. This work has been supported by the Swiss National Science Foundation (grants 3.824.79 and 3.380-0.78), and by the Ausbildungs- und Förderungsfonds der Arbeitsgemeinschaft für Osteosynthese (AO), Chur, Switzerland.

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Guenther, H.L., Guenther, H.E., Froesch, E.R. et al. Effect of insulin-like growth factor on collagen and glycosaminoglycan synthesis by rabbit articular chondrocytes in culture. Experientia 38, 979–981 (1982). https://doi.org/10.1007/BF01953688

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  • DOI: https://doi.org/10.1007/BF01953688

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