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Butterfly wing antineoplastic agents

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Zusammenfassung

Eine Voruntersuchung der Insektengruppe Lepidoptera auf anti-tumor-aktive Stoffe führte zu einer detaillierten chemischen Prüfung der aus Asien stammenden SchmetterlingeCatopsilia crocale Cramer (Pieridae) undPieris rapae cruavora. Ein bedeutender Teil der Anti-Tumor-Aktivität scheint ihren Ursprung in der chemischen Substanz Isoxanthopterin zu besitzen.

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References

  1. Important reviews of naturally occurring pteridines have been prepared byR. C. Elderfield andA. C. Metha inHeterocyclic Compounds (Ed.R. C. Elderfield; John Wiley and Sons, Inc., New York, N.Y. 1967), Vol. 9, p. 1–117 — andW. Pfleiderer, Angew. Chem. (Int. Ed. Engl.),3, 114 (1964).

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  4. The active constituents ofPrioneris thestylis are being examined in our laboratory and represent a new series of butterfly components.

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Authors and Affiliations

  1. Department of Chemistry, Arizona State University, 85281, Tempe, Arizona, USA

    G. R. Pettit, L. E. Houghton, N. H. Rogers, R. M. Coomes, D. F. Berger, P. R. Reucroft, J. F. Day, J. L. Hartwell & H. B. Wood Jr.

  2. Drug Research and Development, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    G. R. Pettit, L. E. Houghton, N. H. Rogers, R. M. Coomes, D. F. Berger, P. R. Reucroft, J. F. Day, J. L. Hartwell & H. B. Wood Jr.

Authors
  1. G. R. Pettit
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  2. L. E. Houghton
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  3. N. H. Rogers
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  4. R. M. Coomes
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  5. D. F. Berger
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  6. P. R. Reucroft
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  7. J. F. Day
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  8. J. L. Hartwell
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  9. H. B. Wood Jr.
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Additional information

The present contribution represents Part XXVII of the series Antineoplastic Agents. For Part XXVI refer toG. R. Pettit, J. F. Day, J. L. Hartwell andH. B. Wood, Nature, Lond.227, 962 (1970).

This investigation was supported by Public Health Service Research Grants No. CA-10612-01 to No. CA-10612-04 from the National Cancer Institute, and was presented in part at the American Chemical Society Meeting, Washington, D.C., September 1971. We are also grateful to the National Science Foundation for financial assistance (Grant numbers GB-4939 and GB-6979) used in obtaining the Atlas CH-4B and SM-1B mass spectrometers employed in this study.

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Pettit, G.R., Houghton, L.E., Rogers, N.H. et al. Butterfly wing antineoplastic agents. Experientia 28, 381–382 (1972). https://doi.org/10.1007/BF02008286

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