Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppress abnormal tau phosphorylation, known to be involved in the formation of neurofibrillary tangles in the brain.
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Fischer, P. Turning down tau phosphorylation. Nat Chem Biol 4, 448–449 (2008). https://doi.org/10.1038/nchembio0808-448
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DOI: https://doi.org/10.1038/nchembio0808-448
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