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Comparative cytotoxicity of exogenous cadmium-metallothionein and cadmium ion in cultured vascular endothelial cells

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References

  • Blazka ME, Shaikh ZA (1991) Differences in cadmium and mercury uptakes by hepatocytes: Role of calcium channels. Toxicol Appl Pharmacol 110: 355–363

    Google Scholar 

  • Bruggeman IM, Temmink JHM, van Bladeren PJ (1992) Effect of glutathione and cysteine on apical and basolateral uptake and toxicity of CdCl2 in kidney cells (LLC-PK1). Toxic in Vitro 6: 195–200

    Google Scholar 

  • Cherian MG, Goyer RA, Valberg LS (1978) Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmiummetallothionein in mice. J Toxicol Environ Health 4: 861–868

    Google Scholar 

  • Dudley RE, Svoboda DJ, Klaassen CD (1982) Acute exposure to cadmium causes severe liver injury in rats. Toxicol Appl Pharmacol 65: 302–313

    Google Scholar 

  • Hoffman EO, Cook JA, DiLuzio NR, Coover JA (1975) The effects of acute cadmium administration in the liver and kidney of the rat. Lab Invest 32: 655–664

    Google Scholar 

  • Kaji T, Mishima A, Yamamoto C, Sakamoto M, Koizumi F (1992a) Effect of cadmium on the monolayer maintenance of vascular endothelial cells in culture. Toxicology 71: 267–276

    Google Scholar 

  • Kaji T, Mishima A, Koyanagi E, Yamamoto C, Sakamoto M, Kozuka H (1992b) Possible mechanism for zinc protection against cadmium cytotoxicity in cultured vascular endothelial cells. Toxicology 76: 257–270

    Google Scholar 

  • Kaji T, Yamamoto C, Tsubaki S, Ohkawara S, Sakamoto M, Sato M, Kozuka H (1993) Metallothionein induction by cadmium, cytokines, thrombin and endothelin-1 in cultured vascular endothelial cells. Life Sci 53: 1185–1191

    Google Scholar 

  • Kissane JM, Robins E (1958) The fluorometric measurement of deoxyribonucleic acid in animal tissue with special reference to the central nervous system. J Biol Chem 233: 184–188

    Google Scholar 

  • Maitani T, Suzuki KT (1982) Changes of essential metal levels in selected tissues and splenomegaly induced by the injection of suspending cadmium salt into mice. Toxicol Appl Pharmacol 62: 219–227

    Google Scholar 

  • Maitani T, Waalkes MP, Klaassen CD (1984) Distribution of cadmium after oral administration of cadmium-thionein to mice. Toxicol Appl Pharmacol 74: 237–243

    Google Scholar 

  • Maitani T, Watahiki A, Suzuki KT (1986) Acute renal dysfunction by cadmium injected with cysteine in relation to renal critical concentration of cadmium. Arch Toxicol 58: 136–140

    Google Scholar 

  • Nolan CV, Shaikh ZA (1986) The vascular endothelium as a target tissue in acute cadmium toxicity. Life Sci 39: 1403–1409

    Google Scholar 

  • Onosaka S, Tanaka K, Doi M, Okahara K (1981) A simplified procedure for determination of metallothionein in animal tissue. Eisei Kagaku 24: 128–131

    Google Scholar 

  • Suzuki KT, Maitani T, Takenaka S (1979) Fate of intraperitoneally injected liver metallothionein in rat kidney. Chem Pharm Bull 27: 647–653

    Google Scholar 

  • Webb M, Etienne AT (1977) Studies on the toxicity and metabolism of cadmium-thionein. Biochem Pharmacol 26: 25–30

    Google Scholar 

  • Yamamoto C, Kaji T, Sakamoto M, Kozuka H (1993) Cadmium stimulation of plasminogen activator inhibitor-1 release from human vascular endothelial cells in culture. Toxicology 83: 215–223

    Google Scholar 

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Kaji, T., Mishima, A., Machida, M. et al. Comparative cytotoxicity of exogenous cadmium-metallothionein and cadmium ion in cultured vascular endothelial cells. Bull. Environ. Contam. Toxicol. 54, 501–506 (1995). https://doi.org/10.1007/BF00192591

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  • DOI: https://doi.org/10.1007/BF00192591

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