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The peroxisomal protein import machinery – a case report of transient ubiquitination with a new flavor

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Abstract.

The peroxisomal protein import machinery displays remarkable properties. Be it its capacity to accept already folded proteins as substrates, its complex architecture or its energetics, almost every aspect of this machinery seems unique. The list of unusual properties is still growing as shown by the recent finding that one of its central components, Pex5p, is transiently monoubiquitinated at a cysteine residue. However, the data gathered in recent years also suggest that the peroxisomal import machinery is not that exclusive and similarities with p97/Cdc48-mediated processes and with multisubunit RING-E3 ligases are starting to emerge. Here, we discuss these data trying to distill the principles by which this complex machinery operates.

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Authors and Affiliations

  1. Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto, Rua do Campo Alegre, 823, 4150–180, Porto, Portugal

    C. P. Grou, A. F. Carvalho, M. P. Pinto, I. S. Alencastre, T. A. Rodrigues, M. O. Freitas, T. Francisco, C. Sá-Miranda & J. E. Azevedo

  2. Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), Universidade do Porto, Largo Professor Abel Salazar, 2, 4009–003, Porto, Portugal

    C. P. Grou, A. F. Carvalho, M. P. Pinto, I. S. Alencastre, T. A. Rodrigues, M. O. Freitas & J. E. Azevedo

  3. Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, s/n, 4169–007, Porto, Portugal

    T. A. Rodrigues

Authors
  1. C. P. Grou
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  2. A. F. Carvalho
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  3. M. P. Pinto
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  4. I. S. Alencastre
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  5. T. A. Rodrigues
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  6. M. O. Freitas
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  7. T. Francisco
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  8. C. Sá-Miranda
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  9. J. E. Azevedo
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Corresponding author

Correspondence to J. E. Azevedo.

Additional information

Received 16 July 2008; received after revision 25 August 2008; accepted 29 August 2008

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Grou, C.P., Carvalho, A.F., Pinto, M.P. et al. The peroxisomal protein import machinery – a case report of transient ubiquitination with a new flavor. Cell. Mol. Life Sci. 66, 254–262 (2009). https://doi.org/10.1007/s00018-008-8415-5

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  • DOI: https://doi.org/10.1007/s00018-008-8415-5

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