NK cells become cytotoxic upon receiving a signal through their activation receptors. The orphan proteins H-60 and Rae1 have now been identified as ligands for the mouse NKG2D activation receptor. Remarkably they are inducible and may be blocked by a viral protein.
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Yokoyama, W. Now you see it, now you don't!. Nat Immunol 1, 95–97 (2000). https://doi.org/10.1038/77878
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DOI: https://doi.org/10.1038/77878
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